Expression of E-cadherin, β-catenin and APC protein in canine colorectal tumours

Anticancer Research

Volumn 29, Issue 8, 2009, Pages 2919-2925

  Restucci, Brunella ^a   Martano, Manuela ^a   De Vico, Gionata ^a   Lo Muzio, Lorenzo ^b   Maiolino, Paola ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF FOGGIA   (Italy)

Author keywords

Adhesion molecules; APC; Colorectal tumours; Dog

Indexed keywords

APC PROTEIN; BETA CATENIN; CELL ADHESION MOLECULE; UVOMORULIN;

ANIMAL TISSUE; ARTICLE; BENIGN TUMOR; CELL PROLIFERATION; COLON ADENOMA; COLON MUCOSA; COLON POLYP; COLORECTAL TUMOR; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DOG; DYSPLASIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BETA CATENIN; CADHERINS; CELL ADHESION; CELL MEMBRANE; COLON; COLORECTAL NEOPLASMS; CYTOPLASM; DOGS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOENZYME TECHNIQUES; PROGNOSIS;

EID: 68549118795     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B and Kinzler KW: APC mutations occur early during colorectal tumorigenesis. Nature 359: 235-237, 1992.
2. Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S and Polakis P: Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272: 1023-1026, 1996. (Pubitemid 26259322)
3. Papkoff J, Rubinfeld B, Schryver B and Polakis P: Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. Mol Cell Biol 16: 2128-2134, 1996. (Pubitemid 26123733)
4. Bienz M and Clevers H: Linking colorectal cancer to Wnt signaling. Cell 103: 311-320, 2000.
5. Su LK, Vogelstein B and Kinzler KW: Association of the APC tumor suppressor protein with catenins. Science 262: 1734-1737, 1993. (Pubitemid 24030097)
6. -/- colon carcinoma. Science 275: 1784-1787, 1997. (Pubitemid 27136714)
7. Behrens J: Control of beta-catenin signaling in tumor development. Ann NY Acad Sci 910: 21-33; discussion 33-125, 2000.
8. Sormunen RT, Leong AS, Vaaraniemi JP, Fernando SS and Eskelinen SM: Immunolocalization of the fodrin, E-cadherin, and beta-catenin adhesion complex in infiltrating ductal carcinoma of the breast-comparison with an in vitro model. J Pathol 187: 416-423, 1999.
9. Abutaily AS, Collins JE and Roche WR: Cadherins, catenins and APC in pleural malignant mesothelioma. J Pathol 201: 355-362, 2003. (Pubitemid 37408255)
10. Sekine S, Sato S, Takata T, Fukuda Y, Ishida T, Kishino M, Shibata T, Kanai Y and Hirohashi S: Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas. Am J Pathol 163: 1707-1712, 2003. (Pubitemid 37310000)
11. McEntee MF, Chiu CH and Whelan J: Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. Carcinogenesis 20: 635-640, 1999.
12. Head KW, Cullen JM, Dubielzig RR, Else RW, Misdorp W, Patnaik AK, Tateyama S and van der Gaag I: Histological classification of the tumors of the alimentary system of domestic animals. In WHO International Hstological Classification of Tumors of Domestic Animals vol. X: FY S (ed.). Washington DC, AFIP, pp. 87-110, 2003.
13. Borzacchiello G, Ambrosio V, Galati P, Perillo A and Roperto F: Cyclooxygenase-1 and -2 expression in urothelial carcinomas of the urinary bladder in cows. Vet Pathol 40: 455-459, 2003. (Pubitemid 38406136)
14. Pignatelli M, Liu D, Nasim MM, Stamp GW, Hirano S and Takeichi M: Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells. Br J Cancer 66: 629-634, 1992.
15. Smith ME and Pignatelli M: The molecular histology of neoplasia: the role of the cadherin/catenin complex. Histopathology 31: 107-111, 1997.
16. Kirchner T and Brabletz T: Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation. Am J Pathol 157: 1113-1121, 2000. (Pubitemid 30757933)
17. Vleminckx K, Vakaet L Jr, Mareel M, Fiers W and van Roy F: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66: 107-119, 1991. (Pubitemid 121001351)
18. Hao X, Palazzo JP, Ilyas M, Tomlinson I and Talbot IC: Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. Anticancer Res 17: 2241-2247, 1997. (Pubitemid 27320976)
19. McEntee MF and Brenneman KA: Dysregulation of beta-catenin is common in canine sporadic colorectal tumors. Vet Pathol 36: 228-236, 1999.
20. Hulsken J, Birchmeier W and Behrens J: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol 127: 2061-2069, 1994.
21. Dorudi S, Sheffield JP, Poulsom R, Northover JM and Hart IR: E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol 142: 981-986, 1993. (Pubitemid 24060573)
22. Ilyas M and Tomlinson IP: The interactions of APC, E-cadherin and beta-catenin in tumour development and progression. J Pathol 182: 128-137, 1997. (Pubitemid 27287832)