Ouabain mimics low temperature rescue of f508del-CFTR in cystic fibrosis epithelial cells

Frontiers in Pharmacology

Volumn 3 OCT, Issue , 2012, Pages

  Zhang, Donglei ^a   Ciciriello, Fabiana ^a,b   Anjos, Suzana M ^a   Carissimo, Annamaria ^b   Liao, Jie ^a   Carlile, Graeme W ^a   Balghi, Haouaria ^a   Robert, Renaud ^a   Luini, Alberto ^b,c   Hanrahan, John W ^a   Thomas, David Y ^a  

^a MCGILL UNIVERSITY   (Canada)

^b TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^c INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

Author keywords

CFBE cells; Cftr; Connectivity map; Cystic fibrosis; Hierarchical clustering; Microarray; Quabain; Trafficking

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; OUABAIN;

ANIMAL EXPERIMENT; ARTICLE; BRONCHUS MUCOSA; CELL SURFACE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; DRUG MECHANISM; EPITHELIUM CELL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LOW TEMPERATURE; MIGRATION INHIBITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN TRANSPORT; TEMPERATURE MEASUREMENT; TRANSCRIPTION INITIATION;

EID: 84870719819     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00176     Document Type: Article

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