Medical treatment of acute poisoning with organophosphorus and carbamate pesticides

Toxicology Letters

Volumn 190, Issue 2, 2009, Pages 107-115

  Jokanović, Milan ^a,b  

^a University of Nish   (Serbia)

^b Academy of Sciences and Arts of Republic Srpska   (Bosnia and Herzegovina)

Author keywords

Acetylcholinesterase; Antidotes; Atropine; Carbamates; Diazepam; HI 6; Medical treatment; Obidoxime; Organophosphorus compounds; Pesticides; Pralidoxime; Pyridinium oximes; Trimedoxime; Warfare nerve agents

Indexed keywords

ACTIVATED CARBON; AMINOTRANSFERASE; ANTIDOTE; ASOXIME; ATROPINE; BENZODIAZEPINE DERIVATIVE; BIS(PYRIDINIUM OXIME) DERIVATIVE; CARBAMATE PESTICIDE; CHLORPYRIFOS; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DIAZEPAM; DIMETHOATE; DRUG METABOLITE; ETHOPROP; FENAMIPHOS; FENTHION; MALATHION; MONOPYRIDINIUM OXIME DERIVATIVE; OBIDOXIME; ORGANOPHOSPHATE PESTICIDE; PARATHION METHYL; PRALIDOXIME; PRALIDOXIME CHLORIDE; PRALIDOXIME IODIDE; PROFENOFOS; PYRIDAPHENTHION; PYRIDINIUM OXIME DERIVATIVE; TRIMEDOXIME; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABSENCE OF SIDE EFFECTS; ACCOMMODATION; ACUTE TOXICITY; AMINOTRANSFERASE BLOOD LEVEL; BLOOD BRAIN BARRIER; BLURRED VISION; BRAIN DAMAGE; BURNING SENSATION; CHOLESTASIS; CHOLINERGIC TRANSMISSION; CLINICAL ASSESSMENT; CLINICAL FEATURE; CLINICAL TRIAL; CONSERVATIVE TREATMENT; CONTINUOUS INFUSION; CONVULSION; DIPLOPIA; DISEASE SEVERITY; DIZZINESS; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG MEGADOSE; DRUG OVERDOSE; DRUG PENETRATION; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REACTIVATION; ENZYME SUBSTRATE; HUMAN; JAUNDICE; LIVER TOXICITY; LOADING DRUG DOSE; LOW DRUG DOSE; MORBIDITY; MORTALITY; NAUSEA; NEUROLOGIC DISEASE; NONHUMAN; PALLOR; PARESTHESIA; PRIORITY JOURNAL; PROTEIN INTERACTION; RECOMMENDED DRUG DOSE; REPEATED DRUG DOSE; REVIEW; SEIZURE; SIDE EFFECT; SINGLE DRUG DOSE; SORE THROAT; STOMACH LAVAGE; SYMPTOM; TOXICOKINETICS; WEAKNESS;

ACUTE DISEASE; ANIMALS; ANTIDOTES; CARBAMATES; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; PESTICIDES; POISONING;

EID: 69749118203     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.07.025     Document Type: Review

References (67)

