Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate

Molecular Biology of the Cell

Volumn 23, Issue 24, 2012, Pages 4668-4678

  Tyler, Ryan E ^a   Pearce, Margaret M P ^a   Shaler, Thomas A ^b   Olzmann, James A ^a   Greenblatt, Ethan J ^a   Kopito, Ron R ^a  

^a STANFORD UNIVERSITY   (United States)

^b SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD147 ANTIGEN; HRD1 PROTEIN; KIFUNENSINE; LECTIN; LIGASE; OS 9 PROTEIN; PROTEASOME; SEL1L PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME SUBSTRATE COMPLEX; MASS SPECTROMETRY; MUTATION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION;

ALKALOIDS; ANTIGENS, CD147; BINDING SITES; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; ENZYME INHIBITORS; GLYCOSYLATION; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; LECTINS; MASS SPECTROMETRY; MUTATION; NEOPLASM PROTEINS; POLYSACCHARIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEINS; PROTEOLYSIS; RNA INTERFERENCE; UBIQUITIN-PROTEIN LIGASES;

METAZOA;

EID: 84871197818     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-06-0428     Document Type: Article

References (49)

1. Berditchevski F, Chang S, Bodorova J, Hemler ME (1997). Generation of monoclonal antibodies to integrin-associated proteins. J Biol Chem 272, 29174-29180.
2. Bernasconi R, Galli C, Calanca V, Nakajima T, Molinari M (2010). Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates. J Cell Biol 188, 223-235.
3. Bonifacino JS, Cosson P, Klausner RD (1990). Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains. Cell 63, 503-513.
4. Bonifacino JS, Cosson P, Shah N, Klausner RD (1991). Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum. EMBO J 10, 2783-2793.
5. Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM, Lehner PJ (2011). HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc Natl Acad Sci USA 108, 2034-2039.
6. Catanzariti AM, Soboleva TA, Jans DA, Board PG, Baker RT (2004). An efficient system for high-level expression and easy purification of authentic recombinant proteins. Protein Sci 13, 1331-1339.
7. Chen B, Mariano J, Tsai YC, Chan AH, Cohen M, Weissman AM (2006). The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc Natl Acad Sci USA 103, 341-346.
8. Chen C, Bonifacino JS, Yuan LC, Klausner RD (1988). Selective degradation of T cell antigen receptor chains retained in a pre-Golgi compartment. J Cell Biol 107, 2149-2161.
9. Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A (2011). Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol 192, 825-838.
10. Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Harper JW, Kopito RR (2012). Defining human ERAD networks through an integrative mapping strategy. Nat Cell Biol 14, 93-105.
11. Christianson JC, Shaler TA, Tyler RE, Kopito RR (2008). OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol 10, 272-282.
12. Cosson P, Lankford SP, Bonifacino JS, Klausner RD (1991). Membrane protein association by potential intramembrane charge pairs. Nature 351, 414-416.
13. Denic V, Quan EM, Weissman JS (2006). A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell 126, 349-359.
14. Elbein AD, Tropea JE, Mitchell M, Kaushal GP (1990). Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J Biol Chem 265, 15599-15605.
15. Fanelli A, Grollman EF, Wang D, Philp NJ (2003). MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells. Am J Phys Endocrinol Metab 285, E1223-E1229.
16. Fleig L, Bergbold N, Sahasrabudhe P, Geiger B, Kaltak L, Lemberg MK (2012). Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins. Mol Cell 47, 558-569.
17. Fossum S, Mallett S, Barclay AN (1991). The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence. Eur J Immunol 21, 671-679.
18. Gallagher SM, Castorino JJ, Wang D, Philp NJ (2007). Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res 67, 4182-4189.
19. Gelman MS, Kannegaard ES, Kopito RR (2002). A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator. J Biol Chem 277, 11709-11714.
