Peltophorum Africanum, a traditional South African medicinal plant, contains n anti HIV-1 constituent, betulinic acid

Tohoku Journal of Experimental Medicine

Volumn 217, Issue 2, 2009, Pages 93-99

  Theo, Andros ^a   Masebe, Tracy ^b   Suzuki, Yasuhiro ^a   Kikuchi, Haruhisa ^a   Wada, Shoko ^a   Obi, Chikwelu Larry ^c   Bessong, Pascal Obong ^b   Usuzawa, Motoki ^a,d   Oshima, Yoshiteru ^a   Hattori, Toshio ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b UNIVERSITY OF VENDA   (South Africa)

^c WALTER SISULU UNIVERSITY   (South Africa)

^d The Japan Foundation   (Japan)

Author keywords

Extracts; HIV 1; MAGI CCR5+ cells; Medicinal plants; South Africa

Indexed keywords

ACETIC ACID ETHYL ESTER; BERGENIN; BETA GALACTOSIDASE; BETULIC ACID; BUTANOL; CATECHIN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; FLAVONOID; GLYCYRRHIZIC ACID; METHANOL; PELTOPHORUM AFRICANUM EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; WATER; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; TRITERPENE;

ANTIGEN EXPRESSION; ANTIVIRAL ACTIVITY; ARTICLE; BARK; BIOASSAY; BIODIVERSITY; CONTROLLED STUDY; DRUG RESEARCH; DRUG STRUCTURE; ETHNOBOTANY; FRACTIONATION; GEL CHROMATOGRAPHY; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LEGUME; LONG TERMINAL REPEAT; MEDICINAL PLANT; PELTOPHORUM AFRICANUM; SOUTH AFRICA; TRADITIONAL MEDICINE; VIRUS INHIBITION; AFRICAN MEDICINE; CELL DEATH; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION; PHYTOTHERAPY;

ANTI-HIV AGENTS; CELL DEATH; FABACEAE; HELA CELLS; HIV-1; HUMANS; MEDICINE, AFRICAN TRADITIONAL; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; SOUTH AFRICA; TRITERPENES;

EID: 66949114722     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.217.93     Document Type: Article

References (38)

