Dysregulation of β-Catenin is Common in Canine Sporadic Colorectal Tumors

Veterinary Pathology

Volumn 36, Issue 3, 1999, Pages 228-236

  McEntee, M F ^a,b   Brenneman, K A ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Adenomatous polyposis coli; Catenin; Dogs; E cadherin; Immunohistochemistry; Intestines; Neoplasms; P53

Indexed keywords

CANIS FAMILIARIS;

BETA CATENIN; CADHERIN; CYTOSKELETON PROTEIN; PROTEIN P53; TRANSACTIVATOR PROTEIN;

ADENOMA; ANIMAL; ANIMAL DISEASE; ARTICLE; CARCINOMA; COLON POLYPOSIS; COLORECTAL TUMOR; DOG; DOG DISEASE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; POLYP; SMALL INTESTINE; TUMOR SUPPRESSOR GENE;

ADENOMA; ADENOMATOUS POLYPOSIS COLI; ANIMALS; BETA CATENIN; CADHERINS; CARCINOMA; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; DOG DISEASES; DOGS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; IMMUNOHISTOCHEMISTRY; INTESTINE, SMALL; POLYPS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033128561     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.36-3-228     Document Type: Article

References (57)

1. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R: β-Catenin is a target for the ubiquitin-proteasome pathway. Eur Mol Biol Organ 16:3797-3804, 1997
2. Agarwal ML, Taylor WR, Chernov MV, Chernova OB, Stark GR: The p53 network. J Biol Chem 273:1-4, 1998
3. Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JK, Hamilton S, Vogelstein B: p53 Gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50:7717-7722, 1990
4. Bartek J, Bartkova J, Vojtesek B, Staskova Z, Lukas J, Rejthar A, Kovarik J, Midgley CA, Gannon JV, Lane DP: Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 6:1699-1703, 1991
5. Behrens J, Jerchow BA, Würtele M, Grimm J, Asbrand C, Wirtz R, Wedlich D, Birchmeier W: Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β. Science 280:596-599, 1998
6. Brannon M, Gomperts M, Sumoy L, Moon RT, Kimelman D: A β-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev 11:2359-2370, 1997
7. Cunningham J, Lust JA, Schaid DJ, Bren GD, Carpenter HA, Rizza E, Kovach JS, Thibodeau SN: Expression of p53 and 17p allelic loss in colorectal carcinoma. Cancer Res 52:1974-1980, 1992
8. Dorudi S, Sheffield JP, Poulsom R, Northover JM, Hart IR: E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol 142:981-986, 1993
9. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN: Upregulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107:1183-1188, 1994
10. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61:759-767, 1990
11. Foty RA, Steinberg MS: Measurement of tumor cell cohesion and suppression of invasion by E- or P-cadherin. Cancer Res 57:5033-5036, 1997
12. Gagliardi G, Kandemir O, Liu D, Guida M, Benvestito S, Ruers TG, Benjamin IS, Northover JM, Stamp GW, Talbot IC, Pignatelli M: Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Arch 426:149-154, 1995
13. Gamblin RM, Sagartz JE, Couto CG: Overexpression of p53 tumor suppressor protein in spontaneously arising neoplasms of dogs. Am J Vet Res 58:857-863, 1997
14. Hao X, Palazzo JP, Ilyas M, Tomlinson I, Talbot IC: Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. Anticancer Res 17:2241-2247, 1997
15. Hao X, Tomlinson I, Ilyas M, Palazzo JP, Talbot IC: Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumors. Virchows Arch 431:167-172, 1997
16. Hermiston ML, Gordon JI: Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270:1203-1207, 1995
17. Hermiston ML, Gordon JI: In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J Cell Biol 129: 489-506, 1995
18. Hiraguri S, Godfrey T, Nakamura H, Graff J, Collins C, Shayesteh L, Doggett N, Johnson K, Wheelock M, Herman J, Baylin S, Pinkel D, Gray J: Mechanisms of inactivation of E-cadherin in breast cancer cell lines. Cancer Res 58:1972-1977, 1998
19. Huber O, Korn R, McLaughlin J, Ohsugi M, Herrmann BG, Kemler R: Nuclear localization of β-catenin by interaction with transcription factor LEF-1. Mech Dev 59: 3-10, 1996
20. Ilyas M, Tomlinson IP, Hanby A, Talbot IC, Bodmer WF: Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers. Gut 40:654-659, 1997
21. Inomata M, Ochiai A, Akimoto S, Kitano S, Hirohashi S: Alteration of β-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients. Cancer Res 56:2213-2217, 1996
22. Keleti J, Quezado MM, Abaza MM, Raffeld M, Tsokos M: The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein. Am J Pathol 149:143-151, 1996
23. Kinzler KW, Vogelstein B: Lessons from hereditary colorectal cancer. Cell 87:159-170, 1996
24. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H: Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma. Science 275:1784-1787, 1997
25. Levy DB, Smith KJ, Beazer-Barclay Y, Hamilton SR, Vogelstein B, Kinzler KW: Inactivation of both APC alleles in human and mouse tumors. Cancer Res 54:5953-5958, 1994
26. Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y: Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1: 229-233, 1992
27. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW: Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275:1787-1790, 1997
