-
1
-
-
0025325071
-
Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine)
-
Hertel, L. W., Boder, G. B., Kroin, J. S., Rinzel, S. M., Poore, G. A., Todd, G. C , and Grindey, G. B. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine). Cancer Res., 50. 4417-4422, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 4417-4422
-
-
Hertel, L.W.1
Boder, G.B.2
Kroin, J.S.3
Rinzel, S.M.4
Poore, G.A.5
Todd, G.C.6
Grindey, G.B.7
-
2
-
-
0025977171
-
Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (gemcitabine) against head and neck cancer
-
Braakhuis, B. J. M., van Dongen, G. A. M. S., Vermorken, J. B., and Snow, G. B. Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (gemcitabine) against head and neck cancer. Cancer Res., 51: 211-214, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 211-214
-
-
Braakhuis, B.J.M.1
Van Dongen, G.A.M.S.2
Vermorken, J.B.3
Snow, G.B.4
-
3
-
-
0027263596
-
The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer
-
Boven, E., Schipper, H., Erkelens, C. A. M., Hatty, S. A., and Pinedo, H. M. The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer. Br. J. Cancer. 68: 52-56, 1993.
-
(1993)
Br. J. Cancer.
, vol.68
, pp. 52-56
-
-
Boven, E.1
Schipper, H.2
Erkelens, C.A.M.3
Hatty, S.A.4
Pinedo, H.M.5
-
4
-
-
0028022127
-
Gemcitabine: Current status of Phase I and II trials
-
Kaye, S. B. Gemcitabine: current status of Phase I and II trials. J. Clin. Oncol., 12: 1527-1531, 1994.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 1527-1531
-
-
Kaye, S.B.1
-
5
-
-
0027993707
-
Efficacy and safety profile of gemcitabine in non-small cell lung cancer. Phase II study
-
Abratt, R. P., Rezwoda, W., Falkson, G., Goedhals, L., and Hacking, D. Efficacy and safety profile of gemcitabine in non-small cell lung cancer. Phase II study. J. Clin. Oncol., 12: 1535-1540, 1994.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 1535-1540
-
-
Abratt, R.P.1
Rezwoda, W.2
Falkson, G.3
Goedhals, L.4
Hacking, D.5
-
6
-
-
0028020890
-
Phase II study of gemcitabine (2′,2′-difluorodeoxycytidine) in previously treated ovarian cancer patients
-
Lund, B., Hansen, O. P., Theilade, K., Hansen, M., and Neijt, J. P. Phase II study of gemcitabine (2′,2′-difluorodeoxycytidine) in previously treated ovarian cancer patients. J. Natl. Cancer Inst., 86: 1530-1533, 1994.
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 1530-1533
-
-
Lund, B.1
Hansen, O.P.2
Theilade, K.3
Hansen, M.4
Neijt, J.P.5
-
7
-
-
0023783698
-
Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine
-
Heinemann, V., Hertel, L. W., Grindey, G. B., and Plunkett, W. Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine. Cancer Res., 48: 4024-4031, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 4024-4031
-
-
Heinemann, V.1
Hertel, L.W.2
Grindey, G.B.3
Plunkett, W.4
-
8
-
-
0027180521
-
2′,2′-difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA from tumour cell lines
-
Ruiz van Haperen, V. W. T., Veerman, G., Vermerken, J. B., and Peters, G. J. 2′,2′-difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA from tumour cell lines. Biochem. Pharmacol., 46: 762-766, 1993.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 762-766
-
-
Ruiz Van Haperen, V.W.T.1
Veerman, G.2
Vermerken, J.B.3
Peters, G.J.4
-
9
-
-
0026324313
-
Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
-
Huang, P., Chubb, S., Hertel, L. W., Grindey, G. B., and Plunkett, W. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res., 51: 6110-6117, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 6110-6117
-
-
Huang, P.1
Chubb, S.2
Hertel, L.W.3
Grindey, G.B.4
Plunkett, W.5
-
10
-
-
0025774461
-
Introduction: Cisplatin update
-
Muggia, F. Introduction: cisplatin update. Semin. Oncol., 18 (Suppl. 3): 1-4, 1991.
-
(1991)
Semin. Oncol.
