메뉴 건너뛰기




Volumn 176, Issue 12, 2012, Pages 1101-1109

Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study

Author keywords

case parent triads; diabetes; genetics; neural tube defects; obesity

Indexed keywords

DIABETES; GENETIC VARIATION; GENOTYPE; HEALTH RISK; HOMEOSTASIS; OBESITY; POLYMORPHISM; PUBLIC HEALTH; RISK FACTOR;

EID: 84871209371     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kws190     Document Type: Article
Times cited : (39)

References (67)
  • 1
    • 0022919056 scopus 로고
    • Neural tube defects: A review of human and animal studies on the etiology of neural tube defects
    • Campbell LR, Dayton DH, Sohal GS. Neural tube defects: a review of human and animal studies on the etiology of neural tube defects. Teratology. 1986;34(2): 171-187.
    • (1986) Teratology , vol.34 , Issue.2 , pp. 171-187
    • Campbell, L.R.1    Dayton, D.H.2    Sohal, G.S.3
  • 2
    • 34447527886 scopus 로고    scopus 로고
    • Health care expenditures of children and adults with spina bifida in a privately insured U.S. population
    • Ouyang L, Grosse SD, Armour BS, et al. Health care expenditures of children and adults with spina bifida in a privately insured U.S. population. Birth Defects Res A Clin Mol Teratol. 2007;79(7):552-558.
    • (2007) Birth Defects Res A Clin Mol Teratol , vol.79 , Issue.7 , pp. 552-558
    • Ouyang, L.1    Grosse, S.D.2    Armour, B.S.3
  • 3
    • 0034021816 scopus 로고    scopus 로고
    • Spina bifida phenotypes in infants or fetuses of obese mothers
    • Shaw GM, Todoroff K, Finnell RH, et al. Spina bifida phenotypes in infants or fetuses of obese mothers. Teratology. 2000;61(5):376-381.
    • (2000) Teratology , vol.61 , Issue.5 , pp. 376-381
    • Shaw, G.M.1    Todoroff, K.2    Finnell, R.H.3
  • 4
    • 0029869817 scopus 로고    scopus 로고
    • Risk of neural tube defectaffected pregnancies among obese women
    • Shaw GM, Velie EM, Schaffer D. Risk of neural tube defectaffected pregnancies among obese women. JAMA. 1996; 275(14):1093-1096.
    • (1996) JAMA , vol.275 , Issue.14 , pp. 1093-1096
    • Shaw, G.M.1    Velie, E.M.2    Schaffer, D.3
  • 5
    • 0037964438 scopus 로고    scopus 로고
    • Maternal obesity and risk for birth defects
    • Watkins ML, Rasmussen SA, Honein MA, et al. Maternal obesity and risk for birth defects. Pediatrics. 2003; 111(5):1152-1158.
    • (2003) Pediatrics , vol.111 , Issue.5 , pp. 1152-1158
    • Watkins, M.L.1    Rasmussen, S.A.2    Honein, M.A.3
  • 6
    • 0029799199 scopus 로고    scopus 로고
    • Is maternal obesity a risk factor for anencephaly and spina bifida?
    • Watkins ML, Scanlon KS, Mulinare J, et al. Is maternal obesity a risk factor for anencephaly and spina bifida? Epidemiology. 1996;7(5):507-512.
    • (1996) Epidemiology , vol.7 , Issue.5 , pp. 507-512
    • Watkins, M.L.1    Scanlon, K.S.2    Mulinare, J.3
  • 7
    • 0017251712 scopus 로고
    • Congenital malformations in infants of diabetic mothers
    • Soler NG, Walsh CH, Malins JM. Congenital malformations in infants of diabetic mothers. Q J Med. 1976;45(178): 303-313.
    • (1976) Q J Med , vol.45 , Issue.178 , pp. 303-313
    • Soler, N.G.1    Walsh, C.H.2    Malins, J.M.3
  • 8
    • 34547814677 scopus 로고    scopus 로고
    • Prepregnancy obesity as a risk factor for structural birth defects. National birth defects prevention Study
    • Waller DK, Shaw GM, Rasmussen SA, et al. Prepregnancy obesity as a risk factor for structural birth defects. National Birth Defects Prevention Study. Arch Pediatr Adolesc Med. 2007;161(8):745-750.
