Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 147-152

  Abuhaie, Cristina Maria ^a   Bîcu, Elena ^a   Rigo, Benoît ^b,c   Gautret, Philippe ^b,c   Belei, Dalila ^a   Farce, Amaury ^b,d   Dubois, Joëlle ^e   Ghinet, Alina ^a,b,c  

^a ALEXANDRU IOAN CUZA UNIVERSITY OF IASI   (Romania)

^b UNIV LILLE   (France)

^c UNIVERSITÉ CATHOLIQUE DE LILLE   (France)

^d Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^e INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

Author keywords

Anticancer agent; Microtubule targeting agent; Phenothiazine derivative; Tubulin

Indexed keywords

ANTINEOPLASTIC AGENT; PHENOTHIAZINE A; PHENOTHIAZINE DERIVATIVE; PHENSTATIN; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; DRUG INTERACTION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE; PROTEIN POLYMERIZATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MOLECULAR DOCKING SIMULATION; PHENOTHIAZINES; POLYMERIZATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 84870997500     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.135     Document Type: Article

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