1. Abdel-Rahman A., Shetty A.K., and Abou-Donia M. Acute exposure to sarin increases blood brain barrier permeability and induces neuropathological changes in the rat brain: dose-response relationships. Neuroscience 113 (2002) 721-741
2. Antonijević B., and Stojiljković M.P. Unequal efficacy of pyridinium oximes in acute organophosphorus poisoning. Clin. Med. Res. 5 (2007) 71-78
3. Aragao I., Soares M.E., Bastos M.L., and Lopes M. Continuous infusion of obidoxime and the importance of plasma levels monitoring in organophosphate poisoning. Intensive Care Med. 22 Suppl. 3 (1996) S388, 512
4. Ashani Y., Bhattacharjee A.K., Leader H., Saxena A., and Doctor B.P. Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators. Biochem. Pharmacol. 66 (2003) 191-202
5. Balali-Mood M., and Shariat M. Treatment of organophosphate poisoning. Experience of nerve agents and acute pesticide poisoning on the effects of oximes. J. Physiol. Paris 92 (1998) 375-378
6. Baron R.L. Carbamate insecticides. In: Hayes W.J., and Laws Jr. E.R. (Eds). Handbook of Pesticide Toxicology vol. 3 (1991), Academic Press, Inc., San Diego 1129
7. Bismuth C., Inns R.H., and Marrs T.C. Efficacy, toxicity and clinical use of oximes in anticholinesterase poisoning. In: Ballantyne B., and Marrs T.C. (Eds). Clinical & Experimental Toxicology of Organophosphates & Carbamates (1992), Butterworth-Heinemann, Oxford 555-577
8. Bokonjić D., Jovanović D., Jokanović M., and Maksimović M. Protective effects of oximes HI-6 and PAM-2 applied by osmotic minipumps in quinalphos-poisoned rats. Arch. Int. Pharmacodyn. 288 (1987) 309-318
9. Bošković B., Vojvodić V., Maksimović M., Granov A., Besarović-Lazarev S., and Binenfeld Z. Effect of mono and bis-quaternary pyridinium oximes on the serum cholinesterase inhibitory activity of dioxacarb, carbaryl and carbofuran. Arh. Hig. Rada 27 (1976) 289-295
10. Burgess J.L., Bernstein J.N., and Hurlbut K. Aldicarb poisoning. A case report with prolonged cholinesterase inhibition and improvement after pralidoxime therapy. Arch. Int. Med. 154 (1994) 221-224
11. Carpentier P., Delamanch I., Le Bert M., Blanchet G., and Bouchard C. Seizure-related opening of the blood-brain barrier induced by soman: possible correlation with the acute neuropathology observed in poisoned rats. Neurotoxicology 11 (1990) 493-508
12. Cherian M.A., Roshini C., Peter J.V., and Cherian A.M. Oximes in organophosphorus poisoning. Indian J. Crit. Care Med. 9 (2005) 155-163
13. Darvesh S., Hopkins D.A., and Geula C. Neurobiology of butyrylcholinesterase. Nat. Rev. Neurosci. 4 (2003) 131-138
14. Dawson R.M. Oxime effects on the rate constants of carbamylation and decarbamylation of acetylcholinesterase for pyridine, physostigmine and insecticidal carbamates. Neurochem. Int. 26 (1995) 643-654
15. De Silva H.J., Wijewickrema R., and Senanayake N. Does pralidoxime affect outcome of management in acute organophosphate poisoning?. Lancet 339 (1992) 1136-1138
16. Eddleston M., Juszczak E., and Buckley N.A. Randomised controlled trial of routine single or multiple dose superactivated charcoal for self-poisoning in a region with high mortality. Clin. Toxicol. 43 (2005) 442-443
17. Eddleston M., Eyer P., Worek F., Mohamed F., Senarathna L., von Meyer L., Juszczak E., Hittarage A., Azhar S., Dissanayake W., Sheriff M.H.R., Szinicz L., Dawson A.H., and Buckley N.A. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet 366 (2005) 1452-1459
18. Eddleston M., Singh S., and Buckley N. Organophosphorus poisoning (acute). Clin. Evid. 15 (2006) 1-13
19. Eddleston M., Juszczak E., Buckley N.A., Senarathna L., Mohamed F., Dissanayake W., Hittarage A., Azher S., Jeganathan K., Jayamanne S., Sheriff M.H.R., and Warrell D.A. Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. Lancet 371 (2008) 579-587
20. Eyer P. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicol. Rev. 22 (2003) 165-190
21. Garber M. Carbamate poisoning: the 'other' insecticide. Pediatrics 79 (1987) 734-738
22. Grange-Messent V., Bouchaud C., Jamme M., Lallement G., Foguin A., and Carpentier P. Seizure-related opening of the blood-brain barrier produced by the anticholinesterase compound, soman: new ultrastructural observations. Cell Mol. Biol. 45 (1999) 1-14
23. IPCS. Organophosphorus pesticides. International Programme on Chemical Safety Poisons Information Monograph G001 (1989), World Health Organization, Geneva. http://www.inchem.org/documents/pims/chemical/pimg001.htm Updated 1998. Available online at: http://www.inchem.org/documents/pims/chemical/pimg001.htm