    • (2007) Arch Pediatr Adolesc Med , vol.161 , Issue.8 , pp. 745-750
    • Waller, D.K.1    Shaw, G.M.2    Rasmussen, S.A.3
  • 9
    • 0028226855 scopus 로고
    • Are obese women at higher risk for producing malformed offspring?
    • Waller DK, Mills JL, Simpson JL, et al. Are obese women at higher risk for producing malformed offspring? Am J Obstet Gynecol. 1994;170(2):541-548.
    • (1994) Am J Obstet Gynecol , vol.170 , Issue.2 , pp. 541-548
    • Waller, D.K.1    Mills, J.L.2    Simpson, J.L.3
  • 10
    • 0035214757 scopus 로고    scopus 로고
    • Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans
    • Hendricks KA, Nuno OM, Suarez L, et al. Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans. Epidemiology. 2001;12(6):630-635.
    • (2001) Epidemiology , vol.12 , Issue.6 , pp. 630-635
    • Hendricks, K.A.1    Nuno, O.M.2    Suarez, L.3
  • 11
    • 0029869816 scopus 로고    scopus 로고
    • Prepregnant weight in relation to risk of neural tube defects
    • Werler MM, Louik C, Shapiro S, et al. Prepregnant weight in relation to risk of neural tube defects. JAMA. 1996;275(14): 1089-1092.
    • (1996) JAMA , vol.275 , Issue.14 , pp. 1089-1092
    • Werler, M.M.1    Louik, C.2    Shapiro, S.3
  • 12
    • 2642626652 scopus 로고    scopus 로고
    • Maternal smoking, body mass index, and neural tube defects
    • Källén K. Maternal smoking, body mass index, and neural tube defects. Am J Epidemiol. 1998;147(12):1103-1111.
    • (1998) Am J Epidemiol , vol.147 , Issue.12 , pp. 1103-1111
    • Källén, K.1
  • 16
    • 33750133607 scopus 로고    scopus 로고
    • Maternal obesity, metabolism, and pregnancy outcomes
    • King JC. Maternal obesity, metabolism, and pregnancy outcomes. Annu Rev Nutr. 2006;26:271-291.
    • (2006) Annu Rev Nutr , vol.26 , pp. 271-291
    • King, J.C.1
  • 17
    • 35448991692 scopus 로고    scopus 로고
    • Metabolic syndrome features and risk of neural tube defects
    • doi:10.1186/1471-2393-7-21
    • Ray JG, Thompson MD, Vermeulen MJ, et al. Metabolic syndrome features and risk of neural tube defects. BMC Pregnancy Childbirth. 2007;7:21. (doi:10.1186/1471-2393-7-21).
    • (2007) BMC Pregnancy Childbirth , vol.7 , pp. 21
    • Ray, J.G.1    Thompson, M.D.2    Vermeulen, M.J.3
  • 18
    • 33644856172 scopus 로고    scopus 로고
    • Teratology Public Affairs Committee position paper: Maternal obesity and pregnancy
    • Scialli AR. Teratology Public Affairs Committee position paper: maternal obesity and pregnancy. Birth Defects Res A Clin Mol Teratol. 2006;76(2):73-77.
    • (2006) Birth Defects Res A Clin Mol Teratol , vol.76 , Issue.2 , pp. 73-77
    • Scialli, A.R.1
  • 19
    • 0027241208 scopus 로고
    • Abnormal metabolism and the risk for birth defects with emphasis on diabetes
    • Jovanovic-Peterson L, Peterson CM. Abnormal metabolism and the risk for birth defects with emphasis on diabetes. Ann N Y Acad Sci. 1993;678:228-243.
    • (1993) Ann N y Acad Sci , vol.678 , pp. 228-243
    • Jovanovic-Peterson, L.1    Peterson, C.M.2
  • 20
    • 0028125791 scopus 로고
    • Cellular-tissue localization and regulation of the GLUT-1 protein in both the embryo and the visceral yolk sac from normal and experimental diabetic rats during the early postimplantation period
    • Trocino RA, Akazawa S, Takino H, et al. Cellular-tissue localization and regulation of the GLUT-1 protein in both the embryo and the visceral yolk sac from normal and experimental diabetic rats during the early postimplantation period. Endocrinology. 1994;134(2):869-878.
