Brugada syndrome: Two decades of progress

Circulation Journal

Volumn 76, Issue 12, 2012, Pages 2713-2722

  Veerakul, Gumpanart ^a   Nademanee, Koonlawee ^b,c  

^a BHUMIBOL ADULYADEJ HOSPITAL   (Thailand)

^b Bangkok Medical Center   (Thailand)

^c White Memorial Medical Center   (United States)

Author keywords

Ablation; Electrophysiology; Genetics; Ion channels; Ventricular arrhythmia

Indexed keywords

AJMALINE; CALCIUM ION; FLECAINIDE; ISOPRENALINE; POTASSIUM ION; PROCAINAMIDE; QUINIDINE; SODIUM CHANNEL NAV1.5; SODIUM ION;

BODY TEMPERATURE; BRUGADA SYNDROME; CATHETER ABLATION; COMPUTER ASSISTED TOMOGRAPHY; EATING HABIT; ELECTROCARDIOGRAPHY; ELECTROGRAPHY; FEVER; GENE MUTATION; GENETIC SCREENING; HEART ARRHYTHMIA; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART MUSCLE POTENTIAL; HEART RATE; HEART VENTRICLE FIBRILLATION; HUMAN; HYPOKALEMIA; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; ION CURRENT; LONG QT SYNDROME; POSTOPERATIVE COMPLICATION; REVIEW; SLEEP; ST SEGMENT ELEVATION; SYMPATHETIC TONE; THROMBOCYTOPENIA;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BRUGADA SYNDROME; CATHETER ABLATION; DEFIBRILLATORS, IMPLANTABLE; ELECTRIC COUNTERSHOCK; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; GENETIC PREDISPOSITION TO DISEASE; HEART CONDUCTION SYSTEM; HUMANS; MUTATION; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PHENOTYPE; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; RISK FACTORS; THAILAND; TREATMENT OUTCOME;

EID: 84870570379     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-12-1352     Document Type: Review

References (103)

