Review on Labisia pumila (Kacip Fatimah): Bioactive phytochemicals and skin collagen synthesis promoting herb

Fitoterapia

Volumn 83, Issue 8, 2012, Pages 1322-1335

  Chua, Lee Suan ^a   Lee, Sze Yean ^a   Abdullah, Norhanisah ^a   Sarmidi, Mohamad Roji ^a  

^a UNIVERSITI TEKNOLOGI MALAYSIA   (Malaysia)

Author keywords

Collagen synthesis; Labisia pumila; Photoaging; Phytochemical

Indexed keywords

ANTHOCYANIN; APIGENIN; ARDISIACRISPIN A; ARDISICRENOSIDE B; ASCORBIC ACID; AURANTIIN; BELAMCANDOL B; BETA CAROTENE; CAFFEIC ACID; CATECHIN; CHLOROGENIC ACID; COLLAGEN; COUMARIC ACID; DAIDZEIN; EPIGALLOCATECHIN; GALLIC ACID; GENISTEIN; IRISRESORCINOL; KAEMPFEROL; LABISIA PUMILA EXTRACT; MYRICETIN; PLANT MEDICINAL PRODUCT; PROTOCATECHIN ACID; PYROGALLOL; QUERCETIN; RUTOSIDE; SALICYLIC ACID; SYRINGIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLIC ACID;

AGING; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; COLLAGEN SYNTHESIS; DRUG IDENTIFICATION; ESTROGEN DEFICIENCY; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PHOTOAGING; PRIORITY JOURNAL; REVIEW; SKIN CARE; TOXICITY TESTING; ULTRAVIOLET RADIATION;

COLLAGEN; ESTROGENS; HUMANS; MYRSINACEAE; PHYTOESTROGENS; PHYTOTHERAPY; SKIN;

EID: 84870779841     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2012.04.002     Document Type: Review

References (110)