    • (1994) Endocrinology , vol.134 , Issue.2 , pp. 869-878
    • Trocino, R.A.1    Akazawa, S.2    Takino, H.3
  • 21
    • 0027366222 scopus 로고
    • Glucose transporter gene expression in rat conceptus during early organogenesis and exposure to insulin-induced hypoglycemic serum
    • Maeda Y, Akazawa S, Akazawa M, et al. Glucose transporter gene expression in rat conceptus during early organogenesis and exposure to insulin-induced hypoglycemic serum. Acta Diabetol. 1993;30(2):73-78.
    • (1993) Acta Diabetol , vol.30 , Issue.2 , pp. 73-78
    • Maeda, Y.1    Akazawa, S.2    Akazawa, M.3
  • 22
    • 0027237114 scopus 로고
    • Glucose transporter gene expression in rat conceptus during high glucose culture
    • Takao Y, Akazawa S, Matsumoto K, et al. Glucose transporter gene expression in rat conceptus during high glucose culture. Diabetologia. 1993;36(8):696-706.
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 696-706
    • Takao, Y.1    Akazawa, S.2    Matsumoto, K.3
  • 23
    • 33845939675 scopus 로고    scopus 로고
    • TCF7L2: The biggest story in diabetes genetics since HLA?
    • Zeggini E, McCarthy MI. TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia. 2007;50(1):1-4.
    • (2007) Diabetologia , vol.50 , Issue.1 , pp. 1-4
    • Zeggini, E.1    McCarthy, M.I.2
  • 24
    • 79952474482 scopus 로고    scopus 로고
    • From GWAS to biology: Lessons from FTO
    • Tung YC, Yeo GS. From GWAS to biology: lessons from FTO. Ann N Y Acad Sci. 2011;1220(1):162-171.
    • (2011) Ann N y Acad Sci , vol.1220 , Issue.1 , pp. 162-171
    • Tung, Y.C.1    Yeo, G.S.2
  • 25
    • 78650657378 scopus 로고    scopus 로고
    • Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population
    • Carter TC, Pangilinan F, Troendle JF, et al. Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. Am J Med Genet A. 2011;155A(1):14-21.
    • (2011) Am J Med Genet A , vol.155 A , Issue.1 , pp. 14-21
    • Carter, T.C.1    Pangilinan, F.2    Troendle, J.F.3
  • 26
    • 38949096877 scopus 로고    scopus 로고
    • Genes in glucose metabolism and association with spina bifida
    • Davidson CM, Northrup H, King TM, et al. Genes in glucose metabolism and association with spina bifida. Reprod Sci. 2008;15(1):51-58.
    • (2008) Reprod Sci , vol.15 , Issue.1 , pp. 51-58
    • Davidson, C.M.1    Northrup, H.2    King, T.M.3
  • 27
    • 0034845303 scopus 로고    scopus 로고
    • The national birth defects prevention study
    • Yoon PW, Rasmussen SA, Lynberg MC, et al. The National Birth Defects Prevention Study. Public Health Rep. 2001; 116(suppl 1):32-40.
    • (2001) Public Health Rep , vol.116 , Issue.SUPPL. 1 , pp. 32-40
    • Yoon, P.W.1    Rasmussen, S.A.2    Lynberg, M.C.3
  • 28
    • 0141925970 scopus 로고    scopus 로고
    • Guidelines for case classification for the National Birth Defects Prevention Study
    • Rasmussen SA, Olney RS, Holmes LB, et al. Guidelines for case classification for the National Birth Defects Prevention Study. Birth Defects Res A Clin Mol Teratol. 2003;67(3): 193-201.
    • (2003) Birth Defects Res A Clin Mol Teratol , vol.67 , Issue.3 , pp. 193-201
    • Rasmussen, S.A.1    Olney, R.S.2    Holmes, L.B.3
  • 29
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007;316(5829):1341-1345.
    • (2007) Science , vol.316 , Issue.5829 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 30
    • 0141995058 scopus 로고    scopus 로고
    • Risk factors for neural tube defects: Associations between uncoupling protein 2 polymorphisms and spina bifida
    • Volcik KA, Shaw GM, Zhu H, et al. Risk factors for neural tube defects: associations between uncoupling protein 2 polymorphisms and spina bifida. Birth Defects Res A Clin Mol Teratol. 2003;67(3):158-161.
    • (2003) Birth Defects Res A Clin Mol Teratol , vol.67 , Issue.3 , pp. 158-161
    • Volcik, K.A.1    Shaw, G.M.2    Zhu, H.3
  • 31
    • 0032857338 scopus 로고    scopus 로고
    • A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
    • Pizzuti A, Frittitta L, Argiolas A, et al. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes. 1999;48(9):1881-1884.
