Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from fibrosis lung epithelial cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 20, 2004, Pages 7693-7698

  Srivastava, Meera ^a   Eidelman, Ofer ^a   Zhang, Jian ^a   Paweletz, Cloud ^a   Caohuy, Hung ^a   Yang, QingFeng ^a   Jacobson, Kenneth A ^b   Heldman, Eliahu ^a,c   Huang, Wei ^a   Jozwik, Catherine ^a   Pollard, Bette S ^d   Pollard, Harvey B ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d Office of Information Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,12 DIACETYLDIGITOXIGENIN; ACETYLSTROPHANTHIDIN; CARDIAC GLYCOSIDE; DIGITOXIGENIN; DIGITOXIN; DIGOXIGENIN; DIGOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; OLEANDRIN; OUABAIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL LINE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; EPITHELIUM CELL; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PATHOPHYSIOLOGY; PHARMACOGENETICS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

CARDIAC GLYCOSIDES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIGITOXIN; ENZYME INHIBITORS; EPITHELIUM; GENE THERAPY; I-KAPPA B PROTEINS; INTERLEUKIN-8; LUNG;

STROPHANTHUS GRATUS;

EID: 2442652835     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0402030101     Document Type: Article

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