1. B. Sunarno Revision of the genus Labisia (Myrsinaceae) Blumea 50 2005 579 597
2. J.A. Jamal, P.J. Houghton, S.R. Milligan, and I. Jantan The oestrogenic and cytotoxic effects of the extracts of Labisia pumila var. alata and Labisia pumila var. pumila in vitro Sains Kesihatan 1 2003 53 60
3. M.F. Wan Ezumi, S. Siti Amrah, A.W.M. Suhaimi, and S.S.J. Mohsin Evaluation of the female reproductive toxicity of aqueous extract of Labisia pumila var. alata in rats Indian J Pharmacol 39 2007 30 32
4. I.H. Burkill, A dictionary of the economic products of the Malay Peninsula, Ministry of Agriculture Malaysia (Ed.), Crown Agents for the Colonies, London, 1935.
5. S.P. Runi Studies on medicinal plant in Sarawak Y.S. Chang, Towards bridging science and herbal industry Proc. sem. medicinal aromatic plants, Forest Research Institute Malaysia, Kepong 2000 112 119
6. I.H. Burkill A dictionary of the economic product of the Malay Peninsula Vol. II (I-Z) Government of Malaysia and Singapore by the Ministry of Agriculture and Cooperative, Kuala Lumpur 1966
7. M. Hartinie, and G.A. Jualang In vitro germination and plantlet establishment of Labisia pumila (B1.) F. Vill Sci Hortic 115 2007 91 97
8. H.Z.E. Jaafar, M.H. Ibrahim, and E. Philip Leaf gas exchange properties of three varieties of Labisia pumila Benth. under green house conditions J. Trop Plant Physiol 3 2009 16 24
9. M.H. Ibrahim, and H.Z.E. Jaafar Photosynthetic capacity, photochemical efficiency and chlorophyll content of three varieties of Labisia pumila Benth. exposed to open field and greenhouse growing conditions Acta Physiol Plant 33 2011 2179 2185
10. Z. Rohizawati, H. Aminah, and N. Lokman Preliminary trial on rooting ability of Labisia pumila cuttings Malaysian sci. technol. congress, agriculture sci., Kuala Lumpur 2003
11. L.S. Chua, N. Abdul Latiff, S.Y. Lee, C.T. Lee, M.R. Sarmidi, and R. Abdul Aziz Flavonoids and phenolic acids from Labisia pumila (Kacip Fatimah) Food Chem 127 2011 1186 1192
12. E. Karimi, H.Z.E. Jaafar, and S. Ahmad Phytochemical analysis and antimicrobial activities of methanolic extracts of leaf, stem and root from different varieties of Labisa pumila Benth Molecules 16 2011 4438 4450
13. E. Karimi, and H.Z.E. Jaafar HPLC and GC-MS determination of bioactive compounds in microwave obtained extracts of three varieties of Labisia pumila Benth Molecules 16 2011 6791 6805
14. M. Norhaiza, M. Maziah, and M. Hakiman Antioxidative properties of leaf extracts of a popular Malaysian herb, Labisia pumila J Med Plant Res 3 2009 217 223
15. M. Bagchi, M. Mark, W. Casey, B. Jaya, Y. Xumei, and S. Sidney Acute and chronic stress-induced oxidative gastrointestinal injury in rats and the protective ability of a novel grape seed proanthocyanidin extract Nutr Res 19 1999 1189 1199
16. G. Pandey, and S. Madhuri Some medicinal plants as natural anticancer agents Pharmacogn Rev 3 2009 259 263
17. A.H.L. Pihie, F. Othman, and Z.A. Zakaria Anticarcinogenic activity of Labisia pumila against 7,12-dimethylbenz(α)anthracene (DMBA)/croton oil-induced mouse skin carcinogenesis Afr J Pharm Pharmacol 5 2011 823 832
18. B. Avula, Y.H. Wang, Z. Ali, T.J. Smillie, and I.A. Khan Quantitative determination of triterpene saponins and alkenated-phenolics from Labisia pumila using an LC-UV/ELSD method and confirmation by LC-ESI-TOF Planta Med 77 2011 1742 1748
19. Z. Ali, and I.A. Khan Alkyl phenols and saponins from the roots of Labisia pumila (Kacip Fatimah) Phytochem 72 2011 2075 2080
20. S.G. Sparg, M.E. Light, and J. van Staden Biological activities and distribution of plant saponins J Ethnopharmacol 94 2004 219 243
21. E. Nocerino, M. Amato, and A.A. Izzo The aphrodisiac and adaptogenic properties of ginseng Fitoterapia 71 2000 S1 S5