    • (1999) Diabetes , vol.48 , Issue.9 , pp. 1881-1884
    • Pizzuti, A.1    Frittitta, L.2    Argiolas, A.3
  • 32
    • 0034664846 scopus 로고    scopus 로고
    • Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats
    • Ohnuma H, Yamatani K, Daimon M, et al. Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats. Physiol Behav. 2000; 70(5):527-532.
    • (2000) Physiol Behav , vol.70 , Issue.5 , pp. 527-532
    • Ohnuma, H.1    Yamatani, K.2    Daimon, M.3
  • 33
    • 0029857775 scopus 로고    scopus 로고
    • UKPDS 19: Heterogeneity in NIDDM: Separate contributions of IRS-1 and beta 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study
    • Zhang Y, Wat N, Stratton IM, et al. UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and beta 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study. Diabetologia. 1996;39(12):1505-1511.
    • (1996) Diabetologia , vol.39 , Issue.12 , pp. 1505-1511
    • Zhang, Y.1    Wat, N.2    Stratton, I.M.3
  • 34
    • 33845770418 scopus 로고    scopus 로고
    • Analysis of PGC-1α variants Gly482Ser and Thr612Met concerning their PPARγ2-coactivation function
    • Nitz I, Ewert A, Klapper M, et al. Analysis of PGC-1α variants Gly482Ser and Thr612Met concerning their PPARγ2-coactivation function. Biochem Biophys Res Commun. 2007;353(2):481-486.
    • (2007) Biochem Biophys Res Commun , vol.353 , Issue.2 , pp. 481-486
    • Nitz, I.1    Ewert, A.2    Klapper, M.3
  • 35
    • 33846822914 scopus 로고    scopus 로고
    • Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy
    • Li R, Thorens B, Loeken MR. Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy. Diabetologia. 2007;50(3):682-689.
    • (2007) Diabetologia , vol.50 , Issue.3 , pp. 682-689
    • Li, R.1    Thorens, B.2    Loeken, M.R.3
  • 36
    • 0036391372 scopus 로고    scopus 로고
    • Integration of DNA sample collection into a multi-site birth defects casecontrol study. National Birth Defects Prevention Study
    • Rasmussen SA, Lammer EJ, Shaw GM, et al. Integration of DNA sample collection into a multi-site birth defects casecontrol study. National Birth Defects Prevention Study. Teratology. 2002;66(4):177-184.
    • (2002) Teratology , vol.66 , Issue.4 , pp. 177-184
    • Rasmussen, S.A.1    Lammer, E.J.2    Shaw, G.M.3
  • 37
    • 0031949066 scopus 로고    scopus 로고
    • A log-linear approach to case-parent-triad data: Assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting
    • Weinberg CR, Wilcox AJ, Lie RT. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet. 1998; 62(4):969-978.
    • (1998) Am J Hum Genet , vol.62 , Issue.4 , pp. 969-978
    • Weinberg, C.R.1    Wilcox, A.J.2    Lie, R.T.3
  • 38
    • 3042656755 scopus 로고    scopus 로고
    • Method for using complete and incomplete trios to identify genes related to a quantitative trait
    • Kistner EO, Weinberg CR. Method for using complete and incomplete trios to identify genes related to a quantitative trait. Genet Epidemiol. 2004;27(1):33-42.
    • (2004) Genet Epidemiol , vol.27 , Issue.1 , pp. 33-42
    • Kistner, E.O.1    Weinberg, C.R.2
  • 40
    • 0033362166 scopus 로고    scopus 로고
    • Allowing for missing parents in genetic studies of case-parent triads
    • Weinberg CR. Allowing for missing parents in genetic studies of case-parent triads. Am J Hum Genet. 1999; 64(4):1186-1193.
    • (1999) Am J Hum Genet , vol.64 , Issue.4 , pp. 1186-1193
    • Weinberg, C.R.1
  • 41
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57(1):289-300.
    • (1995) J R Stat Soc B , vol.57 , Issue.1 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 42
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet. 2007;39(6):724-726.
    • (2007) Nat Genet , vol.39 , Issue.6 , pp. 724-726
    • Dina, C.1    Meyre, D.2    Gallina, S.3
  • 43
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    • doi:10.1371/journal.pgen.0030115
    • Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007; 3(7):e115. (doi:10.1371/journal.pgen.0030115).