1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome: A multicenter report. J Am Coll Cardiol 1992; 20: 1391-1396.
2. Nademanee K, Veerakul G, Nimmannit S, Chaowakul V, Bhuripanyo K, Likittanasombat K, et al. Arrhythmogenic marker for the sudden unexplained death syndrome in Thai men. Circulation 1997; 96: 2595-2600.
3. Vatta M, Dumaine R, Varghese G, Richard TA, Shimizu W, Aihara N, et al. Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome. Hum Mol Genet 2002; 11: 337-345.
4. Wilde AAM, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, et al. Proposed diagnostic criteria for the Brugada syndrome: Consensus report. Circulation 2002; 106: 2514-2519.
5. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, et al. Brugada syndrome: Report of the second consensus conference: Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005; 111: 659-670.
6. Mizusawa Y, Wilde A. Brugada syndrome. Circ Arrhythm Electro-physiol 2012; 5: 606-616.
7. Antzelevitch C. Genetic, molecular and cellular mechanisms underlying the J wave syndromes. Circ J 2012; 76: 1054-1065.
8. Probst V, Wilde AA, Barc J, Sacher F, Babuty D, Mabo P, et al. SCN5A mutations and the role of genetic 723 background in the pathophysiology of Brugada syndrome. Circ Cardiovasc Genet 2009; 2: 552-557.
9. Nademanee K, Veerakul G, Chandanamattha P, Chaothawee L, Ariyachaipanich A, Jirasirirojanakorn K, et al. Prevention of ventricular fbrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outfow tract epicardium. Circulation 2011; 123: 1270-1279.
10. Wilde AA, Postema PG, Di Diego JM, Viskin S, Morita H, Fish JM, et al. The pathophysiological mechanism underlying Brugada syndrome: Depolarization versus repolarization. J Mol Cell Cardiol 2010; 49: 543-553.
11. Priori SG, Gasparini M, Napolitano C, Della Bella P, Ottonelli AG, Sassone B, et al. Risk Stratifcation in Brugada syndrome: Results of the PRELUDE (Programmed Electrical stimulation predictive valuE) Registry. J Am Coll Cardiol 2012; 59: 37-45.
12. Brugada J, Brugada R, Antzelevitch C, Towbin J, Nademanee K, Brugada P. Long-term follow-up of individuals with the electrocar-diographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. Circulation 2002; 105: 73-78.
13. Probst V, Veltmann C, Eckardt L, Meregalli PG, Gaita F, Tan HL, et al. Long-term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry. Circulation 2010; 121: 635-643.
14. Kamakura S, Ohe T, Nakazawa K, Aizawa Y, Shimizu A, Horie M, et al. Long-term prognosis of probands with Brugada-pattern ST-elevation in leads V1-V3. Circ Arrhythm Electrophysiol 2009; 2: 495-503.
15. Paul M, Gerss J, Schulze-Bahr E, Wichter T, Vahlhaus C, Wilde AA, et al. Role of programmed ventricular stimulation in patients with Brugada syndrome: A meta-analysis of worldwide published data. Eur Heart J 2007; 28: 2126-2133.
16. Eckardt L, Probst V, Smits JP, Bahr ES, Wolpert C, Schimpf R, et al. Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome. Circulation 2005; 111: 257-263.
17. Takagi M, Yokoyama Y, Aonuma K, Aihara N, Hiraoka M. Clinical characteristics and risk stratifcation in symptomatic and asymptomatic patients with Brugada syndrome: Multicenter study in Japan. J Cardiovasc Electrophysiol 2007; 18: 1244-1251.
18. Giustetto C, Drago S, Demarchi PG, Dalmasso P, Bianchi F, Masi AS, et al. Risk stratifcation of the patients with Brugada type electrocardiogram: A community-based prospective study. Europace 2009; 11: 507-513.
19. Viskin S, Rogowski O. Asymptomatic Brugada syndrome: A cardiac ticking time-bomb? Europace 2007; 9: 707-710.
20. Gumpanart V, Camblock J, Schwab M, Nademanee K. Low mortality rate among asymptomatic Brugada syndrome patients: A multi-center control-randomized study comparing ICD versus no-ICD treatment. Circulation 2008; 118: S982.
21. Probst V, Denjoy I, Meregalli PG, Amirault JC, Sacher F, Mansourati J, et al. Clinical aspects and prognosis of Brugada syndrome in children. Circulation 2007; 115: 2042-2048.