22. Institute for Medical Research, estrogenic and androgenic activities of Kacip Fatimah (Labisia pumila) Malaysian Herbal Medicine Research Center 2002 Ministry of Health Malaysia Kuala Lumpur 8
23. E.E. Kershaw, and J.S. Flier Adipose tissue as an endocrine organ J Clin Endocrinol Metab 89 2004 2548 2556
24. A. Al-Wahaibi, W.M. Wan Nazaimoon, H.S. Farihah, and A.L. Azian Effect of ovariectomy, Labisia pumila var. alata treatment and estrogen replacement therapy on the morphology of adipose tissue in ovariectomized Sprague Dawley rats J Med 1 2007 1 7
25. A.A. Ariyo, and A.C. Villablanca Estrogens and lipids: can HRT designer estrogens, and phytoestrogen reduce cardiovascular risk markers after menopause? Postgrad Med 111 2002 23 30
26. A. Al-Wahaibi, W.M. Wan Nazaimoon, W.N. Norsyam, H.S. Farihah, and A.L. Azian Effect of water extract of Labisia pumila var alata on aorta of ovariectomized Sprague Dawley rats, Pakistan J Nutr 7 2008 208 213
27. H.J. Teede, F.S. Dalais, D. Kotsopoulos, Y.L. Liang, S. Davis, and B.P. McGrath Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women J Clin Endocrinol Metab 86 2001 3053 3060
28. P.J. Nestel, T. Yamashita, T. Sasahara, S. Pomeroy, A. Dart, and P. Komesaroff Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women Arterioscler Thromb Vasc Biol 17 1997 3392 3398
29. S.J. Bhathena, and M.T. Velasquez Beneficial role of dietary phytoestrogens in obesity and diabetes Am J Clin Nutr 76 2002 1191 1201
30. Y.T. van der Schouw, A. Pijpe, C.E.I. Lebrun, M.L. Bots, P.H.M. Peeters, and W.A. van Staveren Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women Arterioscler Thromb Vasc Biol 22 2002 1316 1322
31. Y.T. van der Schouw, S. Kreijkamp-Kaspers, P.H.M. Peeters, L. Keinan-Boker, E.B. Rimm, and D.E. Grobbee Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in western women Circ 111 2005 465 471
32. M. Fazliana, W.M. Wan Nazaimoon, H.F. Gu, and C.G. Ostenson Labisia pumila extract regulates body weight and adipokines in ovariectomized rats Maturitas 62 2009 91 97
33. L. Manneras, M. Fazliana, W.M. Wan Nazaimoon, M. Lonn, H.F. Gu, and C.G. Ostenson Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome J Ethnopharmacol 127 2010 346 351
34. S.W. Huang, K.M. Seow, L.T. Ho, Y. Chien, D.Y. Chung, and C.L. Chang Resistin mRNA levels are downregulated by estrogen in vivo and in vitro FEBS Lett 579 2005 449 454
35. C.M. Steppan, and M.A. Lazar The current biology of resistin J Intern Med 255 2004 439 447
36. C. Weyer, T. Funahashi, S. Tanaka, K. Hotta, Y. Matsuzawa, and R.E. Pratley Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia J Clin Endocrinol Metab 86 2001 1930 1935
37. N.S. Ahmad, L.L. Leong, M. Norliza, M. Norazlina, and N.S. Ima The effects of Labisia pumila var. alata on bone markers and bone calcium in a rat model of post-menopausal osteoporosis J Ethnopharmacol 133 2011 538 542
38. M. Fazliana, N.L. Ramos, P. Luthje, M. Sekikubo, A. Holma, and W.M. Wan Nazaimoon Labisia pumila var. alata reduces bacterial load by inducing uroepithelial cell apoptosis J Ethnopharmacol 136 2011 111 116
39. A. Pandey, S. Bani, P. Sangwan, and S. Koul Selective Th1 upregulation by ethyl acetate fraction of Labisia pumila J Ethnopharmacol 132 2010 309 315
40. T.G. Sambandan, B.K. Ong, A. Norhaniza, A. Mohd Puad, and C.K. Rha Quantitative measurement of chemical or bioactive constituents of Eurycoma Longifolia (Tongkat Ali) Herbal Asia, Kuala Lumpur, Malaysia, 25-28 March 2004 2004
41. O. Asiah, M.Y. Nurhanan, and A. Mohd Ilham Determination of bioactive peptide (4.3 kDa) as an aphrodisiac marker in six Malaysian plants J Trop For Sci 19 2007 61 63
