Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies

Heart Rhythm

Volumn 6, Issue 3, 2009, Pages 341-348

  Meregalli, Paola G ^a   Tan, Hanno L ^a   Probst, Vincent ^b,c,d   Koopmann, Tamara T ^a   Tanck, Michael W ^a   Bhuiyan, Zahurul A ^a   Sacher, Frederic ^e   Kyndt, Florence ^b,c,d,f   Schott, Jean Jacques ^b,c,d   Albuisson, J ^b,c,d,f   Mabo, Philippe ^g   Bezzina, Connie R ^a   Le Marec, Herve ^b,c,d   Wilde, Arthur A M ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b L INSTITUT DU THORAX   (France)

^c CNRS   (France)

^d UNIVERSITÉ DE NANTES   (France)

^e UNIVERSITÉ DE BORDEAUX   (France)

^f NANTES UNIVERSITY HOSPITAL   (France)

^g RENNES UNIVERSITY HOSPITAL   (France)

Author keywords

Arrhythmia; Brugada syndrome; Conduction disorders; Genetics

Indexed keywords

ADULT; ARTICLE; BRUGADA SYNDROME; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; FEMALE; FRAMESHIFT MUTATION; GENE; GENE MUTATION; HUMAN; INDEL MUTATION; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NONSENSE MUTATION; PHENOTYPE; PR INTERVAL; PRIORITY JOURNAL; PROGRESSIVE CARDIAC CONDUCTION DEFECT; QRS COMPLEX; SCN5A GENE; SODIUM CHANNELOPATHY; SYNCOPE;

ADULT; ARRHYTHMIAS, CARDIAC; BRUGADA SYNDROME; CODON, TERMINATOR; DEATH, SUDDEN, CARDIAC; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; MALE; MIDDLE AGED; MUSCLE PROTEINS; MUTATION; MUTATION, MISSENSE; PHENOTYPE; RISK ASSESSMENT; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 61349143781     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2008.11.009     Document Type: Article

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