22. Benito B, Sarkozy A, Mont L, Henkens S, Berruezo A, Tamborero D, et al. Gender differences in clinical manifestations of Brugada syndrome. J Am Coll Cardiol 2008; 52: 1567-1573.
23. Miyasaka Y, Tsuji H, Yamada K, Tokunaga S, Saito D, Imuro Y, et al. Prevalence and mortality of the Brugada-type electrocardiogram in one city in Japan. J Am Coll Cardiol 2001; 38: 771-774.
24. Veerakul G, Chaothawee L, Nademanee K. Usefulness of positioning ECG leads at V1-3 at higher intercostal spaces to detect Brugada syndrome. Circulation 2000; 102(Suppl): 18.
25. Shimizu W, Matsuo K, Takagi M, Tanabe Y, Aiba T, Taguchi A, et al. Body surface distribution and response to drugs of ST segment elevation in Brugada syndrome: Clinical implication of eighty-seven-lead body surface potential mapping and its application to twelve-lead electrocardiograms. J Cardiovasc Electrophysiol 2000; 11: 396-404.
26. Govindan M, Batchvarov VN, Raju H, Shanmugam N, Bizrah M, Bastiaenen R, et al. Utility of high and standard right precordial leads during ajmaline testing for the diagnosis of Brugada syndrome. Heart 2010; 96: 1904-1908.
27. Holst AG, Tango M, Batchvarov V, Govindan M, Haunsø S, Svendsen JH, et al. Specifcity of elevated intercostal space ECG recording for the type 1 Brugada ECG pattern. Ann Noninvasive Electrocardiol 2012; 17: 108-112.
28. Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, et al. Genetic basis and molecular mechanism for idiopathic ventricular fbrillation. Nature 1998; 392: 293-296.
29. Priori SG, Napolitano C, Giordano U, Collisani G, Memmi M. Brugada syndrome and sudden cardiac death in children. Lancet 2000; 355: 808-809.
30. Valdivia CR, Tester DJ, Rok BA, Porter CB, Munger TM, Jahangir A, et al. A traffcking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs. Cardiovasc Res 2004; 62: 53-62.
31. Kyndt F, Probst V, Potet F, Demolombe S, Chevallier JC, Baro I, et al. Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family. Circulation 2001; 104: 3081-3086.
32. Valdivia CR, Tester DJ, Rok BA, Porter CB, Munger TM, Jahangir A, et al. A traffcking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs. Cardiovasc Res 2004; 62: 53-62.
33. Bezzina C, Veldkamp MW, van den Berg MP, Postma AV, Rook MB, Viersma JW, et al. A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Circ Res 1999; 85: 1206-1213.
34. Dumaine R, Towbin JA, Brugada P, Vatta M, Nesterenko DV, Nesterenko VV, et al. Ionic mechanisms responsible for the elec-trocardiographic phenotype of the Brugada syndrome are temperature dependent. Circ Res 1999; 85: 803-809.
35. Akai J, Makita N, Sakurada H, Shirai N, Ueda K, Kitabatake A, et al. A novel SCN5A mutation associated with idiopathic ventricular fbrillation without typical ECG fndings of Brugada syndrome. FEBS Lett 2000; 479: 29-34.
36. + channel does not affect ion selectivity properties. Acta Physiol Scand 2005; 185: 291-301.
37. + channelopathies and sinus node dysfunction. Prog Biophys Mol Biol 2008; 98: 171-178.
38. Kapplinger JD, Tester DJ, Alders M, Benito B, Berthet M, Brugada J, et al. An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm 2010; 7: 33-46.
39. Tan HL, Hofman N, van Langen IM, van der Wal AC, Wilde AA. Sudden unexplained death: Heritability and diagnostic yield of car-diological and genetic examination in surviving relatives. Circulation 2005; 112: 207-213.
40. Sakabe M, Fujiki A, Tsuneda T, Nishida K, Sugao M, Mizumaki K, et al. Brugada syndrome occurring in an identical twin: A case report. J Cardiol 2002,40: 111-115 (in Japanese).
41. Wang Q, Shen J, Splawski I, Atkinson D, Li Z, Robinson JL, et al. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 1995; 80: 805-811.
42. Tan HL, Bink-Boelkens MT, Bezzina CR, Viswnathan PC, Beaufort-Krol GC, van Tintelen PJ, et al. A sodium-channel mutation causes isolated cardiac conduction disease. Nature 2001; 409: 1043-1047.
43. Benson DW, Wang DW, Dyment M, Knilans TK, Fish FA, Strieper MJ, et al. Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest 2003; 112: 1019-1028.