42. Z. Shahrim, P.J.N.M. Baharuddin, N.A. Yahya, H. Muhammad, R.A. Bakar, and Z. Ismail The in vivo rodent micronucleus assay of Kacip Fatimah (Labisia pumila) extract Trop Biomed 23 2006 214 219
43. G. Krishna, and M. Hyashi In vivo rodent micronucleus assay: protocol, conduct and data interpretation Mutat Res 455 2000 155 166
44. W.E. Mohd Fuad, S.A. Sulaiman, M.N. Islam, M.S. Abdul Wahab, and S.M.S. Jamalullail Evaluation of the teratogenicity of aqueous extract of Labisia pumila var. alata in rats Malaysian J Med Sci 12 2005 13 21
45. A.W.M. Effendy, J. Siti-Nurtahirah, and Z.M. Hussin The side effects of Kacip Fatimah extract on liver and kidney of white rats J Sustainable Sci Manage 1 2006 40 46
46. G.D. Singh, M. Ganjoo, M.S. Youssouf, A. Koul, R. Sharma, and S. Singh Sub-acute toxicity evaluation of an aqueous extract of Labisia pumila, a Malaysian herb Food Chem Toxicol 47 2009 2661 2665
47. M.S.S.S.S. Saravi The chemistry, pharmacology and clinical properties of Sambucus ebulus: a review J Med Plant Res 4 2010 96 103
48. M.F. María Elena Cartea, P. Soengas, and P. Velasco Phenolic compounds in brassica vegetables Molecules 16 2011 251 280
49. J.S. Perona, R. Cabello-Moruno, and V. Ruiz-Gutierrez The role of virgin olive oil components in the modulation of endothelial function J Nutr Biochem 17 2006 429 445
50. P.K. Mukherjee, N. Maity, N.K. Nema, and B.K. Sarkar Bioactive compounds from natural resources against skin aging Phytomedicine 19 2011 64 73
51. K. Kour, N. Sharma, B.K. Chandan, S. Koul, P.L. Sangwan, and S. Bani Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations Planta Med 76 2010 1497 1505
52. N.V. Lazarev Actual problems of the studies of the action of adaptogens, particularly preparations of Eleuterococcus, symposium on ginseng and Eleuterococcus XX meeting on investigations of ginseng and other medicinal plants of Far East 1962 DVFSO Vladivostok 7 14
53. R.J. Wenstrup, M.S. Pinnell, and S.R. Ehler-Danlos Syndrome type IV: clinical manifestation of collagen lysyl hydroxylase deficiency J Pediatr 115 1989 405 409
54. T. Moore Relation of carotin to vitamin A Lancet 2 1929 380 381
55. K.A. Madani Retinoic acid: a general overview Nutr Res 6 1986 107 123
56. M.D. Hegsted, C.O. Chichester, W.J. Darby, K.W. McNutt, R.M. Stalvey, and E.H. Stotz Present knowledge in nutrition fourth ed. 1976 Nutrition Foundation New York 64 72
57. C.E. Griffiths, A.N. Russman, G. Majmudar, R.S. Singer, T.A. Hamilton, and J.J. Voorhees Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid) N Engl J Med 329 1993 530 535
58. R.A. Breg, and D.J. Prockop The thermal transition of a non-hydroxylated form of collagen: evidence for the role of hydroproline in stabilizing the triple helix of collagen Biochem Biophys Res Commun 52 1973 115 120
59. C.L. Phillips, S.B. Combs, and S.R. Pinnell Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human dermal fibroblasts J Invest Dermatol 103 1994 228 232
60. R.L. Hata, and H. Senoo l-ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissue-like substance by skin fibroblasts J Cell Physiol 138 1989 8 16
61. T.M. Hering, J. Kollar, T.D. Huynh, J.B. Varelas, and L.J. Sandell Modulation of extracellular matrix gene expression in bovine high-density chondrocyte cultures by ascorbic acid and enzymatic resuspension Arch Biochem Biophys 314 1994 90 98
62. M. Richelle, H. Steiling, and I. Castiel R. Blair, A. Tabor, Bioavailability and skin bioefficacy of vitamin C and E in nutritional cosmetics: beauty from within 2009 William Andrew (Elsevier) New York 113 138
63. J.J. Thiele, and S. Ekanayake-Mudiyanselage Vitamin E in human skin: organ-specific physiology and considerations for its use in dermatology Mol Aspects Med 28 2007 646 667
