Synthesis and biological evaluation of phenstatin metabolites

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 20, 2011, Pages 6042-6054

  Ghinet, Alina ^a,b   Rigo, Benoît ^a,b   Hénichart, Jean Pierre ^a   Le Broc Ryckewaert, Delphine ^a   Pommery, Jean ^a   Pommery, Nicole ^a   Thuru, Xavier ^c   Quesnel, Bruno ^c,d,e   Gautret, Philippe ^a,b  

^a UNIV LILLE   (France)

^b Ecole des Hautes Etudes d'Ingenieur   (France)

^c Institut de Recherche sur le Cancer de Lille   (France)

^d Institut de Médecine Prédictive et de Recherche Thérapeutique   (France)

^e LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Anticancer agent; Eaton's reagent; Friedel Crafts acylation; Metabolite; Murine leukemia; Phenstatin; Tubulin

Indexed keywords

(3 HYDROXY 2,4 DIMETHOXYPHENYL) (3,4,5 TRIMETHOXYPHENYL)METHANONE; (3 HYDROXY 2,4 DIMETHOXYPHENYL) (4 METHOXYPHENYL)METHANONE; (3 HYDROXY 2,4 DIMETHOXYPHENYL)(4 HYDROXY 3,5 DIMETHOXYPHENYL)METHANONE; (3 HYDROXY 4 METHOXYPHENYL) (3,4,5 TRIMETHOXYPHENYL)METHANONE; (3 HYDROXY 4,5 DIMETHOXYPHENYL)(3 HYDROXY 4 METHOXYPHENYL)METHANONE; (3,4 DIHYDROXYPHENYL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (3,4 DIMETHOXYPHENYL)(3,4,5 TRIMETHOXYPHENYL)METHANOL; (3,4 DIMETHOXYPHENYL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (3,4 DIMETHOXYPHENYL)(4 HYDROXY 3,5 METHOXYPHENYL)METHANONE; (4 AMINO 3 HYDROXYPHENYL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (4 HYDROXY 3,5 DIMETHOXYPHENYL)(3 HYDROXY 4 METHOXYPHENYL)METHANONE; 1 HYDROXY 2,3,5,6,7 PENTAMETHOXYANTHRA 9,10 QUINONE; 2 METHOXY 5 (3,4,5 TRIMETHOXYBENZOYL)PHENYL CHLOROACETATE; 2' METHOXYPHENASTINE; 2,6 DIMETHOXY 3 (3,4,5 TRIMETHOXYBENZOYL)PHENYL CHLOROACETATE; 2,6 DIMETHOXY 3 (4 METHOXYBENZOYL)PHENYL CHLOROACETATE; 3 (METHYLSULFONYL) 6 (3,4,5 TRIMETHOBENZOYL) 1,3 BENZOXAZOL 2(3H) ONE; 3 [4 [(ETHOXYCARBONYL)OXY] 3,5 DIMETHOXYBENZOYL] 2,6 DIMETHOXYPHENYL CHLOROACETATE; 4 (3,4 DIMETHOXYBENZOYL) 2,6 DIMETHOXYPHENYL ETHYL CARBONATE; 5 (3,4,5 TRIMETHOXYBENZOYL) 1,3 BENZODIOXOL 2 ONE; 5 [4 [(ETHOXYCARBONYL)OXY] 3,5 DIMETHOXYBENZOYL] 2 METHOXYPHENYL CHLOROACETATE; 5 [HYDROXY (3,4,5 TRIMETHOXYPHENYL)METHYL] 2 METHOXYPHENOL; 6 (3,4,5 TRIMETHOXYBENZOYL) 1,3 BENZOXAZOL 2(3H) ONE; ANTINEOPLASTIC AGENT; COMBRETASTATIN A1 PHOSPHATE; COMBRETASTATIN A4; ETHYL 4 (3 HYDROXY 2,4 DIMETHOXYBENZOYL) 2,6 DIMETHOXYPHENYL CARBONATE; ETHYL 4 (3 HYDROXY 4 METHOXYBENZOYL) 2,6 DIMETHOXYPHENYL CARBONATE; N [2,6 DIMETHOXY 3 (3,4,5 TRIMETHOXYBENZOYL)PHENYL]ACETAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOPHENONES; CELL GROWTH PROCESSES; CELL LINE, TUMOR; HUMANS; MICE; MICROTUBULES; PHOSPHORIC ACID ESTERS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

MURINAE; RATTUS;

EID: 80053248567     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.047     Document Type: Article

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