Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 13, 2007, Pages 3613-3617

  Hu, Laixing ^a,b   Jiang, Jian dong ^b   Qu, Jinrong ^c   Li, Yan ^c   Jin, Jie ^b   Li, Zhuo rong ^b   Boykin, David W ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Antiproliferative; Heterocyclic ketones; Solid tumors; Tubulin

Indexed keywords

(N 1 METHYLINDOL 5 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; ANTINEOPLASTIC AGENT; KETONE DERIVATIVE; SULFONAMIDE; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CELL LINE; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; METASTASIS INHIBITION; STRUCTURE ACTIVITY RELATION;

ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; KETONES; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TUBULIN;

EID: 34250170875     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.048     Document Type: Article

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