64. J. Zussman, J. Ahdout, and J. Kim Vitamins and photoaging: do scientific data support their use? J Am Acad Dermatol 63 2010 507 525
65. R. Ricciarelli, P. Maroni, N. Ozer, J. Zingg, and A. Azzi Age-dependent increase of collagenase expression can be reduced by α-tocopherol via protein kinase C inhibition Free Radic Biol Med 27 1999 729 737
66. D.L. Bissett, R. Chatterjee, and D.P. Hannon Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse Photodermatol Photoimmunol Photomed 7 1990 56 62
67. 10: contents in foods and dietary intake J Food Compos Anal 14 2001 409 417
68. L.F. Crane Discovery of ubiquinone (coenzyme Q) and an overview of function Mitochondrion 7 2007 S2 S7
69. Y. Tian, T. Yue, Y. Yuan, P.K. Soma, P.D. Williams, and P.A. Machado Tobacco biomass hydrolysate enhances coenzyme Q10 production using photosynthetic Rhodospirillum rubrum Bioresour Technol 101 2010 7877 7881
70. D.M. Kyriazis The anti aging plan: stay young longer 2000 Element Books Limited 1 30
71. R. Arking The biology of aging: observations and principles third ed. 2006 Oxford University Press 3 25
72. D. Cernasov Design and development of anti-aging formulations Skin aging handbook: an integrated approach to biochemistry and product development 2008 William Andrew Inc. New Jersey 291 325
73. G. Jenkins Molecular mechanisms of skin ageing Mech Ageing Dev 123 2002 801 810
74. R. Nair, M. Sevukarajan, and T.M.C.K. Ashok Kumar Collagen based drug delivery systems: a review J Innovative Trends Pharm Sci 1 2010 288 304
75. L. Weber, E. Kirsch, P. Muller, and T. Krieg Collagen type distribution and macromolecular organization of connective tissue in different layers of human skin J Invest Dermatol 82 1984 156 160
76. R. Fleischmajer, J.S. Perlish, R.E. Burgeson, F. Shaikh-Bahai, and R. Timpl Type I and type III collagen interactions during fibrillogenesis Ann N Y Acad Sci 580 1990 161 175
77. M. Braverman, and E. Fonferko Studies in cutaneous aging: I. The elastic fibre network J Invest Dermatol 78 1982 434 443
78. H.S. Talwar, C.E.M. Griffioth, G.J. Fisher, T.A. Hamilton, and J.J. Voorhees Reduced type I and type III procollagens in photodamaged adult human skin J Invest Dermatol 105 1995 285 290
79. L. Pascual-Le Tallec, C. Korwin-Zmijowska, and M. Adolphe Effects of simulated solar radiation on type I and type III collagens, collagenase (MMP-1) and stromelysin (MMP-3) gene expression in human dermal fibroblasts cultured in collagen gels J Photochem Photobiol B 42 1998 226 232
80. M. Dumas, C. Chaudagne, F. Bonte, and A. Meybeck In vitro biosynthesis of type I and III collagens by human dermal fibroblasts from donors of increasing age Mech Ageing Dev 73 1994 179 187
81. K. Takeda, A. Gosiewska, and B. Peterkofsky Similar, but not identical, modulation of expression of extracellular matrix components during in vitro and in vivo aging of human skin fibroblasts J Cell Physiol 153 1992 450 459
82. F. Vazquez, S. Palacios, N. Aleman, and F. Guerrero Changes of the basement membrane and type IV collagen in human skin during aging Maturitas 25 1996 209 215
83. P.K. Mays, J.E. Bishop, and G.J. Laurent Age-related changes in the proportion of types I and III collagen Mech Ageing Dev 45 1988 203 212
84. J.G. Smith, E.A. Davidson, W.M. Sams, and R.D. Clark Alterations in human dermal connective tissue with age and chronic sun damage J Invest Dermatol 39 1962 347 350
85. H. Choi, D. Kim, J.W. Kim, S. Ngadiran, and M.R. Sarmidi Labisia pumila extract protects skin cells from photoaging caused by UVB irradiation J Biosci Bioeng 109 2010 291 296
86. N. Chondrogianni, S. Kapeta, L. Chinou, K. Vassilatou, I. Papassideri, and E.S. Gonos Anti-ageing and rejuvenating effects of quercetin Exp Gerontol 45 2010 763 771