    • (2007) PLoS Genet , vol.3 , Issue.7
    • Scuteri, A.1    Sanna, S.2    Chen, W.M.3
  • 44
    • 79958076981 scopus 로고    scopus 로고
    • FTO gene polymorphisms and obesity risk: A meta-analysis
    • doi:10.1186/1741-7015-9-71
    • Peng S, Zhu Y, Xu F, et al. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med. 2011;9:71. (doi:10.1186/1741-7015-9-71).
    • (2011) BMC Med , vol.9 , pp. 71
    • Peng, S.1    Zhu, Y.2    Xu, F.3
  • 45
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889-894.
    • (2007) Science , vol.316 , Issue.5826 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3
  • 46
    • 80052760346 scopus 로고    scopus 로고
    • Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort
    • Wing MR, Ziegler JM, Langefeld CD, et al. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. Int J Obes (Lond). 2011;35(9):1173- 1182.
    • (2011) Int J Obes (Lond) , vol.35 , Issue.9 , pp. 1173-1182
    • Wing, M.R.1    Ziegler, J.M.2    Langefeld, C.D.3
  • 47
    • 79955776932 scopus 로고    scopus 로고
    • FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans
    • Nock NL, Plummer SJ, Thompson CL, et al. FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans. Carcinogenesis. 2011;32(5):748-756.
    • (2011) Carcinogenesis , vol.32 , Issue.5 , pp. 748-756
    • Nock, N.L.1    Plummer, S.J.2    Thompson, C.L.3
  • 48
    • 80155195962 scopus 로고    scopus 로고
    • Common variants of FTO and the risk of obesity and type 2 diabetes in Indians
    • Chauhan G, Tabassum R, Mahajan A, et al. Common variants of FTO and the risk of obesity and type 2 diabetes in Indians. J Hum Genet. 2011;56(10):720-726.
    • (2011) J Hum Genet , vol.56 , Issue.10 , pp. 720-726
    • Chauhan, G.1    Tabassum, R.2    Mahajan, A.3
  • 49
    • 77955981202 scopus 로고    scopus 로고
    • The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels
    • Berulava T, Horsthemke B. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur J Hum Genet. 2010;18(9):1054- 1056.
    • (2010) Eur J Hum Genet , vol.18 , Issue.9 , pp. 1054-1056
    • Berulava, T.1    Horsthemke, B.2
  • 50
    • 34249819669 scopus 로고    scopus 로고
    • From fused toes in mice to human obesity
    • Groop L. From fused toes in mice to human obesity. Nat Genet. 2007;39(6):706-707.
    • (2007) Nat Genet , vol.39 , Issue.6 , pp. 706-707
    • Groop, L.1
  • 51
    • 77953292057 scopus 로고    scopus 로고
    • The genetics of obesity: FTO leads the way
    • Fawcett KA, Barroso I. The genetics of obesity: FTO leads the way. Trends Genet. 2010;26(6):266-274.
    • (2010) Trends Genet , vol.26 , Issue.6 , pp. 266-274
    • Fawcett, K.A.1    Barroso, I.2
  • 52
    • 77449126999 scopus 로고    scopus 로고
    • Prevalence of loss-of-function FTO mutations in lean and obese individuals
    • Meyre D, Proulx K, Kawagoe-Takaki H, et al. Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes. 2010;59(1):311-318.
    • (2010) Diabetes , vol.59 , Issue.1 , pp. 311-318
    • Meyre, D.1    Proulx, K.2    Kawagoe-Takaki, H.3
  • 53
    • 12444260644 scopus 로고    scopus 로고
    • Body mass index and serum folate in childbearing age women
    • Mojtabai R. Body mass index and serum folate in childbearing age women. Eur J Epidemiol. 2004;19(11):1029-1036.
    • (2004) Eur J Epidemiol , vol.19 , Issue.11 , pp. 1029-1036
    • Mojtabai, R.1
  • 54
    • 77958468040 scopus 로고    scopus 로고
    • Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes
    • Hansson O, Zhou Y, Renström E, et al. Molecular function of TCF7L2: consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes. Curr Diab Rep. 2010;10(6):444-451.
    • (2010) Curr Diab Rep , vol.10 , Issue.6 , pp. 444-451
    • Hansson, O.1    Zhou, Y.2    Renström, E.3
  • 55
    • 40949141938 scopus 로고    scopus 로고
    • Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
    • Shu L, Sauter NS, Schulthess FT, et al. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes. 2008;57(3):645-653.