, vol.18
, Issue.3 SUPPL.
, pp. 1-4
-
-
Muggia, F.1
-
12
-
-
0021894582
-
Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: Formation, identification and quantitation
-
Fichtinger-Schepman, A. M. J., Van der Veer, J. L., Den Hartog, J. H. J., Lohman, P. H. M., and Reedijk J. Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification and quantitation. Biochemistry, 24: 707-713, 1985.
-
(1985)
Biochemistry
, vol.24
, pp. 707-713
-
-
Fichtinger-Schepman, A.M.J.1
Van Der Veer, J.L.2
Den Hartog, J.H.J.3
Lohman, P.H.M.4
Reedijk, J.5
-
13
-
-
0004959064
-
Variability in DNA-adduct levels after in vivo treatment with the antitumor drug cisplatin
-
Fichtinger-Schepman, A. M. J. Variability in DNA-adduct levels after in vivo treatment with the antitumor drug cisplatin. J. Inorg. Biochem , 39: 154-58, 1989.
-
(1989)
J. Inorg. Biochem
, vol.39
, pp. 154-158
-
-
Fichtinger-Schepman, A.M.J.1
-
14
-
-
0025363447
-
Correlation between cell killing by cis-diamminedichloroplatinum(II) in six mammalian cell lines and binding of a cis-diamminedichloroplatinum(II)-DNA antiserum
-
Terheggen, P. M. A. B., Emondt, J. Y., Floot, B. G. J., Dijkman, R., Schrier, P. I., Den Engelse, L., and Begg A. C. Correlation between cell killing by cis-diamminedichloroplatinum(II) in six mammalian cell lines and binding of a cis-diamminedichloroplatinum(II)-DNA antiserum. Cancer Rev., 50. 3556-3561, 1990.
-
(1990)
Cancer Rev.
, vol.50
, pp. 3556-3561
-
-
Terheggen, P.M.A.B.1
Emondt, J.Y.2
Floot, B.G.J.3
Dijkman, R.4
Schrier, P.I.5
Den Engelse, L.6
Begg, A.C.7
-
15
-
-
0025972555
-
Formation of interaction products of carboplatin with DNA in vitro and in cancer patients
-
Terheggen, P. M. A. B., Begg, A. C., Emondt, J. Y., Dubbelman, R., Floot, B. G. J., and den Engelse L. Formation of interaction products of carboplatin with DNA in vitro and in cancer patients. Br. J. Cancer, 63: 195-200, 1991
-
(1991)
Br. J. Cancer
, vol.63
, pp. 195-200
-
-
Terheggen, P.M.A.B.1
Begg, A.C.2
Emondt, J.Y.3
Dubbelman, R.4
Floot, B.G.J.5
Den Engelse, L.6
-
16
-
-
0025799467
-
Platinum DNA-damage in leucocyte DNA of patients receiving cisplatin and carboplatin chemotherapy, measured by atomic absorption spectrometry
-
Lond.
-
Parker, R. J., Gill, I., Tarone, R., Vionnet, J., Grunberg, S., Muggia, F., and Reed E. Platinum DNA-damage in leucocyte DNA of patients receiving cisplatin and carboplatin chemotherapy, measured by atomic absorption spectrometry. Carcinogenesis (Lond.), 12: 1253-1258, 1991.
-
(1991)
Carcinogenesis
, vol.12
, pp. 1253-1258
-
-
Parker, R.J.1
Gill, I.2
Tarone, R.3
Vionnet, J.4
Grunberg, S.5
Muggia, F.6
Reed, E.7
-
17
-
-
0000714484
-
Platinum DNA-damage in leucocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy
-
Reed, E., Ozols, R. F., Tarone, R., Yuspa, S. H., and Poirier, M. C. Platinum DNA-damage in leucocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy. Proc. Natl. Acad. Sci. USA, 84: 5024-5028, 1987.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 5024-5028
-
-
Reed, E.1
Ozols, R.F.2
Tarone, R.3
Yuspa, S.H.4
Poirier, M.C.5
-
18
-
-
0025322746
-
Biophysical studies of the modification of DNA by antitumour platinum coordination complexes
-
Brabec, V., Kleinwachter, V., Butour, J. L., and Johnson, N. P. Biophysical studies of the modification of DNA by antitumour platinum coordination complexes. Biophys. Chem., 35: 129-141, 1990.