44. Darbar D, Kannankeril PJ, Donahue BS, Kucera G, Stubblefeld T, Haines JL, et al. Cardiac sodium channel (SCN5A) variants associated with atrial fbrillation. Circulation 2008; 117: 1927-1935.
45. Olson TM, Michels VV, Ballew JD, Reyna SP, Karst ML, Herron KJ, et al. Sodium channel mutations and susceptibility to heart failure and atrial fbrillation. JAMA 2005, 293: 447-454.
46. Meregalli PG, Tan HL, Probst V, Koopmann TT, Tanck MW, Bhuiyan ZA, et al. Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies. Heart Rhythm 2009; 6: 341-348.
47. Crotti L, Marcou CA, Tester DJ, Castelletti S, Giudicessi JR, Torchio M, et al. Spectrum and prevalence of mutation involving BS1-through BS12- susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing implication for genetic testing. J Am Coll Cardiol 2012, 60: 1410-1418.
48. Gollob MH, Blier L, Brugada R, Champagne J, Chauhan V, Connors S, et al. Recommendation for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death: Canadian Cardiovascular Society/Canadian Heart Rhythm Society joint position paper. Can J Cardiol 2011; 27: 232-245.
49. Ackerman M, Priori S, Willems S, Berul C, Brugada R, Calkins H, et al. HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies. Heart Rhythm 2011; 8: 1308-1339.
50. Kaufman E. Genetic testing in Brugada syndrome. J Am Coll Car-diol 2012; 60: 1419-1420.
51. Antzelevitch C. The Brugada syndrome. J Cardiovasc Electro-physiol 1998; 9: 513-516.
52. Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-seg-ment elevation. Circulation 1999; 100: 1660-1666.
53. Kurita T, Shimizu W, Inagaki M, Suyama K, Taguchi A, Satomi K, et al. The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome. J Am Coll Cardiol 2002; 40: 330-334.
54. Belhassen B, Glick A, Viskin S. Effcacy of quinidine in high-risk patients with Brugada syndrome. Circulation 2004; 110: 1731-1737.
55. Nagase S, Kusano KF, Morita H, Fujimoto Y, Kakishita M, Nakamura K, et al. Epicardial electrogram of the right ventricular outfow tract in patients with the Brugada syndrome: Using the epicardial lead. J Am Coll Cardiol 2002; 39: 1992-1995.
56. Coronel R, Casini S, Koopmann TT, Wilms-Schopman FJ, Verkerk AO, de Groot JR, et al. Right ventricular fbrosis and conduction delay in a patient with clinical signs of Brugada syndrome: A combined electrophysiological, genetic, histopathologic, and computational study. Circulation 2005; 112: 2769-2777.
57. Meregalli PG, Wilde AAM, Tan HL. Pathophysiological mechanisms of Brugada syndrome: Depolarization disorder, repolariza-tion disorder, or more? Cardiovasc Res 2005, 67: 367-378.
58. Frustaci A, Priori SG, Pieroni M, Chimenti C, Napolitano C, Rivolta I, et al. Cardiac histological substrate in patients with clinical phe-notype of Brugada syndrome. Circulation 2005; 112: 3680-3687.
59. Postema PG, van Dessel PF, Kors JA, Linnenbank AC, van Herpen G, Ritsema van Eck HJ, et al. Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajma-line provocation. J Am Coll Cardiol 2010; 55: 789-797.
60. Eckardt L, Bruns HJ, Paul M, Kirchhof P, Schulze-Bahr E, Wichter T, et al. Body surface area of ST elevation and the presence of late potentials correlate to the inducibility of ventricular tachyarrhyth-mias in Brugada syndrome. J Cardiovasc Electrophysiol 2002; 13: 742-749.
61. Takami M, Ikeda T, Enjoji Y, Sugi K. Relationship between ST-segment morphology and conduction disturbances detected by signal-averaged electrocardiography in Brugada syndrome. Ann Non-invasive Electrocardiol 2003; 8: 30-36.
62. Tukkie R, Sogaard P, Vleugels J, de Groot IKLM, Wilde AAM, Tan HL. Delay in right ventricular activation contributes to Brugada syndrome. Circulation 2004; 109: 1272-1277.
63. Rouzet F, Algalarrondo V, Burg S, Nassar P, Sarda-Mantel L, Aouate P, et al. Contraction delay of the RV outfow tract in patients with Brugada syndrome is dependent on the spontaneous ST-segment elevation pattern. Heart Rhythm 2011; 8: 1905-1912.
