Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization

Journal of Medicinal Chemistry

Volumn 50, Issue 9, 2007, Pages 2273-2277

  Romagnoli, Romeo ^a   Baraldi, Pier Giovanni ^a   Carrion, Maria Dora ^a   Cara, Carlota Lopez ^a   Preti, Delia ^a   Fruttarolo, Francesca ^a   Pavani, Maria Giovanna ^a   Tabrizi, Mojgan Aghazadeh ^a   Tolomeo, Manlio ^b   Grimaudo, Stefania ^b   Di Cristina, Antonella ^b   Balzarini, Jan ^c   Hadfield, John A ^d   Brancale, Andrea ^e   Hamel, Ernest ^f  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d UNIVERSITY OF SALFORD   (United Kingdom)

^e CARDIFF UNIVERSITY   (United Kingdom)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 METHYL 3 (3,4,5 TRIMETHOXYBENZOYL)BENZO[B]THIOPHENE; ANTIMITOTIC AGENT; BENZOTHIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN;

ANIMALS; ANTIMITOTIC AGENTS; BINDING SITES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COLCHICINE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; PROTEIN BINDING; RADIOLIGAND ASSAY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TUBULIN; TUBULIN MODULATORS;

EID: 34247631534     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070050f     Document Type: Article

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