Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma

Modern Pathology

Volumn 24, Issue 4, 2011, Pages 542-555

  Habermann, Jens K ^a,b,c   Brucker, Constanze A ^a,c   Freitag Wolf, Sandra ^d   Heselmeyer Haddad, Kerstin ^c   Krüger, Stefan ^a   Barenboim, Linda ^c   Downing, Tricia ^c   Bruch, Hans Peter ^a   Auer, Gert ^b   Roblick, Uwe J ^a,b   Ried, Thomas ^c  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

amplifications; colorectal adenomas; colorectal carcinogenesis; deletions; genomic instability

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MYC PROTEIN; PROTEIN P53; RAB20 PROTEIN; SMAD7 PROTEIN; STEROID RECEPTOR COACTIVATOR 3; UNCLASSIFIED DRUG;

ADULT; AGED; ANEUPLOIDY; ARTICLE; CANCER DIAGNOSIS; CANCER PATIENT; CANCER RECURRENCE; CANCER RISK; CENTROMERE; CHROMOSOME 17; CHROMOSOME 18; CLINICAL ARTICLE; COLORECTAL ADENOMA; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DELETION; GENE DOSAGE; GENOMIC INSTABILITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; ONCOGENE; PLOIDY; PRIORITY JOURNAL; SYNCHRONOUS CARCINOMA;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CHI-SQUARE DISTRIBUTION; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; GENE AMPLIFICATION; GENOMIC INSTABILITY; GERMANY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASMS, MULTIPLE PRIMARY; ONCOGENES; PLOIDIES; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS;

EID: 79953305829     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2010.217     Document Type: Article

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