-
(1990)
Biophys. Chem.
, vol.35
, pp. 129-141
-
-
Brabec, V.1
Kleinwachter, V.2
Butour, J.L.3
Johnson, N.P.4
-
19
-
-
0026598056
-
Studies on the mechanism of the synergistic interaction between 2′-deoxy-5-azacytidine and CDDP
-
Abbruzzese, J. L., and Frost, P. Studies on the mechanism of the synergistic interaction between 2′-deoxy-5-azacytidine and CDDP. Cancer Chemother. Pharmacol., 30: 31-36, 1982.
-
(1982)
Cancer Chemother. Pharmacol.
, vol.30
, pp. 31-36
-
-
Abbruzzese, J.L.1
Frost, P.2
-
20
-
-
0023238952
-
Interactions of cis-diamminedichloroplatinum(II) with 1-β-D-arabinofuranosylcytosine in LoVo colon carcinoma cells
-
Fram, R. J., Robichaud, N., Bishov, S. D., and Wilson, J. M. Interactions of cis-diamminedichloroplatinum(II) with 1-β-D-arabinofuranosylcytosine in LoVo colon carcinoma cells. Cancer Res., 47: 3360-3365, 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 3360-3365
-
-
Fram, R.J.1
Robichaud, N.2
Bishov, S.D.3
Wilson, J.M.4
-
21
-
-
0024413284
-
Stereoselective, strong inhibition of ribonucleotide reduciase from E Coli by cisplatin
-
Smith, S. L., and Douglas, K. T. Stereoselective, strong inhibition of ribonucleotide reduciase from E Coli by cisplatin. Biochem. Biophys. Res. Commun., 162: 715-723, 1989.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.162
, pp. 715-723
-
-
Smith, S.L.1
Douglas, K.T.2
-
22
-
-
0023938053
-
Biochemical and molecular properties of cisplatin-resistant A2780 cells grown in folinic acid
-
Lu, Y., Han, J., and Scanlon, K. J. Biochemical and molecular properties of cisplatin-resistant A2780 cells grown in folinic acid. J. Biol. Chem., 263: 4891-4894, 1988.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 4891-4894
-
-
Lu, Y.1
Han, J.2
Scanlon, K.J.3
-
23
-
-
0028067217
-
Development and characterization of a 2′,2′-difiuorodeoxycytidine-resistant variant of the human ovarian cancer cell line A2780
-
Ruiz van Haperen, V. W. T., Veerman, G., Eriksson, S., Boven, E., Stegmann, A. P. A., Hermsen, M., Vermorken, J B , Pinedo, H. M., and Peters, G. J. Development and characterization of a 2′,2′-difiuorodeoxycytidine-resistant variant of the human ovarian cancer cell line A2780. Cancer Res., 54: 4138-4143, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 4138-4143
-
-
Ruiz Van Haperen, V.W.T.1
Veerman, G.2
Eriksson, S.3
Boven, E.4
Stegmann, A.P.A.5
Hermsen, M.6
Vermorken, J.B.7
Pinedo, H.M.8
Peters, G.J.9
-
24
-
-
0002236501
-
Establishment of epidermoid carcinoma cell lines
-
R. E. Wines (ed.) New York: John Wiley & Sons
-
Carey, T. E. Establishment of epidermoid carcinoma cell lines. In: R. E. Wines (ed.) Head and Neck Cancer, pp. 287-314. New York: John Wiley & Sons, 1985.
-
(1985)
Head and Neck Cancer
, pp. 287-314
-
-
Carey, T.E.1
-
25
-
-
0026547072
-
In vitro and in vivo studies on the combination of brequinar sodium (DUP 785, NSC 368390) with 5-fluorouracil, effects of uridine
-
Peters, G. J., Kraal, I., and Pinedo, H. M. In vitro and in vivo studies on the combination of brequinar sodium (DUP 785, NSC 368390) with 5-fluorouracil, effects of uridine. Br. J. Cancer, 65: 229-233, 1992.