    • (2008) Diabetes , vol.57 , Issue.3 , pp. 645-653
    • Shu, L.1    Sauter, N.S.2    Schulthess, F.T.3
  • 56
    • 67249096093 scopus 로고    scopus 로고
    • Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired beta-cell function
    • Shu L, Matveyenko AV, Kerr-Conte J, et al. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet. 2009; 18(13):2388-2399.
    • (2009) Hum Mol Genet , vol.18 , Issue.13 , pp. 2388-2399
    • Shu, L.1    Matveyenko, A.V.2    Kerr-Conte, J.3
  • 57
    • 64649105053 scopus 로고    scopus 로고
    • TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
    • da Silva Xavier G, Loder MK, McDonald A, et al. TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes. 2009;58(4):894-905.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 894-905
    • Da Silva Xavier, G.1    Loder, M.K.2    McDonald, A.3
  • 58
    • 33847014094 scopus 로고    scopus 로고
    • Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans
    • Lehman DM, Hunt KJ, Leach RJ, et al. Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes. 2007; 56(2):389-393.
    • (2007) Diabetes , vol.56 , Issue.2 , pp. 389-393
    • Lehman, D.M.1    Hunt, K.J.2    Leach, R.J.3
  • 59
    • 79957896666 scopus 로고    scopus 로고
    • Sixteen years and counting: An update on leptin in energy balance
    • Gautron L, Elmquist JK. Sixteen years and counting: an update on leptin in energy balance. J Clin Invest. 2011; 121(6):2087-2093.
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2087-2093
    • Gautron, L.1    Elmquist, J.K.2
  • 60
    • 0034062130 scopus 로고    scopus 로고
    • Microsatellites proximal to leptin and leptin receptor as risk factors for spina bifida
    • Shaw GM, Barber R, Todoroff K, et al. Microsatellites proximal to leptin and leptin receptor as risk factors for spina bifida. Teratology. 2000;61(3):231-235.
    • (2000) Teratology , vol.61 , Issue.3 , pp. 231-235
    • Shaw, G.M.1    Barber, R.2    Todoroff, K.3
  • 61
    • 33947327738 scopus 로고    scopus 로고
    • ESCI Award 2006 Mitochondrial function and endocrine diseases
    • Stark R, Roden M. ESCI Award 2006. Mitochondrial function and endocrine diseases. Eur J Clin Invest. 2007; 37(4):236-248.
    • (2007) Eur J Clin Invest , vol.37 , Issue.4 , pp. 236-248
    • Stark, R.1    Roden, M.2
  • 62
    • 84455207168 scopus 로고    scopus 로고
    • Genetic variance in uncoupling protein 2 in relation to obesity, type 2 diabetes, and related metabolic traits: Focus on the functional-866G>A promoter variant (rs659366)
    • doi:10.1155/2011/340241
    • Dalgaard LT. Genetic variance in uncoupling protein 2 in relation to obesity, type 2 diabetes, and related metabolic traits: focus on the functional-866G>A promoter variant (rs659366). J Obes. 2011;2011:340241. (doi:10.1155/2011/340241).
    • (2011) J Obes 2011 , pp. 340241
    • Dalgaard, L.T.1
  • 63
    • 84855480203 scopus 로고    scopus 로고
    • Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population
    • Martinez-Hervas S, Mansego ML, de Marco G, et al. Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population. Eur J Clin Invest. 2012;42(2):171-178.
    • (2012) Eur J Clin Invest , vol.42 , Issue.2 , pp. 171-178
    • Martinez-Hervas, S.1    Mansego, M.L.2    De Marco, G.3
  • 64
    • 65449154046 scopus 로고    scopus 로고
    • Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese
    • Kosuge K, Soma M, Nakayama T, et al. Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese. Endocrine. 2008;34(1-3):87-95.
    • (2008) Endocrine , vol.34 , Issue.1-3 , pp. 87-95
    • Kosuge, K.1    Soma, M.2    Nakayama, T.3
  • 66
    • 0002629270 scopus 로고
    • Maximum likelihood from incomplete data via the em algorithm
    • Dempster AP Laird NM, Rubin DB. Maximum likelihood from incomplete data via the EM algorithm. J R Stat Soc Ser B. 1977;39(1):1-28.
    • (1977) J R Stat Soc ser B , vol.39 , Issue.1 , pp. 1-28
    • Dempster, A.P.1    Laird, N.M.2    Rubin, D.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.