64. Postema PG, van Dessel PF, de Bakker JMT, Dekker LR, Linnenbank AC, Hoogendijk MG, et al. Slow and discontinuous conduction conspire in Brugada syndrome: A right ventricular mapping and stimulation study. Circ Arrhythm Electrophysiol 2008; 1: 379-386.
65. Lambiase PD, Ahmed AK, Ciaccio EJ, Brugada R, Lizotte E, Chaubey S, et al. High-density substrate mapping in Brugada syndrome: Combined role of conduction and repolarization heterogeneities in arrhythmogenesis. Circulation 2009; 120: 106-117, 1-4.
66. Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S. Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 1996; 27: 1061-1070.
67. Tanaka H, Kinoshita O, Uchikawa S, Kasai H, Nakamura M, Izawa A, et al. Successful prevention of recurrent ventricular fibrillation by intravenous isoproterenol in a patient with Brugada syndrome. Pacing Clin Electrophysiol 2001; 24: 1293-1294.
68. Kasanuki H, Ohnishi S, Ohtuka M, Matsuda N, Nirei T, Isogai R, et al. Idiopathic ventricular fbrillation induced with vagal activity in patients without obvious heart disease. Circulation 1997; 95: 2277-2285.
69. Abe A, Kobayashi K, Yuzawa H, Sato H, Fukunaga S, Fujino T, et al. Comparison of late potentials for 24 hours between Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy using a novel signal-averaging system based on Holter ECG. Circ Ar-rhythm Electrophysiol 2012; 5: 789-795.
70. Krittayaphong R, Veerakul G, Bhuripanyo K, Jirasirirojanakorn K, Nademanee K. Heart rate variability in patients with sudden unexpected cardiac arrest in Thailand. Am J Cardiol 2003; 91: 77-81.
71. Nimannnit S, Malasit P, Chaovakul V, Susaengrat W, Vasuvattakul S, Nilwaranangkur S. Pathogenesis of unexplained nocturnal death and endemic distal renal tubular acidosis. Lancet 1991; 338: 930-932.
72. Andres R, Cader G, Goldman P, Zeirler K. Net potassium movement between resting muscle and plasma in man in the basal state and during the night. J Clin Invest 1957; 36: 723-729.
73. Araki J, Konno T, Itoh H, Ino H, Shimizu M. Brugada syndrome with ventricular tachycardia and fbrillation related to hypokalemia. Circ J 2003; 67: 93-95.
74. Nogami A, Nakao M, Kubota S, Sugiyasu A, Doi H, Yokoyama K, et al. Enhancement of J-ST-segment elevation by the glucose and insulin test in Brugada syndrome. Pacing Clin Electrophysiol 2003; 26: 332-337.
75. Dumaine R, Towbin JA, Brugada P, Vatta M, Nesterenko VV, Nesterenko DV, et al. Ionic mechanisms responsible for the elec-trocardiographic phenotype of the Brugada syndrome are temperature dependent. Circ Res 1999; 85: 803-809.
76. Antzelevitch C, Brugada R. Fever and the Brugada syndrome. Pacing Clin Electrophysiol 2002; 25: 1537-1539.
77. Morita H, Nagase S, Kusano K, Ohe T. Spontaneous T wave alter-nans and premature ventricular contractions during febrile illness in a patient with Brugada syndrome. J Cardiovasc Electrophysiol 2002; 13: 816-818.
78. Saura D, Garcia-Alberola A, Carrillo P, Pascual D, Martinez-Sanchez J, Valdes M. Brugada-like electrocardiographic pattern induced by fever. Pacing Clin Electrophysiol 2002; 25: 856-859.
79. Porres JM, Brugada J, Urbistondo V, Garcia F, Reviejo K, Marco P. Fever unmasking the Brugada syndrome. Pacing Clin Electro-physiol 2002; 25: 1646-1648.
80. Kum LCC, Fung JWH, Sanderson JE. Brugada syndrome unmasked by febrile illness. Pacing Clin Electrophysiol 2002; 25: 1660-1661.
81. Muggenthaler M, Behr ER. Brugada syndrome and atrial fbrilla-tion: Pathophysiology and genetics. Europace 2011; 13: 913-915.
82. Letsas KP, Sacher F, Probst V, Weber R, Knecht S, Kalusche D, et al. Prevalence of early repolarization pattern in inferolateral leads in patients with Brugada syndrome. Heart Rhythm 2008; 5: 1685-1689.
83. Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, et al. A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease. Cardiovasc Res 2002; 53: 348-354.
