Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1

Acta Pharmacologica Sinica

Volumn 33, Issue 1, 2012, Pages 91-100

  Zeng, Rong ^a   Chen, Yan ^a   Zhao, Shuai ^a   Cui, Guo Hui ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

apoptosis; autophagy; human multiple myeloma cells; oridonin; ROS; SIRT1

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BECLIN 1; CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; ORIDONIN; REACTIVE OXYGEN METABOLITE; SIRTUIN 1;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL ASSAY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MULTIPLE MYELOMA; MYELOMA CELL; NICK END LABELING; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES, KAURANE; HUMANS; MEMBRANE PROTEINS; MULTIPLE MYELOMA; REACTIVE OXYGEN SPECIES; SIRTUIN 1;

EID: 84855468411     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.143     Document Type: Article

References (32)

1. Ikezoe T, Chen SS, Tong XJ, Heber D, Taguchi H, Koeffer HP. Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells. Int J Oncol 2003; 23: 1187-93.
2. Osawa K, Yasuda H, Maruyama T, Morita H, Takeya K, Itokawa H. Antibacterial trichorabdal diterpenes from Rabdosia trichocarpa. Phytochemistry 1994; 36: 1287-91. (Pubitemid 2118500)
3. Han QB, Li ML, Li SH, Mou YK, Lin ZW, Sun HD. Ent-kaurane diterpenoids from Isodon rubescens var lushanensis. Chem Pharm Bull (Tokyo) 2003; 51: 790-3.
4. Bursch W, Ellinger A, Gerner C, Frohwein U, Schulte-Hermann R. Programmed cell death (PCD). Apoptosis, autophagic PCD, or others? Ann N Y Acad Sci 2000; 926: 1-12. (Pubitemid 32050138)
5. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306: 990-5. (Pubitemid 39482894)
6. Tsujimoto Y, Shimizu S. Another way to die: autophagic programmed cell death. Cell Death Differ 2005; 12: 1528-34. (Pubitemid 41553989)
7. Yang ZJ, Chee CE, Huang S, Sinicrope FA. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 2011; 10: 1533-41.
8. Cui Q, Tashiro S, Onodera S, Minami M, Ikejima T. Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation. J Pharmacol Sci 2007; 105: 317-25.
9. Li D, Cui Q, Chen SG, Wu LJ, Tashiro S, Onodera S, et al. Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells. J Pharmacol Sci 2007; 105: 22-33. (Pubitemid 47463521)
10. Cheng Y, Qiu F, Huang J, Tashiro S, Onodera S, Ikejima T. Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death. Arch Biochem Biophys 2008; 475: 148-55.
11. Hoang B, Benavides A, Shi Y, Frost P, Lichtenstein A. Effect of autophagy on multiple myeloma cell viability. Mol Cancer Ther 2009; 8: 1974-84.
12. Hou DX, Tong X, Terahara N, Luo D, Fujii M. Delphinidin 3-sam bu bio-side, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mito chondrial pathway. Arch Biochem Biophys 2005; 440: 101-9. (Pubitemid 41033349)
13. Chipuk JE, Bouchier-Hayes L, Green DR. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ 2006; 13: 1396-402. (Pubitemid 44057475)
14. Lisanti MP, Martinez-Outschoorn UE, Chiavarina B, Pavlides S, Whitaker-Menezes D, Tsirigos A, et al. Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxida tive stress and autophagy/mitophagy in the tumor micro-environment. Cancer Biol Ther 2010; 10: 537-42.
15. Essick EE, Sam F. Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. Oxid Med Cell Longev 2010; 3: 168-77.
16. Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 2011; 36: 30-8.
17. Grimsrud PA, Xie H, Griffin TJ, Bernlohr DA. Oxidative stress and covalent modifcation of protein with bioactive aldehydes. J Biol Chem 2008; 283: 21837-41.
18. Hasegawa K, Wakino S, Yoshioka K, Tatematsu S, Hara Y, Minakuchi H, et al. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochem Biophys Res Commun 2008; 372: 51-6.
19. Caito S, Hwang JW, Chung S, Yao H, Sundar IK, Rahman I. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity. Biochem Biophys Res Commun 2010; 392: 264-70.
20. Ford J, Jiang M, Milner J. Cancer-specifc functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res 2005; 65: 10457-63. (Pubitemid 41743740)
21. Kojima K, Ohhashi R, Fujita Y, Hamada N, Akao Y, Nozawa Y, et al. A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem Biophys Res Commun 2008; 373: 423-8.
22. Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, et al. Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys 2010; 500: 203-9.
23. Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I. Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys 2010; 501: 79-90.
24. Xie HY, Liang JG, Liu Y, Zhang ZL, Pang DW, He ZK, et al. Preparation and characterization of overcoated II-VI quantum dots. J Nanosci Nanotechnol 2005; 5: 880-6. (Pubitemid 41647848)
25. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720-8.
26. Cui Q, Tashiro S, Onodera S, Ikejima T. Augmentation of oridonin-induced apoptosis observed with reduced autophagy. J Pharmacol Sci 2006; 101: 230-9. (Pubitemid 44114317)
27. Jia L, Dourmashkin RR, Allen PD, Gray AB, Newland AC, Kelsey SM. Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br J Haematol 1997; 98: 673-85. (Pubitemid 27386551)
28. Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 2007; 170: 75-86. (Pubitemid 47339191)
29. Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 2008; 15: 171-82. (Pubitemid 350286185)
30. Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I. Sirtuin regulates cigarette smoke-induced proinfammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic infammation and aging. Am J Physiol Lung Cell Mol Physiol 2007; 292: L567-76.
31. Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an anti-infammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 177: 861-70. (Pubitemid 351600664)
32. Kim EJ, Um SJ. SIRT1: roles in aging and cancer. BMB Rep 2008; 41: 751-6.