-
(1992)
Br. J. Cancer
, vol.65
, pp. 229-233
-
-
Peters, G.J.1
Kraal, I.2
Pinedo, H.M.3
-
26
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer drug screening
-
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R. New colorimetric cytotoxicity assay for anticancer drug screening. J. Natl. Cancer Inst., 82: 1107-1112, 1990.
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
27
-
-
0025878872
-
Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing
-
Keepers, Y. P., Pizao, P. E., Peters, G. J., Van Ark-Otte, J., Winograd, B., and Pinedo, H. M. Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing. Eur. J. Cancer, 27: 897-900, 1991.
-
(1991)
Eur. J. Cancer
, vol.27
, pp. 897-900
-
-
Keepers, Y.P.1
Pizao, P.E.2
Peters, G.J.3
Van Ark-Otte, J.4
Winograd, B.5
Pinedo, H.M.6
-
28
-
-
0027287554
-
Transformation of mouse fibroblasts with the oncogenes H-ray or trk is associated with pronounced changes in drug sensitivity and metabolism
-
Peters, G. J., Wets, M., Keepers, Y. P. A. M., Oskam, R., Van Ark-One, J., Noordhuis, P., Smid, K., and Pinedo, H. M. Transformation of mouse fibroblasts with the oncogenes H-ray or trk is associated with pronounced changes in drug sensitivity and metabolism. Int. J. Cancer, 54: 450-455, 1993
-
(1993)
Int. J. Cancer
, vol.54
, pp. 450-455
-
-
Peters, G.J.1
Wets, M.2
Keepers, Y.P.A.M.3
Oskam, R.4
Van Ark-One, J.5
Noordhuis, P.6
Smid, K.7
Pinedo, H.M.8
-
29
-
-
0021118703
-
Quantitative analysis of dose-effect relationship: The combined effects of multiple drugs on enzyme inhibitors
-
G. Weber (ed.) New York: Pergamon Press
-
Chou, T. C., Talalay P. Quantitative analysis of dose-effect relationship: the combined effects of multiple drugs on enzyme inhibitors. In: G. Weber (ed.) Advances in Enzyme Regulation, pp. 27-55. New York: Pergamon Press, 1983.
-
(1983)
Advances in Enzyme Regulation
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
30
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco, W. R., Bravo, G., and Parsons, J. C. The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev., 47: 331-385, 1995.
-
(1995)
Pharmacol. Rev.
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
31
-
-
0018425119
-
Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
-
Steel, G. G., and Peckham, M. J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Im. J. Radiat. Oncol. Biol. Phys., 5: 85-91, 1979.
-
(1979)
Im. J. Radiat. Oncol. Biol. Phys.
, vol.5
, pp. 85-91
-
-
Steel, G.G.1
Peckham, M.J.2
-
32
-
-
0028105119
-
Schedule dependence of sensitivity to 2′,2′-difluorodeoxycytidine (gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumor cell lines and solid tumors
-
Ruiz van Haperen, V. W. T., Veerman, G., Boven, E., Noordhuis, P., Vermorken, J. B., and Peters G. J. Schedule dependence of sensitivity to 2′,2′-difluorodeoxycytidine (gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumor cell lines and solid tumors. Biochem. Pharmacol., 48: 1327-1339, 1994.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 1327-1339
-
-
Ruiz Van Haperen, V.W.T.1
Veerman, G.2
Boven, E.3
Noordhuis, P.4
Vermorken, J.B.5
Peters, G.J.6
-
33
-
-
0019476174
-
Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation
-
Birnboim, H. C., and Jevcak, J. J. Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Res., 41: 1889-1892, 1981.
-
(1981)
Cancer Res.
, vol.41
, pp. 1889-1892
-
-
Birnboim, H.C.1
Jevcak, J.J.2
-
34
-
-
0023258905
-
Role of free radicals in an adriamycin-resistant human small cell lung cancer cell line
-
Meijer, C., Mulder, N. H., Timmer-Bosscha, H., Zijlstra, J. G., and De Vries, E. G. E. Role of free radicals in an adriamycin-resistant human small cell lung cancer cell line. Cancer Res., 47: 4613-4617, 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 4613-4617
-
-
Meijer, C.1
Mulder, N.H.2
Timmer-Bosscha, H.3
Zijlstra, J.G.4
De Vries, E.G.E.5
-
35
-
-
0027479992
-
2′-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation
-
Ellerhorst, J. A., Frost, P , Abbruzzese, J. L., Newman, R. A., and Chernajovsky, Y. 2′-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation. Br. J. Cancer, 67: 209-215, 1993.