28. Morin PJ, Vogelstein B, Kinzler KW: Apoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci USA 93:7950-7954, 1996
29. Munemitsu S, Albert I, Rubinfeld B, Polakis P: Deletion of an amino-terminal sequence stabilizes β-catenin in vivo and promotes hyperphoshorylation of the adenomatous polyposis coli tumor suppressor protein. Mol Cell Biol 16:4088-4094, 1996
30. Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P: Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 92:3046-3050, 1995
31. Muto T, Bussey HJ, Morson BC: The evolution of cancer of the colon and rectum. Cancer 36:2251-2270, 1975
32. Nathke IS, Adams CL, Polakis P, Sellin JH, Nelson WJ: The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol 134:165-179, 1996
33. Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW: Serine phosphorylation-regulated ubiquitination and degradation of β-catenin. J Biol Chem 272:24735-24738, 1997
34. Orsulic S, Peifer M: An in vivo structure-function study of armadillo, the β-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling. J Cell Biol 134: 1283-1300, 1996
35. Δ716 knockout mice. Cancer Res 57: 1644-1649, 1997
36. Porfiri E, Rubinfeld B, Albert I, Hovanes K, Waterman M, Polakis P: Induction of a β-catenin-LEF-1 complex by wnt-1 and transforming mutants of β-catenin. Oncogene 15:2833-2839, 1997
37. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW: APC mutations occur early during colorectal tumorigenesis. Nature 359:235-237, 1992
38. Pruneri G, Pignataro L, Carboni N, Luminari S, Capaccio P, Neri A, Buffa R: MDM-2 oncoprotein overexpression in laryngeal squamous cell carcinoma: association with wild-type p53 accumulation. Mod Pathol 10:785-792, 1997
39. Raftopoulos I, Davaris P, Karatzas G, Karayannacos P, Kouraklis G: Level of α-catenin expression in colorectal cancer correlates with invasiveness, metastatic potential, and survival. J Surg Oncol 68:92-99, 1998
40. Restucci B, Papparella S, De VG, Maiolino P: E-cadherin expression in normal and neoplastic canine mammary gland. J Comp Pathol 116:191-202, 1997
41. Rubinfeld B, Albert I, Porfiri E, Munemitsu S, Polakis P: Loss of β-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res 57: 4624-4630, 1997
42. Sagartz JE, Bodley WL, Gamblin RM, Couto CG, Tierney LA, Capen CC: p53 tumor suppressor protein overexpression in osteogenic tumors of dogs. Vet Pathol 33: 213-221, 1996
43. Sheng HM, Shao JY, Williams CS, Pereira MA, Taketo MM, Oshima M, Reynolds AB, Washington MK, DuBois RN, Beauchamp RD: Nuclear translocatin of β-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogen 19:543-549, 1998
44. Shiozaki H, Tahara H, Oka H, Miyata M, Kobayashi K, Tamura S, Iihara K, Doki Y, Hirano S, Takeichi M, Mori T: Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 139:17-23, 1991
45. Smith KJ, Johnson KA, Bryan TM, Hill DE, Markowitz S, Willson JK, Paraskeva C, Petersen GM. Hamilton SR, Vogelstein B, Kinzler KW: The APC gene product in normal and tumor cells. Proc Natl Acad Sci USA 90: 2846-2850, 1993
46. Smith KJ, Levy DB, Maupin P, Pollard TD, Vogelstein B, Kinzler KW: Wild-type but not mutant APC associates with the microtubule cytoskeleton. Cancer Res 54: 3672-3675, 1994
47. Sparks AB, Morin PJ, Vogelstein B, Kinzler KW: Mutational analysis of the APC/η-catenin/Tcf pathway in colorectal cancer. Cancer Res 58:1130-1134, 1998
48. Takeichi M: Cadherin cell adhesion receptors as a morphologic regulator. Science 251:1451-1455, 1991
49. 2-induced canine lung neoplasia. Vet Pathol 30:440, 1993 [Abstract]
50. Tominaga O, Hamelin R, Trouvat V, Salmon RJ, Lesec G, Thomas G, Remvikos Y: Frequently elevated content of immunochemically defined wild-type p53 protein in colorectal adenomas. Oncogene 8:2653-2658, 1993
51. Tsujii M, DuBois RN: Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493-501, 1995
52. Valerius KD, Powers BE, McPherron MA, Hutchison JM, Mann FA, Withrow SJ: Adenomatous polyps and carcinoma in situ of the canine colon and rectum: 34 cases (1982-1994). J Am Anim Hosp Assoc 33:156-160, 1997
53. Valizadeh A, Karayiannakis AJ, El-Hariry I, Kmiot W, Pignatelli M: Expression of E-cadherin-associated molecules (α-, β-, and γ-catenins and p120) in colorectal polyps. Am J Pathol 150:1977-1984, 1997
54. Williams CS, Luongo C, Radhika A, Zhang T, Lamps LW, Nanney LB, Beauchamp RD, DuBois RN: Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology 111:1134-1140, 1996
55. Wolf JC, Ginn PE, Homer B, Fox LE, Kurzman ID: Immunohistochemical detection of p53 tumor suppressor gene protein in canine eithelial colorectal tumors. Vet Pathol 34:394-404, 1997
56. 2-terminal truncated β-catenin on mouse intestinal epithelial homeostasis. J Cell Biol 141: 765-777, 1998
57. Yanagawa S, Lee JS, Haruna T, Oda H, Uemura T, Takeichi M, Ishimoto A: Accumulation of Armadillo induced by Wingless, Dishevelled, and dominant-negative Zeste-White 3 leads to elevated DE-cadherin in Drosophila clone 8 wing disc cells. J Biol Chem 272:25243-25251, 1997