Thymidylate synthase inhibition induces S-phase arrest, biphasic mitochondrial alterations and caspase-dependent apoptosis in leukaemia cells

Cancer Chemotherapy and Pharmacology

Volumn 46, Issue 6, 2000, Pages 477-487

  Sakoff, J A ^a   Ackland, S P ^a  

^a NEWCASTLE MATER HOSPITAL   (Australia)

Author keywords

Anticancer agents; Antimetabolite; Caspases; Mitochondrial membrane potential

Indexed keywords

BONGKREKIC ACID; CASPASE; CASPASE INHIBITOR; CYCLOSPORIN A; NOLATREXED; THYMIDYLATE SYNTHASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; LEUKEMIA CELL; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0033661728     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800000164     Document Type: Article

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