-
(1993)
Br. J. Cancer
, vol.67
, pp. 209-215
-
-
Ellerhorst, J.A.1
Frost, P.2
Abbruzzese, J.L.3
Newman, R.A.4
Chernajovsky, Y.5
-
36
-
-
0025113618
-
Application to a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-β-D-arabinofuranosylcytosine
-
Greco, W R., Hyoung, S. P., and Rustum, Y. M. Application to a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-β-D-arabinofuranosylcytosine. Cancer Res., 50: 5318-5327, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 5318-5327
-
-
Greco, W.R.1
Hyoung, S.P.2
Rustum, Y.M.3
-
37
-
-
0004189468
-
Gemcitabine suppresses the repair of cisplatin adducts in plasmid DNA by extracts of cisplatin-resistant human colon carcinoma cells
-
Yang, L Y., Li, L., Liu, X M., Keating, M. J., and Plunkett, W. Gemcitabine suppresses the repair of cisplatin adducts in plasmid DNA by extracts of cisplatin-resistant human colon carcinoma cells. Proc. Am. Assoc. Cancer Res., 36: 357, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 357
-
-
Yang, L.Y.1
Li, L.2
Liu, X.M.3
Keating, M.J.4
Plunkett, W.5
-
38
-
-
0019379808
-
Synergistic lethal effect of cis-diamminedichloroplatinum and I-β-D-arabino furanosyl cytosine
-
Bergerat, J. P., Drewinko, B., Corry, P., Barlogie, B., and Ho, D. H. Synergistic lethal effect of cis-diamminedichloroplatinum and I-β-D-arabino furanosyl cytosine. Cancer Res., 41: 25-30, 1981.
-
(1981)
Cancer Res.
, vol.41
, pp. 25-30
-
-
Bergerat, J.P.1
Drewinko, B.2
Corry, P.3
Barlogie, B.4
Ho, D.H.5
-
39
-
-
0017872774
-
Caffeine enhancement of X-ray killing in cultured human and rodent cells
-
Waldren, C. A., and Rasko, I. Caffeine enhancement of X-ray killing in cultured human and rodent cells. Radiat Res., 73: 95-110, 1987.
-
(1987)
Radiat Res.
, vol.73
, pp. 95-110
-
-
Waldren, C.A.1
Rasko, I.2
-
40
-
-
84892372525
-
Mice, men, mustards and methylated xanthines: The potential role of caffeine and related drugs in the sensitization of human tumours to alkylating agents
-
Byfield, J. E. Mice, men, mustards and methylated xanthines: the potential role of caffeine and related drugs in the sensitization of human tumours to alkylating agents. Br. J. Cancer., 43: 667-683, 1981.
-
(1981)
Br. J. Cancer.
, vol.43
, pp. 667-683
-
-
Byfield, J.E.1
-
41
-
-
0028062981
-
Molecular effect of 2′,2′-difluorodeoxycytidine (Gemcitabine) on DNA replication in intact HL-60 cells
-
Ross, D. D., and Cuddy, D. P. Molecular effect of 2′,2′-difluorodeoxycytidine (Gemcitabine) on DNA replication in intact HL-60 cells. Biochem. Pharmacol , 48: 1619-1630, 1994.
-
(1994)
Biochem. Pharmacol
, vol.48
, pp. 1619-1630
-
-
Ross, D.D.1
Cuddy, D.P.2
-
42
-
-
0027267623
-
Amphibolic drug combinations: The design of selective antimetabolite protocols based upon the kinetic properties of multienzyme systems
-
Jackson, R. C. Amphibolic drug combinations: the design of selective antimetabolite protocols based upon the kinetic properties of multienzyme systems. Cancer Res., 53: 3998-4003, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 3998-4003
-
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Jackson, R.C.1
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