Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 1, 2013, Pages 333-347

  Tarleton, Mark ^a   Dyson, Lauren ^a   Gilbert, Jayne ^b   Sakoff, Jennette A ^b   McCluskey, Adam ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b CALVARY MATER NEWCASTLE HOSPITAL   (Australia)

Author keywords

Acrylamides; Cytotoxicity; Focused library; Synthesis

Indexed keywords

2 (1H INDOLE 3 CARBONYL) 3 (3,4 DICHLOROPHENYL)ACRYLONITRILE; 2 (1H INDOLE 3 CARBONYL) 3 (4 (TRIFLUOROMETHYL)PHENYL)ACRYLONITRILE; 2 (1H INDOLE 3 CARBONYL) 3 (4 METHOXYPHENYL)ACRYLONITRILE; 2 (1H INDOLE 3 CARBONYL) 3 (4 NITROPHENYL)ACRYLONITRILE; 2 (1H INDOLE 3 CARBONYL) 3 (NAPHTHALEN 2 YL)ACRYLONITRILE; 2 (1H INDOLE 3 CARBONYL) 3 (PERFLUOROPHENYL)ACRYLONITRILE; 2 (1H INDOLE 3 CARBONYL) 3 4 TOLYLACRYLONITRILE; 2 (1H PYRROLE 2 CARBONYL) 3 (4 (TRIFLUOROMETHYL)PHENYL)ACRYLONITRILE; 2 (1H PYRROLE 2 CARBONYL) 3 4 TOLYLACRYLONITRILE; 2 CYANO 3 (5 (HYDROXYMETHYL)FURAN 2 YL) N (4 METHOXYBENZYL)ACRYLAMIDE; 2 CYANO 3 (FURAN 2 YL) N (4 METHOXYBENZYL)ACRYLAMIDE; 2 CYANO N (3,4 DICHLOROBENZYL) 3 (1H PYRROL 2 YL)ACRYLAMIDE; 2 CYANO N (4 METHOXYBENZYL) 3 (1H PYRROL 2 YL)ACRYLAMIDE; 2 CYANO N (4 METHOXYBENZYL) 3 (5 METHYLFURAN 2 YL)ACRYLAMIDE; 2 CYNO N (3,4 DICHLOROBENZYL) 3 (FURAN 2 YL)ACRYLAMIDE; 2 PHENYLACRYLAMIDE DERIVATIVE; 3 (1H INDOL 3 YL) 2 (1H PYRROLE 2 CARBONYL)ACRYLONITRILE; 3 (3,4 DICHLOROPHENYL) 2 (1H PYRROLE 2 CARBONYL)ACRYLONITRILE; 3 (4 CHLOROPHENYL) 2 (1H INDOLE 3 CARBONYL)ACRYLONITRILE; 3 (4 CHLOROPHENYL) 2 (1H PYRROLE 2 CARBONYL)ACRYLONITRILE; 3 (4 HYDROXYPHENYL) 2 (1H INDOLE 3 CARBONYL)ACRYLONITRILE; 3 (4 HYDROXYPHENYL) 2 (1H PYRROLE 2 CARBONYL)ACRYLONITRILE; 3 (4 METHOXYPHENYL) 2 (1H PYRROLE 2 CARBONYL)ACRYLONITRILE; 3 (4 NITROPHENYL) 2 (1H PYRROLE 2 CARBONYL)ACRYLONITRILE; 3 (5 BROMOFURAN 2 YL) 2 CYANO N (4 METHOXYBENZYL)ACRYLAMIDE; 3 (5 CHLOROFURAN 2 YL) 2 CYANO N (4 METHOXYBENZYL)ACRYLAMIDE; 3 (NAPHTHALEN 2 YL) 2 (1H PYRROLE 2 CARBONYL)ACRYLONITRILE; 3 (PENTAFLUOROPHENYL) 2 (1H PYRROLE 2 CARBONYL)ACRYLONITRILE; CYTOTOXIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; ASTROCYTOMA; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; COLON CARCINOMA; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GLIOBLASTOMA; HUMAN; HUMAN CELL; LUNG CARCINOMA; MALIGNANT NEOPLASTIC DISEASE; NEUROBLASTOMA; OVARY CARCINOMA; PANCREAS CARCINOMA; PHARMACOPHORE; PROSTATE CARCINOMA; PROTON NUCLEAR MAGNETIC RESONANCE; SKIN CARCINOMA; STRUCTURE ACTIVITY RELATION;

ACRYLAMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOTOXINS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870886448     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.10.003     Document Type: Article

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