20. Ghaemmaghami S, Huh W-K, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS (2003). Global analysis of protein expression in yeast. Nature 425, 737-741.
21. Hammond C, Helenius A (1995). Quality control in the secretory pathway. Curr Opin Cell Biol 7, 523-529.
22. Helenius A, Aebi M (2004). Roles of N-linked glycans in the endoplasmic reticulum. Annu Rev Biochem 73, 1019-1049.
23. Hurtley SM, Helenius A (1989). Protein oligomerization in the endoplasmic reticulum. Annu Rev Cell Biol 5, 277-307.
24. Iacono KT, Brown AL, Greene MI, Saouaf SJ (2007). CD147 immunoglobulin superfamily receptor function and role in pathology. Exp Mol Pathol 83, 283-295.
25. Kingston RE, Chen CA, Rose JK (2001). Calcium phosphate transfection. Curr Protoc Mol Biol 63, 9.1.1-9.1.11.
26. Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP (2000). CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 19, 3896-3904.
27. Kisselev AF, van der Linden WA, Overkleeft HS (2012). Proteasome inhibitors: an expanding army attacking a unique target. Chem Biol 19, 99-115.
28. Lankford SP, Cosson P, Bonifacino JS, Klausner RD (1993). Transmembrane domain length affects charge-mediated retention and degradation of proteins within the endoplasmic reticulum. J Biol Chem 268, 4814-4820.
29. Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J (2011). CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci USA 108, 16663-16668.
30. Manoharan C, Wilson MC, Sessions RB, Halestrap AP (2006). The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. Mol Membr Biol 23, 486-498.
31. Meunier L, Usherwood YK, Chung KT, Hendershot LM (2002). A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol Biol Cell 13, 4456-4469.
32. Mueller B, Klemm EJ, Spooner E, Claessen JH, Ploegh HL (2008). SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci USA 105, 12325-12330.
33. Ragg H (2007). The role of serpins in the surveillance of the secretory pathway. Cell Mol Life Sci 64, 2763-2770.
34. Ryu KY, Baker RT, Kopito RR (2006). Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens. Anal Biochem 353, 153-155.
35. Sato BK, Schulz D, Do PH, Hampton RY (2009). Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell 34, 212-222.
36. Satoh T, Chen Y, Hu D, Hanashima S, Yamamoto K, Yamaguchi Y (2010). Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation. Mol Cell 40, 905-916.
37. Schlabach MR et al. (2008). Cancer proliferation gene discovery through functional genomics. Science 319, 620-624.
38. Shin J, Lee S, Strominger JL (1993). Translocation of TCR alpha chains into the lumen of the endoplasmic reticulum and their degradation. Science 259, 1901-1904.
39. Smith MH, Ploegh HL, Weissman JS (2011). Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science 334, 1086-1090.
40. Sun J, Hemler ME (2001). Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res 61, 2276-2281.
41. Tang W, Chang SB, Hemler ME (2004). Links between CD147 function, glycosylation, and caveolin-1. Mol Biol Cell 15, 4043-4050.
42. Ullah MS, Davies AJ, Halestrap AP (2006). The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281, 9030-9037.
43. Ward CL, Kopito RR (1994). Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins. J Biol Chem 269, 25710-25718.
44. Wilson MC, Meredith D, Halestrap AP (2002). Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ. J Biol Chem 277, 3666-3672.
45. Wiznerowicz M, Trono D (2003). Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol 77, 8957-8961.
46. Hong Kong via the C-terminal MRH domain in a glycan-dependent manner. Glycobiology 20, 348-355.
47. Ye Y, Shibata Y, Kikkert M, van Voorden S, Wiertz E, Rapoport TA (2005). Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci USA 102, 14132-14138.
48. Yu H, Kaung G, Kobayashi S, Kopito RR (1997). Cytosolic degradation of T-cell receptor α chains by the proteasome. J Biol Chem 272, 20800-20804.
49. Yu X-L, Jiang J-L, Li L, Feng Q, Xu J, Chen Z-N (2006). The glycosylation characteristic of hepatoma-associated antigen HAb18G/CD147 in human hepatoma cells. Int J Biochem Cell Biol 38, 1939-1945.