Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3392-3397

  Hill, Timothy A ^a   Stewart, Scott G ^a   Sauer, Benjamin ^a   Gilbert, Jayne ^b   Ackland, Stephen P ^b   Sakoff, Jennette A ^b   McCluskey, Adam ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b NEWCASTLE MATER HOSPITAL   (Australia)

Author keywords

Anti cancer; Cantharidin; Norcantharidin; PP1; PP2A; Small molecule protein phosphatase inhibitors

Indexed keywords

CANTHARIDIN; HETEROCYCLIC COMPOUND; NORCANTHARIDIN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; THIOMORPHOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL MODIFICATION; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; NEUROBLASTOMA; OVARY CANCER; PROSTATE CANCER; PROTEIN FOLDING; SKIN CANCER;

ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CANTHARIDIN; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; PHOSPHOPROTEIN PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 34249330669     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.093     Document Type: Article

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