24. IPCS. Antidotes for poisoning by organophosphorus pesticides. Monograph on Atropine. International Programme on Chemical Safety Evaluation. World Health Organization, Geneva (2002)
25. Jagger B.V., and Stagg G.N. Toxicity of diacetylmonoxime and of pyridine-2-aldoxime methiodide in man 15-30 mg/kg 2-PAM: no effects on EEG in a healthy man. Bull. Johns Hopkins Hosp. 102 (1958) 203-211
26. Johnson M.K., and Vale J.A. Clinical management of acute organophosphate poisoning: an overview. In: Ballantyne B., and Marrs T.C. (Eds). Clinical & Experimental Toxicology of Organophosphates & Carbamates (1992), Butterworth-Heinemann, Oxford 528-535
27. Johnson M.K., Jacobsen D., Meredith T.J., Eyer P., Heath A.J., Ligtenstein D.A., Marrs T.C., Szinicz L., Vale A.J., and Haines J.A. Evaluation of antidotes for poisoning by organophosphorus pesticides. Emerg. Med. 12 (2000) 22-37
28. Johnson S., Peter J.V., Thomas K., Jeyaseelan L., and Cherian A.M. Evaluation of two treatment regimens of pralidoxime (1 gm single bolus dose vs 12 gm infusion) in the management of organophosphorus poisoning. J. Assoc. Physicians India 44 (1996) 529-531
29. Jokanović M., and Maksimović M. A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in treatment of oral organophosphorus insecticide poisoning. Arch. Toxicol. 70 (1995) 119-123
30. Jokanović M., and Maksimović M. Abnormal cholinesterase activity: understanding and interpretation. Eur. J. Clin. Chem. Clin. Biochem. 35 (1997) 11-16
31. Jokanović M. Biotransformation of organophosphorus compounds. Toxicology 166 (2001) 139-160
32. Jokanović M., and Stojiljković M.P. Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning. Eur. J. Pharmacol. 553 (2006) 10-17
33. Jokanović M., and Prostran M. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Curr. Med. Chem. 16 (2009) 2177-2188
34. Jovanović D., Maksimović M., Joksović D., and Kovačević V. Oral forms of the oxime HI-6: a study of pharmacokinetics and tolerance after administration to healthy volunteers. Vet. Hum. Toxicol. 32 (1990) 419-421
35. Karchmar A.G. Anticholinesterases and war gases. In: Karchmar A.G. (Ed). Exploring the Vertebrate Central Cholinergic Nervous System (2007), Springer 237-310
36. Kassa J. The role of oximes in the antidotal treatment of chemical casualties exposed to nerve agents. In: Monov A., and Dishovsky C. (Eds). Medical Aspects of Chemical and Biological Terrorism: Chemical Terrorism and Traumatism (2005), Publishing House of the Union of Scientists in Bulgaria, Sofia, Bulgaria 193-208. http://www.jmedchemdef.org/archives.html (Available at http://www.jmedchemdef.org/archives.html)
37. Kušić R., Bošković B., Vojvodić V., and Jovanović D. HI-6 in man: blood levels, urinary excretion, and tolerance after intramuscular administration of the oxime to healthy volunteers. Fundam. Appl. Toxicol. 5 (1985) S89-S97
38. Kušić R., Jovanović D., Rand{combining short stroke overlay}elović S., Joksović D., Todorović V., Bošković B., Jokanović M., and Vojvodić V. HI-6 in man: efficacy of the oxime in poisoning by organophosphorus insecticides. Hum. Exp. Toxicol. 10 (1991) 113-118
39. Lieske C.N., Clark J.H., Maxwell D.M., Zoeffel L.D., and Sultan W.E. Studies of the amplification of carbaryl toxicity by various oximes. Toxicol. Lett. 62 (1992) 127-137
40. Luo C., Saxena A., Smith M., Garcia G., Radić Z., Taylor P., and Doctor B.P. Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium. Biochemistry 38 (1999) 9937-9947
41. Marrs T.C. Diazepam. Antidotes for Poisoning by Organophosphorus Pesticides (2004), International Programme on Chemical Safety, World Health Organization, Geneva
42. Marrs T.C., and Vale J.A. Management of organophosphorus pesticide poisoning. In: Gupta R.C. (Ed). Toxicology of Organophosphorus and Carbamate Compounds (2006), Elsevier Academic Press, Amsterdam 715-733
43. Mason H.J., Sams C., Stevenson A.J., and Rawborne R. Rates of spontaneous reactivation and aging of acetylcholinesterase in human erythrocytes after inhibition by organophosphorus pesticides. Hum. Exp. Toxicol. 19 (2000) 511-516
44. McDonough Jr. J.H., McLeod Jr. C.G., and Nipwoda M.D. Direct micro-injection of soman or VX into the amygdala produces repetitive limbic convulsions and neuropathology. Brain Res. 435 (1987) 123-137