84. Chinushi M, Kuroe Y, Ito E, Tagawa M, Aizawa Y. Vasospastic angina accompanied by Brugada-type electrocardiographic abnormalities. J Cardiovasc Electrophysiol 2001; 12: 108-111.
85. Brugada J, Brugada R, Brugada P. Electrophysiologic testing predicts events in Brugada syndrome patients. Heart Rhythm 2011; 8: 1595-1597.
86. Wilde AA, Viskin S. EP testing does not predict cardiac events in Brugada syndrome. Heart Rhythm 2011; 8: 1598-1600.
87. Morita H, Kusano KF, Miura D, Nagase S, Nakamura K, Morita ST, et al. Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome. Circulation 2008; 118: 1697-1704.
88. Makimoto H, Nakagawa E, Takaki H, Yamada Y, Okamura H, Noda T, et al. Augmented ST-segment elevation during recovery from exercise predicts cardiac events in patients with Brugada syndrome. J Am Coll Cardiol 2010; 56: 1576-1584.
89. Amin AS, de Groot EAA, Ruijter JM, Wilde AAM, Tan HL. Exercise-induced ECG changes in Brugada syndrome. Circ Arrhythm Electrophysiol 2009; 2: 531-539.
90. Huang Z, Patel C, Li W, Xie Q, Wu R, Zhang L, et al. Role of signal-averaged electrocardiograms in arrhythmic risk stratifcation of patients with Brugada syndrome: A prospective study. Heart Rhythm 2009; 6: 1156-1162.
91. Postema PG, Wolpert C, Amin AS, Probst V, Borggrefe M, Roden DM, et al. Drugs and Brugada syndrome patients: Review of the literature, recommendations, and an up-to-date website (www. brugadadrugs.org). Heart Rhythm 2009; 6: 1335-1341.
92. Hermida JS, Denjoy I, Clerc J, Extramiana F, Jarry G, Milliez P, et al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Car-diol 2004; 43: 1853-1860.
93. Mizusawa Y, Sakurada H, Nishizaki M, Hiraoka M. Effects of low-dose quinidine on ventricular tachyarrhythmias in patients with Brugada syndrome: Low-dose quinidine therapy as an adjunctive treatment. J Cardiovasc Pharmacol 2006; 47: 359-364.
94. Viskin S, Antzelevitch C, Márquez MF, Belhassen B. Quinidine: A valuable medication joins the list of "endangered species". Euro-pace 2007; 9: 1105-1106.
95. Ohgo T, Okamura H, Noda T, Satomi K, Suyama K, Kurita T, et al. Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fbrillation. Heart Rhythm 2007; 4: 695-700.
96. Nademanee K, Veerakul G, Mower M, Likittanasombat K, Krittayaphong R, Bhuripanyo K, et al. Defbrillator versus beta-blockers for unexplained death in Thailand (DEBUT): A randomized clinical trial. Circulation 2003; 107: 2221-2226.
97. Sacher F, Probst V, Iesaka Y, Jacon P, Laborderie J, Mizon-Gerard F, et al. Outcome after implantation of a cardioverter defbrillator in patients with Brugada syndrome: A multicenter study. Circulation 2006; 114: 2317-2324.
98. Sarkozy A, Boussy T, Kourgiannides G, Chierchia GB, Richter S, De Potter T, et al. Long-term follow-up of primary prophylactic implantable cardioverter-defbrillator therapy in Brugada syndrome. Eur Heart J 2007; 28: 334-344.
99. Steven D, Roberts-Thomson KC, Inada K, Seiler J, Koplan BA, Tedrow UB, et al. Long-term follow-up in patients with presumptive Brugada syndrome treated with implanted defbrillators. J Car-diovasc Electrophysiol 2011; 22: 1115-1119.
100. Cappato R, Smith WM, Hood MA, Crozier IG, Jordaens L, Spitzer SG, et al. Subcutaneous chronic implantable defbrillation systems in humans. J interventional cardiac Electrophysiol 2012; 34: 325-332.
101. Haïssaguerre M, Extramiana F, Hocini M, Cauchemez B, Jaïs P, Cabrera JA, et al. Mapping and ablation of ventricular fbrillation associated with long-QT and Brugada syndromes. Circulation 2003; 108: 925-928.
102. Nakagawa E, Takagi M, Tatsumi H, Yoshiyama M. Successful radiofrequency catheter ablation for electrical storm of ventricular fbrillation in a patient with Brugada syndrome. Circ J 2008; 72: 1025-1029.
103. Darmon JP, Bettouche S, Deswardt P, Tiger F, Ricard P, Bernasconi F, et al. Radiofrequency ablation of ventricular fbrillation and multiple right and left atrial tachycardia in a patient with Brugada syndrome. J Interv Card Electrophysiol 2004; 11: 205-209.