Comparability analysis of protein therapeutics by bottom-up LC-MS with stable isotope-tagged reference standards

mAbs

Volumn 3, Issue 4, 2011, Pages 387-395

  Manuilov, Anton V ^a   Radziejewski, Czeslaw H ^a   Lee, David H ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Comparability; LC MS; Mass spectrometry; Monoclonal antibodies; Peptide mapping; Protein therapeutics; SITRS; Stable isotope tagged reference standard

Indexed keywords

ARGININE; CARBON 13; LYSINE; MONOCLONAL ANTIBODY; STABLE ISOTOPE; TRYPSIN; BIOLOGICAL PRODUCT; CARBON; PROTEIN;

ANIMAL CELL; ARTICLE; DEAMINATION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PEPTIDE MAPPING; PROTEIN ANALYSIS; PROTEIN STABILITY; ANIMAL; BIOSYNTHESIS; CELL STRAIN HEK293; CHEMISTRY; CHO CELL; COMPARATIVE STUDY; EVALUATION; HAMSTER; ISOTOPE LABELING; METABOLISM; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STANDARD;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL AGENTS; CARBON ISOTOPES; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; HEK293 CELLS; HUMANS; ISOTOPE LABELING; MASS SPECTROMETRY; PEPTIDE MAPPING; PROTEINS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 79960108436     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.3.4.16237     Document Type: Article

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