45. Milatović D., and Jokanović M. Pyridinium oximes as cholinesterase reactivators in the treatment of poisoning with organophosphorus compounds. In: Gupta R.C. (Ed). Handbook of Toxicology of Chemical Warfare Agents (2009), Elsevier 985-996
46. Pazdernik T.L., Nelson S.R., Cross R., Churchill L., Giesler M., and Samson F.E. Effects of antidotes on soman-induced brain damage. Arch. Toxicol. 9 (1986) 333-336
47. Pawar K.S., Bhoite R.R., Pillay C.P., Chavan S.C., Malshikare D.S., and Garad S.G. Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial. Lancet 368 (2006) 2136-2141
48. Peng A., Meng F.-Q., Sun L.-F., Ji Z.-S., and Li Y.-H. Therapeutic efficacy of charcoal hemoperfusion in patients with acute severe dichlorvos poisoning. Acta Pharmacol. Sin. 25 (2004) 15-21
49. Reiner E., and Pleština R. Regeneration of cholinesterase activities in humans and rats after inhibition by O,O-dimethyl-O-dimethyl-2,2-dichlorvinyl phosphate. Toxicol. Appl. Pharmacol. 49 (1979) 451-454
50. Rotenberg M., Shefi M., Dany S., Dore I., Tirosh M., and Almog S. Differentiation between organophosphate and carbamate poisoning. Clin. Chim. Acta 234 (1995) 11-21
51. Sakurada K., Matsubara K., Shimizu K., Shiono H., Seto Y., Tsuge K., Yoshino M., Sakai I., Mukoyama H., and Takatori T. Pralidoxime iodide (2-PAM) penetrates accross the blood-brain barrier. Neurochem. Res. 28 (2003) 1401-1407
52. Sellström A. Anticonvulsants in anticholinesterase poisoning. In: Ballantyne B., and Marrs T.C. (Eds). Clinical & Experimental Toxicology of Organophosphates & Carbamates (1992), Butterworth-Heinemann, Oxford 578-586
53. Shiloff J.D., and Clement J.G. Comparison of serum concentration of the acetylcholinesterase oxime reactivatiors HI-6, obidoxime and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats. Toxicol. Appl. Pharmacol. 89 (1987) 278-280
54. Shrot S., Markel G., Dushnitsky T., and Krivoy A. The possible use of oximes as antidotal therapy in organophosphate-induced brain damage. Neurotoxicology 30 (2009) 167-173
55. Sidell F.R., and Groff W.A. Toxogonin: blood levels and side effects after intramuscular administration in man. J. Pharm. Sci. 59 (1970) 793-797
56. Sidell F.R., and Groff W.A. Intramuscular and intravenous administration of small doses of 2-pyridinium aldoxime methochloride to man. J. Pharm. Sci. 60 (1971) 1224-1228
57. Simon F.A., and Pickering L.K. Acute yellow phosphorus poisoning: "smoking stool syndrome". J. Am. Med. Assoc. 235 (1976) 1343-1344
58. Singh S., Batra Y.K., Singh S.M., Wig N., and Sharma B.K. Is atropine alone sufficient in acute severe organophosphate poisoning? Experience of a North West Indian hospital. Int. J. Clin. Pharmacol. Ther. 33 (1995) 628-630
59. Sterri S.H., Rognerud B., Fiskum S.E., and Lyngaas S. Effect of toxogonin and P2S on the toxicity of carbamates and organophosphorus compounds. Acta Pharmacol. Toxicol. 45 (1979) 9-15
60. Stojiljković M.P., and Jokanović M. AUM Shinrikyo and terrorist use of nerve agents in Japan. In: Monov A., and Dishovsky C. (Eds). Medical Aspects of Chemical and Biological Terrorism: Chemical Terrorism and Traumatism (2005), Publishing House of the Union of Scientists in Bulgaria, Sofia, Bulgaria 101-115. http://www.jmedchemdef.org/archives.html (Available at http://www.jmedchemdef.org/archives.html)
61. Thiermann H., Mast U., Klimmek R., Eyer P., Hibler A., Pfab R., Felgenhauer N., and Zilker T. Cholinesterase status, pharmacokinetics, and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum. Exp. Toxicol. 16 (1997) 473-480
62. Thiermann H., Szinicz L., Eyer F., Worek F., Eyer P., Felgenhauer N., and Zilker T. Modern strategies in therapy of organophosphate poisoning. Toxicol. Lett. 107 (1999) 233-239
63. Willems J.L., De Bisschop H.C., Verstraete A.G., Declerck C., Christiaens Y., Vanscheeuwyck P., Buylaert W.A., Vogelaers D., and Colardyn F. Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate. Arch. Toxicol. 67 (1993) 79-84
64. Worek F., and Diepold C. Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics. Arch. Toxicol. 73 (1999) 7-14
65. Worek F., Eyer P., Aurbek N., Szinicz L., and Thiermann H. Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis. Toxicol. Appl. Pharmacol. 219 (2007) 226-234
66. World Health Organization. Organophosphorus Insecticides: A General Introduction vol. 63 (1986), Environmental Health Criteria, Geneva
67. Zilker T. Medical management of incidents with chemical warfare agents. Toxicology 214 (2005) 221-231