Gender Differences in Clinical Manifestations of Brugada Syndrome

Journal of the American College of Cardiology

Volumn 52, Issue 19, 2008, Pages 1567-1573

  Benito, Begoña ^a   Sarkozy, Andrea ^b   Mont, Lluis ^a   Henkens, Stephan ^b   Berruezo, Antonio ^a   Tamborero, David ^a   Arzamendi, Dabit ^a   Berne, Paola ^a   Brugada, Ramon ^c   Brugada, Pedro ^b   Brugada, Josep ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^c MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Brugada syndrome; gender; sudden cardiac death

Indexed keywords

SODIUM CHANNEL BLOCKING AGENT;

ADULT; ARTICLE; BRUGADA SYNDROME; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW UP; HEART VENTRICLE FIBRILLATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; QT INTERVAL; SEX DIFFERENCE; ST SEGMENT ELEVATION; SUDDEN DEATH; SYNCOPE;

ADULT; AGE OF ONSET; BRUGADA SYNDROME; COHORT STUDIES; COMBINED MODALITY THERAPY; CONFIDENCE INTERVALS; DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDIES; QUEBEC; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; SURVIVAL ANALYSIS;

EID: 54849439353     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.07.052     Document Type: Article

References (31)

1. Brugada P., and Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 20 (1992) 1391-1396
2. Chen Q., Kirsch G.E., Zhang D., et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 392 (1998) 293-296
3. Deschênes I., Baroudi G., Berthet M., et al. Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes. Cardiovasc Res 46 (2000) 55-65
4. Vatta M., Dumaine R., Antzelevitch C., et al. Novel mutations in domain I of SCN5A cause Brugada syndrome. Mol Genet Metab 75 (2002) 317-324
5. + current and causes inherited arrhythmias. Circulation 116 (2007) 2260-2268
6. Antzelevitch C. Brugada syndrome. Pacing Clin Electrophysiol 29 (2006) 1130-1159
7. Eckardt L. Gender differences in brugada syndrome. J Cardiovasc Electrophysiol 18 (2007) 422-424
8. Brugada J., Brugada R., Antzelevitch C., Towbin J., Nademanee K., and Brugada P. Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. Circulation 105 (2002) 73-78
9. Priori S.G., Napolitano C., Gasparini M., et al. Natural history of Brugada syndrome: insights for risk stratification and management. Circulation 105 (2002) 1342-1347
10. Brugada J., Brugada R., and Brugada P. Determinants of sudden cardiac death in individuals with the electrocardiographic pattern of Brugada syndrome and no previous cardiac arrest. Circulation 108 (2003) 3092-3096
11. Eckardt L., Probst V., Smits J.P.P., et al. Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome. Circulation 111 (2005) 257-263
12. Gehi A., Duong T., Metz L., Gomes J., and Mehta D. Risk stratification of individuals with the brugada electrocardiogram: a meta-analysis. J Cardiovasc Electrophysiol 17 (2006) 577-583
13. Vatta M., Dumaine R., Varghese G., et al. Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome. Hum Mol Genet 11 (2002) 337-345
14. Di Diego J.M., Cordeiro J.M., Goodrow R.J., et al. Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males. Circulation 106 (2002) 2004-2011
15. Matsuo K., Akahoshi M., Seto S., and Yano K. Disappearance of the Brugada-type electrocardiogram after surgical castration: a role for testosterone and an explanation for the male preponderance. Pacing Clin Electrophysiol 26 (2003) 1551-1553
16. Shimizu W., Matsuo K., Kokubo Y., et al. Sex hormone and gender difference-role of testosterone on male predominance in Brugada syndrome. J Cardiovasc Electrophysiol 18 (2007) 415-421
17. Antzelevitch C., Brugada P., Borggrefe M., et al. Brugada syndrome: report of the Second Consensus Conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 111 (2005) 659-670
18. Smits J.P.P., Eckardt L., Probst V., et al. Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients. J Am Coll Cardiol 40 (2002) 350-356
19. Yokokawa M., Noda T., Okamura H., et al. Comparison of long-term follow-up of electrocardiographic features in Brugada syndrome between the SCN5A-positive probands and the SCN5A-negative probands. Am J Cardiol 100 (2007) 649-655
20. Hong K., Berruezo-Sanchez A., Poungvarin N., et al. Phenotypic characterization of a large European family with Brugada syndrome displaying a sudden unexpected death syndrome mutation in SCN5A: female predominance in the signs and symptoms of the disease. J Cardiovasc Electrophysiol 15 (2004) 64-69
21. Verkerk A.O., Wilders R., de Geringel W., and Tan H.L. Cellular basis of sex disparities in human cardiac electrophysiology. Acta Physiol 187 (2006) 459-477
22. Veltmann C., Schimpf R., Echternach C., et al. A prospective study on spontaneous fluctuations between diagnostic and non-diagnostic ECGs in Brugada syndrome: implications for correct phenotyping and risk stratification. Eur Heart J 27 (2006) 2544-2552
23. Kyndt F., Probst V., Potet F., et al. Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family. Circulation 104 (2001) 3081-3086
24. Fish J., and Antzelevitch C. Cellular and ionic basis for the sex-related difference in the manifestation of the Brugada syndrome and progressive conduction disease phenotypes. J Electrocardiol 36 (2003) 173-179
25. Liu X.K., Katchman A., Drici M.D., et al. Gender difference in the cycle length-dependent QT and potassium currents in rabbits. J Pharmacol Exp Ther 285 (1998) 672-679
26. Pham T., Robinson R., Danilo P.J., and Rosen M. Effects of gonadal steroids on gender-related differences in transmural dispersion of L-type calcium current. Cardiovasc Res 53 (2002) 752-762
27. James A.F., Choisy S.C., and Hancox J.C. Recent advances in understanding sex differences in cardiac repolarization. Prog Biophys Mol Biol 94 (2007) 265-319
28. Antzelevitch C. Androgens and male predominance of the Brugada syndrome phenotype. Pacing Clin Electrophysiol 26 (2003) 1429-1431
29. Song M., Helguera G., Eghbali M., et al. Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones. J Biol Chem 276 (2001) 31883-31890
30. Bai C.X., Kurokawa J., Tamagawa M., Nakaya H., and Furukawa T. Nontranscriptional regulation of cardiac repolarization currents by testosterone. Circulation 112 (2005) 1701-1710
31. Probst V., Denjoy I., Meregalli P.G., et al. Clinical aspects and prognosis of Brugada syndrome in children. Circulation 115 (2007) 2042-2048