87. D.O. Kim, S.W. Jeong, and C.Y. Lee Antioxidant capacity of phenolic phytochemicals from various cultivars of plum Food Chem 81 2003 321 326
88. W. Köpcke, and J. Krutmann Protection from sunburn with beta-carotene: a meta-analysis Photochem Photobiol 84 2008 284 288
89. 2 and nitrogen fertilization Molecules 16 2011 162 174
90. A.J. Jamia, and P.J. Houghton Alkenyl resinols from Labisia pumila var. alata Natural products research in Malaysia 1999 Universiti Sains Malaysia Pulau Pinang 45 46
91. T. Stipcevic, J. Piljac, and D. Vanden Berghe Effect of different flavonoids on collagen synthesis in human fibroblasts Plant Foods Hum Nutr 61 2006 29 34
92. K. von der Mark Structure, biosynthesis and gene regulation of collagens in cartilage and bones M.J. Seibel, S.P. Robins, J.P. Bilezikian, Dynamics of bone and cartilage metabolism 1999 Academic Press Orlando 3 29
93. M.C. Ryan, and L.J. Sandell Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA J Biol Chem 265 1990 10334 10339
94. R.F. Diegelmann, and M.C. Evans Wound healing: an overview of acute, fibrotic and delayed healing Front Biosci 9 2004 283 289
95. S. Leoni, M. Marino, L.C. Devirgiliis, S. Spagnuolo, S. Beninati, and M.T. Mangiantini Age-related changes of glycosylation pattern in isolated rat hepatocytes Mech Ageing Dev 56 1990 169 178
96. K.E. Kadler, D.F. Holmes, J.A. Trotter, and J.A. Chapman Collagen fibril formation Biochem J 316 1996 1 11
97. E. Straface, M. Falchi, P.U. Giacomoni, and W. Malorni Cytotoxicity and morphological endpoints of exposure to UV: cultured cells as a model system P.U. Giacomoni, Comprehensive series in photosciences 3 2001 Elsevier Science 321 336
98. M. Berneburg, and J. Krutmann Photoimmunology, DNA repair and photocarcinogenesis J Photochem Photobiol B B54 2000 87 93
99. J. Krutmann Ultraviolet a radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis J Dermatol Sci 23 2000 22 26
100. M.S. Duthie, I. Kimber, and M. Norval The effects of ultraviolet radiation on the human immune system Br J Dermatol 140 1999 995 1009
101. D.A. Hall, F.B. Reed, G. Nuki, and J.D. Vince The relative effects of age and corticosteroid therapy on the collagen profile of subjects from dermis with rheumatoid arthritis Age Ageing 3 1974 15 22
102. S. Shuster, M.M. Black, and E. MacVitie The influence of age and sex on skin thickness, skin collagen and density Br J Dermatol 93 1975 639 643
103. G.J. Fisher, H.S. Talwar, J. Lin, P. Lin, F. McPhillips, and Z. Wang Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo J Clin Invest 101 1998 1432 1440
104. M. Berneburg, H. Plettenberg, and J. Krutmann Photoaging of human skin Photodermatol Photoimmunol Photomed 16 2000 239 244
105. K. Scharffetter-Kochanek, P. Brenneisen, J. Wenk, G. Herrmann, W. Ma, and L. Kuhr Photoaging of the skin: from phenotype to mechanisms Exp Gerontol 35 2000 307 316
106. J. Wenk, P. Brenneisen, C. Meewes, M. Wlaschek, T. Peters, and R. Blaudschun UV induced oxidative stress and photoaging Curr Probl Dermatol 29 2001 83 94
107. K.K. Dong, N. Damaghi, S.D. Picart, N.G. Markova, K. Obayashi, and Y. Okano UV-induced DNA damage initiates release of MMP-1 in human skin Exp Dermatol 17 2008 1037 1044
108. G.J. Fisher, Z.Q. Wang, S.C. Datta, J. Varani, S. Kang, and J.J. Voorhees Pathophysiology of premature skin aging induced by ultraviolet light N Engl J Med 337 1997 1419 1428
109. G.J. Fisher, S. Datta, Z.Q. Wang, X.Y. Li, T. Quan, and J.H. Chung c-Jun dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoid acid J Clin Invest 106 2000 663 670
110. P.J. Houghton, J.A. Jamal, and S.R. Milligan Studies on Labisia pumila herb and its commercial products J Pharm Pharmacol (Suppl) 51 1999 236