1. Adachi, A., Gendelman, H.E., Koenig, S., Folks, T., Willey, R., Rabson, A. & Martin, M.A. (1986) Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol., 59, 284-291.
2. Aiken, C. & Chen, C.H. (2005) Betulinic acid derivatives as HIV-1 antivirals. Trends Mol. Med., 11, 31-36.
3. Baba, M., Konno, K., Shigeta, S. & De Clercq, E. (1987) In vitro activity of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl) adenine against newly isolated clinical varicella-zoster virus strains. Eur. J. Clin. Microbiol., 6, 158-160.
4. Barre-Sinoussi, F., Chermann, J.C., Rey, F., Nugeyre, M.T., Chamaret, S., Gruest, C., Dauguest, C., Axler-blin, C., Vézinet-Brun, F., Rouzioux, C., Rozenbaum, W. & Montagnier, L. (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science, 220, 868-871.
5. Bessong, P.O. & Obi, C.L. (2006) Ethnopharmacology of human immunodeficiency virus in South Africa- a minireview. Afr. J. Biotech., 5, 1693-1699.
6. Bessong, P.O., Obi, C.L., Andreola, M., Rojas L.B., Pouysegu, L., Igumbor, E., Meyer, J.J.M., Quideau, S. & Litvak, S. (2005) Evaluation of selected South African medicinal plants for inhibitory properties against human immunodeficiency virus type 1 reverse transcriptase and integrase. J. Ethnopharmacol., 99, 83-91.
7. Bessong, P.O., Obi, C.L., Igumbor, E., Andreola, M. & Litvak, S. (2004) In vitro activity of three South African medicinal plants against human immunodeficiency virus type 1 reverse transcriptase. Afr. J. Biotechnol., 3, 555-559.
8. Chackerian, B., Long, E.M., Luciw, P.A. & Overbaugh, J. (1997) Human immunodeficiency virus type 1 co-receptors participates in post entry stages of the virus replication cycle and function in SIV infection. J. Virol., 71, 3932-3939.
9. De Clercq, E. (2000) Current lead natural products for the chemotherapy of human immuno deficiency virus infection. Med. Res. Rev., 20, 323-349.
10. Felgner, J.H., Kumar, R., Sridhar, C.N., Wheeler, C.J., Tsai, J.Y., Border, R., Ramsey, P., Martin, M. & Feigner, L.P. (1993) Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem., 269, 2550-2561.
11. Flosh, V., Audrezet, M.P., Guillaume, C., Gobin, E., Bolch, Le.G., Clement, J.C., Yaouanc, J.J., Abbayes, Des.H., Mercier, B., Leroy, J.P., Abgrall, J.F. & Ferec, C. (1998) Transgene expression kinetics after transfection with cationic phosphonolipids in hematopoietic non adherent cells. Biochim. Biophys. Acta., 1371, 53-70.
12. Francois, C. & Hance, A.J. (2004) HIV drug resistance. N. Engl. J. Med., 350, 1023-1035.
13. Fujioka, T. & Kashiwada, Y. (1994) Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J. Nat. Prod., 57, 243-247.
14. Gallo, R.C., Sarin, P.S., Gelmann, E.P., Robert-Guroff, M., Richardson, E., Kalyanaraman, V.S., Mann, D., Sidhu, G.D., Stahl, R.E., Zolla-Pazner, S., Leibowitch, J. & Popovic, M. (1983) Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science, 220, 865-867.
15. Gulick, R.M., Mellors, J.W., Havlir, D., Eron, J.J., Gonzalez, C., Mcmahon, D., Richman, D.D., Valentine, F.T., Jonas, L., Meibohm, A., Emini, E.A. & Chodakewitz, J.A. (1997) Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N. Engl. J. Med., 337, 734-739.
16. Hamouda, C., Amamou, M., Thabet, H., Yacoub, M., Hedhili, A. & Bescharnia, F. (2000) Plant poisonings from herbal medication admitted to a Tunisian toxicology intensive care unit 1983-1998. Vet. Hum. Tox., 42, 137-141.
17. Han, L.K., Ninomiya, H., Taniguchi, M., Kimura, Y. & Okuda, H. (1998) Norepinephrine-augmenting lipolytic effectors from Astilbe thunbergii rhizomes. J. Nat. Prod., 61, 1006-1011.
18. Hattori, T., Ikematsu, S., Koito, A., Matsushita, S., Maeda, Y., Hada, M., Fujimaki, M. & Takatsuki, K. (1989) Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS. Antiviral. Res., 11, 255-261 13.
19. Ito, M., Sato, A., Hirabayashi, K., Tanabe, F., Shigeta, S., Baba, M., De Clercq, E., Nakashima, H. & Yamamoto, N. (1988) Mechanism of inhibitory effect of glycyrrhizin on replication human immunodeficiency virus (HIV). Antiviral Res., 10, 289-298.
20. Kong, J.M., Goh, N.K., Chia, L.S. & Chia, T.F. (2003) Recent advances in traditional plant drugs and orchids. Acta Pharmacol. Sin., 24, 7-21.
21. Lall, N., Das, S.M., Hazra, B. & Meyer, J.J. (2003) Antimycobacterial activity of diospyrin derivatives and a structural analogue of diospyrin against Mycobacterium tuberculosis in vitro. J. Antimicrob. Chemother., 51, 435-438.
22. Lall, N. & Meyer, J.J. (2001) Inhibition of drug sensitive and drug resistant strains of Mycobacterium tuberculosis by diospyrin, isolated from Euclea natalensis. J. Ethnopharamacol., 78, 213-216.
23. Lai, W., Ho, P., Huang, L., Li, Z., Montefiori, D. & Chen, C. (2008) Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of HIV-1. J. Antimicrob. Chemother., 52, 128-136.
24. Mebe, P.P. & Makuhunga, P. (1992) 11-p-Coumaric acid ester of bergenin from Peltophorum africanum. Phytochemistry, 31, 3286-3287.
25. Morris, K. (2002) South Africa tests traditional medicines. Lancet Infect. Dis., 2, 319.
26. Obi, C.L., Potgieter, N., Masebe, T., Mathebula, H. & Molobela, P. (2003) In vitro antibacterial activity of Venda medicinal plants. S. Afri. J. Botany., 69, 199-203.
27. Obi, C.L., Potgieter, N., Randima, L.P., Mavhungu, N.J., Musie, E., Bessong, P.O., Mabogo, D.E.N. & Mashimbye, J. (2002) Antibacterial activity of five medicinal plants against some medically significant human bacteria. S. Afr. J. Sci., 98, 25-28.
28. Piacente, S., Pizza, C., De Tommasi, N. & Mahmood, N. (1996) Constituents of Ardista japonica and their in vitro anti HIV activity. J. Nat. Prod., 59, 565-569.
29. Perelson, A.S., Essunger, P., Cao, Y., Vesanen, M., Hurley, A., Saksela, K., Markowitz, M. & Ho, D.D. (1997) Decay characteristics of HIV-1-infected compartments during combination therapy. Natur., 387, 88-191.
30. Pu, H.L., Huang, X., Zhao, J.H. & Hong, A. (2002) Bergenin is the antiarrhymic principle of Fluggea virosa. Planta Med., 68, 372-374.
31. Takei, M., Kobayashi, M., Li, X.D., Pollard, R.B. & Suzuki, F. (2005) Glycyrrhizin inhibits R5 HIV replication in peripheral blood monocytes treated with 1-methyladenosine. Pathobiology, 72, 117-123.
32. Takeuchi, H., Suzuki, Y., Tatsumi, M., Hoshino, H., Daar, E.S. & Koyanagi Y. (2002) Isolation and characterization of an infectious HIV type 1 molecular clone from a patient with primary infection. AIDS Res. Hum. Retroviruses, 18, 1127-1133.
33. Tillekeratne, L.M.V., Sherette, A., Fulmer, J.A., Hupe, D., Gabbara, S., Peliska, J.A. & Hudson, R.A. (2002) Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase. Bio. Med. Che. Let., 12, 525-528.
34. UNAIDS/WHO (2005) AIDS Epidemic Update, UNAIDS, Geneva, Switzerland, p. 17.
35. Uchida, B., Maeda, Y. & Mitsuya, H. (1997) HIV-1 protease does not play a role in the early stages of HIV-1 infection. Antiviral Res., 36, 107-113.
36. Vlietinck, A.J., De Bruyne, T., Apers, S. & Pieters, L.A. (1998) Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med., 64, 97-109.
37. Wang, R., Gu, Q.,Yang, L., Chen, J., Li, S. & Zheng, Y. (2006) Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis. J. Ethnopharmacol., 105, 269-273.
38. Zhou, J., Yuan, X., Dismuke, D., Forshey, B.M., Lundquist, C., Lee, K.H., Aiken, C. & Chen, C.H. (2004) Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. J. Virol., 78, 922-929.