Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro

Acta Pharmacologica Sinica

Volumn 33, Issue 12, 2012, Pages 1542-1548

  Yang, Li Jing ^a   Chen, Yan ^a   He, Jing ^a   Yi, Sha ^a   Wen, Lu ^a   Zhao, Jie ^a   Zhang, Ben Ping ^a   Cui, Guo Hui ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Autophagic flux; Autophagy; Beclin 1; Betulinic acid; Caspase 3; LC3 II; Multiple myeloma; Rapamycin; Z DEVD FMK

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BECLIN 1; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BETULIC ACID; CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; PROPIDIUM IODIDE; PROTEIN P62; RAPAMYCIN;

APOPTOSIS; ARTICLE; AUTOPHAGIC FLUX; AUTOPHAGY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MULTIPLE MYELOMA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MULTIPLE MYELOMA; OLIGOPEPTIDES; TRITERPENES;

EID: 84870782845     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.102     Document Type: Article

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