The role of autophagy in anticancer therapy: Promises and uncertainties

Journal of Internal Medicine

Volumn 268, Issue 5, 2010, Pages 410-418

  Tschan, M P ^a   Simon, H U ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

ATG; Autophagy; Cancer; Therapy; Tumourigenesis

Indexed keywords

ANTINEOPLASTIC AGENT; AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 5; BECLIN 1; CHLOROQUINE; DASATINIB; EVEROLIMUS; FAS ASSOCIATED DEATH DOMAIN PROTEIN; HISTONE DEACETYLASE INHIBITOR; IMATINIB; INTERLEUKIN 24; NILOTINIB; PEPTIDES AND PROTEINS; PROTEIN P53; PROTEIN TYROSINE KINASE INHIBITOR; SIRTUIN 1; UNCLASSIFIED DRUG;

APOPTOSIS; AUTOPHAGY; BREAST CELL; CANCER CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; CONFERENCE PAPER; DOWN REGULATION; GENOMIC INSTABILITY; HUMAN; LEUKEMIA CELL; LONGEVITY; MALARIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77958524723     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2010.02266.x     Document Type: Conference Paper

References (59)

1. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-75.
2. Kroemer G, Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008; 9: 1004-10.
3. Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23: 2891-906.
4. Eskelinen EL. New insights into the mechanisms of macroautophagy in mammalian cells. Int Rev Cell Mol Biol 2008; 266: 207-47.
5. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6: 463-77.
6. Mizushima N. Autophagy: process and function. Genes Dev 2007; 21: 2861-73.
7. Dikic I, Johansen T, Kirkin V. Selective autophagy in cancer development and therapy. Cancer Res 2010; 70: 3431-4.
8. Zhong Y, Wang QJ, Li X et al. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 2009; 11: 468-76.
9. Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 2008; 90: 313-23.
10. Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9: 1102-9.
11. Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 2004; 36: 2503-18.
12. Weidberg H, Shvets E, Shpilka T, Shimron F, Shinder V, Elazar Z. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBOJ 2010; 29: 1792-802.
13. Mathew R, Karp CM, Beaudoin B et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137: 1062-75.
14. Liang XH, Jackson S, Seaman M et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672-6.
15. Qu X, Yu J, Bhagat G et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112: 1809-20.
16. Kim MS, Jeong EG, Ahn CH, Kim SS, Lee SH, Yoo NJ. Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability. Hum Pathol 2008; 39: 1059-63.
17. Liang C, Feng P, Ku B et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8: 688-99.
18. Hoyer-Hansen M, Jaattela M. Autophagy: an emerging target for cancer therapy. Autophagy 2008; 4: 574-80.
19. Hsu KF, Wu CL, Huang SC et al. Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells. Autophagy 2009; 5: 451-60.
20. Yokoyama T, Miyazawa K, Naito M et al. Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells. Autophagy 2008; 4: 629-40.
21. Pyo JO, Jang MH, Kwon YK et al. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005; 280: 20722-9.
22. Yousefi S, Perozzo R, Schmid I et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 2006; 8: 1124-32.
23. Pattingre S, Tassa A, Qu X et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-39.
24. Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 2009; 16: 966-75.
25. Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008; 4: 600-6.
26. Saeki K, Yuo A, Okuma E et al. Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells. Cell Death Differ 2000; 7: 1263-9.
27. Tormo D, Checinska A, Alonso-Curbelo D et al. Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell 2009; 16: 103-14.
28. Moreau K, Luo S, Rubinsztein DC. Cytoprotective roles for autophagy. Curr Opin Cell Biol 2010; 22: 206-11.
29. Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5: 726-34.
30. Mishima Y, Terui Y, Taniyama A et al. Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors. Cancer Sci 2008; 99: 2200-8.
31. Bellodi C, Lidonnici MR, Hamilton A et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009; 119: 1109-23.
32. White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009; 15: 5308-16.
33. Lebedeva IV, Sauane M, Gopalkrishnan RV et al. mda-7/IL-24: exploiting cancer's Achilles' heel. Mol Ther 2005; 11: 4-18.
34. Sarkar D, Su ZZ, Lebedeva IV et al. mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci U S A 2002; 99: 10054-9.
35. Eager R, Harle L, Nemunaitis J. Ad-MDA-7; INGN 241: a review of preclinical and clinical experience. Expert Opin Biol Ther 2008; 8: 1633-43.
36. Bhutia SK, Dash R, Das SK et al. Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24. Cancer Res 2010; 70: 3667-76.
37. Chen N, Debnath J. Autophagy and tumorigenesis. FEBS Lett 2010; 584: 1427-35.
38. Yousefi S, Simon HU. Autophagy in cancer and chemotherapy. Results Probl Cell Differ 2009; 49: 183-90.
39. Lee IH, Cao L, Mostoslavsky R et al. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A 2008; 105: 3374-9.
40. Ghosh HS, McBurney M, Robbins PD. SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 2010; 5: e9199.
41. Brooks CL, Gu W. How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer 2009; 9: 123-8.
42. Napper AD, Hixon J, McDonagh T et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem 2005; 48: 8045-54.
43. Peck B, Chen CY, Ho KK et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther 2010; 9: 844-55.
44. Green DR, Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature 2009; 458: 1127-30.
45. Maiuri MC, Galluzzi L, Morselli E, Kepp O, Malik SA, Kroemer G. Autophagy regulation by p53. Curr Opin Cell Biol 2010; 22: 181-5.
46. Crighton D, Wilkinson S, O'Prey J et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126: 121-34.
47. Mauvezin C, Orpinell M, Francis VA et al. The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells. EMBO Rep 2010; 11: 37-44.
48. Nowak J, Archange C, Tardivel-Lacombe J et al. The TP53INP2 protein is required for autophagy in mammalian cells. Mol Biol Cell 2009; 20: 870-81.
49. Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9: 563-75.
50. Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008; 134: 451-60.
51. Wang W, Guan KL. AMP-activated protein kinase and cancer. Acta Physiol (Oxf) 2009; 196: 55-63.
52. Sherr CJ. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2001; 2: 731-7.
53. Reef S, Zalckvar E, Shifman O et al. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell 2006; 22: 463-75.
54. Pimkina J, Humbey O, Zilfou JT, Jarnik M, Murphy ME. ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem 2009; 284: 2803-10.
55. Raveh T, Droguett G, Horwitz MS, DePinho RA, Kimchi A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol 2001; 3: 1-7.
56. Harrison B, Kraus M, Burch L et al. DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. J Biol Chem 2008; 283: 9999-10014.
57. Zalckvar E, Berissi H, Mizrachy L et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 2009; 10: 285-92.
58. Michie AM, McCaig AM, Nakagawa R, Vukovic M. Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer. FEBS J 2010; 277: 74-80.
59. Van Leeuwen I, Lain S. Sirtuins and p53. Adv Cancer Res 2009; 102: 171-95.