A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease

Cardiovascular Research

Volumn 53, Issue 2, 2002, Pages 348-354

  Shirai, Nobumasa ^a   Makita, Naomasa ^a   Sasaki, Koji ^a   Yokoi, Hisataka ^a   Sakuma, Ichiro ^a   Sakurada, Harumizu ^b   Akai, Jun ^c   Kimura, Akinori ^c   Hiraoka, Masayasu ^c   Kitabatake, Akira ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN HIROO HOSPITAL   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Arrhythmia (mechanisms); Conduction (block); Na channel; Sudden death; Ventricular arrhythmias

Indexed keywords

SODIUM; SODIUM CHANNEL;

ARTICLE; BRUGADA SYNDROME; CHANNEL GATING; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ELECTRIC POTENTIAL; ELECTROCARDIOGRAM; HEART BUNDLE BRANCH BLOCK; HEART MUSCLE CONDUCTION DISTURBANCE; HEART VENTRICLE FIBRILLATION; HUMAN; HUMAN CELL; MAMMAL CELL; MUTATION; PATCH CLAMP; PHENOTYPE; PHYSICAL DISABILITY; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ARRHYTHMIA; BUNDLE-BRANCH BLOCK; CELL LINE; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HUMANS; ION CHANNEL GATING; MUTATION; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; SODIUM CHANNELS; SYNDROME;

EID: 0036164452     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00494-1     Document Type: Article

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