Frequent Alteration of the Tumor Suppressor Gene APC in Sporadic Canine Colorectal Tumors

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Youmans, Lydia ^a   Taylor, Cynthia ^a   Shin, Edwin ^a   Harrell, Adrienne ^a   Ellis, Angela E ^b   Séguin, Bernard ^c   Ji, Xinglai ^d   Zhao, Shaying ^a  

^a University of Georgia   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c OREGON STATE UNIVERSITY   (United States)

^d YUNNAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APC GENE; ARTICLE; BASEMENT MEMBRANE; BINDING SITE; CARCINOGENESIS; CODON; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; COLORECTAL TUMOR; CONTROLLED STUDY; DOG; EXON; GENE CLUSTER; GENE DELETION; GENE DISRUPTION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; IMMUNOHISTOCHEMISTRY; MISSENSE MUTATION; MOLECULAR DYNAMICS; NONHUMAN; OLIGOMERIZATION; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADENOMA; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; COLON; COLORECTAL NEOPLASMS; DOG DISEASES; DOGS; MUTATION;

CANIS FAMILIARIS;

EID: 84870950451     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050813     Document Type: Article

References (44)

1. Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, et al. (2005) Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438: 803-819.
2. Holstege H, van Beers E, Velds A, Liu X, Joosse SA, et al. (2010) Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers. BMC Cancer 10: 455.
3. Rowell JL, McCarthy DO, Alvarez CE, (2011) Dog models of naturally occurring cancer. Trends Mol Med 17: 380-388.
4. Paoloni M, Khanna C, (2008) Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer 8: 147-156.
5. Khanna C, Lindblad-Toh K, Vail D, London C, Bergman P, et al. (2006) The dog as a cancer model. Nat Biotechnol 24: 1065-1066.
6. Argyle DJ, (2005) The benefits of comparative medicine - a hundred years to come to our senses. Vet J 170: 147-148.
7. Leroy BE, Northrup N, (2009) Prostate cancer in dogs: comparative and clinical aspects. Vet J 180: 149-162.
8. Michell AR, (2005) Comparative clinical science: The medicine of the future. Vet J 170: 153-162.
9. Parker HG, Shearin AL, Ostrander EA, (2010) Man's best friend becomes biology's best in show: genome analyses in the domestic dog. Annu Rev Genet 44: 309-336.
10. Pontius JU, Mullikin JC, Smith DR, Lindblad-Toh K, Gnerre S, et al. (2007) Initial sequence and comparative analysis of the cat genome. Genome Res 17: 1675-1689.
11. Mullikin JC, Hansen NF, Shen L, Ebling H, Donahue WF, et al. (2010) Light whole genome sequence for SNP discovery across domestic cat breeds. BMC Genomics 11: 406.
12. Ji X, Zhao S, (2008) DA and Xiao-two giant and composite LTR-retrotransposon-like elements identified in the human genome. Genomics 91: 249-258.
13. Ledford H, (2010) Big science: The cancer genome challenge. Nature 464: 972-974.
14. Haber DA, Settleman J, (2007) Cancer: drivers and passengers. Nature 446: 145-146.
15. Tang J, Le S, Sun L, Yan X, Zhang M, et al. (2010) Copy number abnormalities in sporadic canine colorectal cancers. Genome Res 20: 341-350.
16. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330-337.
17. Kinzler KW, Vogelstein B, (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170.
18. Lengauer C, Kinzler KW, Vogelstein B, (1998) Genetic instabilities in human cancers. Nature 396: 643-649.
19. Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C, (2003) The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer 3: 695-701.
20. Camps J, Grade M, Nguyen QT, Hormann P, Becker S, et al. (2008) Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome. Cancer Res 68: 1284-1295.
21. Fearon ER, (2011) Molecular genetics of colorectal cancer. Annu Rev Pathol 6: 479-507.
22. Taketo MM, Takaku K, (2000) Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Hum Cell 13: 85-95.
23. Ji X, Tang J, Halberg R, Busam D, Ferriera S, et al. (2010) Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study. BMC Cancer 10: 426.
24. Fishel R, Groden J, (2008) Harnessing mismatch repair to model sporadic cancers. Nat Methods 5: 225-226.
25. Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, et al. (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75: 1027-1038.
26. Jin B, Yao B, Li JL, Fields CR, Delmas AL, et al. (2009) DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. Cancer Res 69: 7412-7421.
27. Habermann JK, Brucker CA, Freitag-Wolf S, Heselmeyer-Haddad K, Kruger S, et al. (2011) Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma. Mod Pathol 24: 542-555.
28. Loboda A, Nebozhyn MV, Watters JW, Buser CA, Shaw PM, et al. (2011) EMT is the dominant program in human colon cancer. BMC Med Genomics 4: 9.
29. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274.
30. Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, et al. (1992) Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1: 229-233.
31. Rowan AJ, Lamlum H, Ilyas M, Wheeler J, Straub J, et al. (2000) APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". Proc Natl Acad Sci U S A 97: 3352-3357.
32. Laurent-Puig P, Beroud C, Soussi T, (1998) APC gene: database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res 26: 269-270.
33. Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, et al. (1999) Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 18: 3098-3103.
34. Restucci B, Martano M, De Vico G, Lo Muzio L, Maiolino P, (2009) Expression of E-cadherin, beta-catenin and APC protein in canine colorectal tumours. Anticancer Res 29: 2919-2925.
35. McEntee MF, Brenneman KA, (1999) Dysregulation of beta-catenin is common in canine sporadic colorectal tumors. Vet Pathol 36: 228-236.
36. Chang MY, Boulden J, Katz JB, Wang L, Meyer TJ, et al. (2007) Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer. Cancer Res 67: 7605-7612.
37. Ma L, Westbroek A, Jochemsen AG, Weeda G, Bosch A, et al. (1994) Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function. Mol Cell Biol 14: 4126-4134.
38. Shibata H, Takano H, Ito M, Shioya H, Hirota M, et al. (2007) Alpha-catenin is essential in intestinal adenoma formation. Proc Natl Acad Sci U S A 104: 18199-18204.
39. Vonholdt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, et al. (2010) Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature 464: 898-902.
40. Alvarez CE, Akey JM, (2012) Copy number variation in the domestic dog. Mamm Genome 23: 144-163.
41. Berglund J, Nevalainen EM, Molin AM, Perloski M, Lupa TL, et al. (2012) Novel origins of copy number variation in the dog genome. Genome Biol 13: R73.
42. Fearnhead NS, Britton MP, Bodmer WF, (2001) The ABC of APC. Hum Mol Genet 10: 721-733.
43. Aresu L, Pregel P, Zanetti R, Caliari D, Biolatti B, et al. (2010) E-cadherin and beta-catenin expression in canine colorectal adenocarcinoma. Res Vet Sci 89: 409-414.
44. Crist RC, Roth JJ, Baran AA, McEntee BJ, Siracusa LD, et al. (2010) The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. Mamm Genome 21: 450-457.