Assessment of stable isotope incorporation into recombinant proteins

Analytical Biochemistry

Volumn 433, Issue 2, 2013, Pages 137-149

  Zhang, Xin ^a   Luo, Quanzhou ^a   Apostol, Izydor ^a   Luo, Shun ^a   Jerums, Matthew ^a   Huang, Gang ^a   Jiang, Xinzhao Grace ^a   Gastwirt, Jessica ^a   Savjani, Nimesh ^a   Lewis, Jeffrey ^a   Keener III, Ronald ^a   Wypych, Jette ^a  

^a AMGEN INC   (United States)

Author keywords

Mass spectrometry; Quantitative assessment of stable isotope incorporation; Stable isotope labeling

Indexed keywords

CELL CULTURE; ISOTOPES; MASS SPECTROMETRY; METABOLISM; MONOCLONAL ANTIBODIES;

AMINO ACID ANALYSIS; BIOANALYTICAL TOOLS; BIOMEDICAL FIELDS; COMPREHENSIVE ASSESSMENT; FC FUSION PROTEINS; METABOLIC LABELING; STABLE ISOTOPES; STABLE-ISOTOPE LABELING;

RECOMBINANT PROTEINS;

CARBON 13; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G2; NITROGEN 15; NONESSENTIAL AMINO ACID; RECOMBINANT PROTEIN; STABLE ISOTOPE;

AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; CAPILLARY ELECTROPHORESIS; CELL CULTURE; CELL METABOLISM; CHO CELL; CONTROLLED STUDY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84870656120     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2012.10.013     Document Type: Article

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