Control of the immune system by oxysterols and cancer development

Current Opinion in Pharmacology

Volumn 12, Issue 6, 2012, Pages 729-735

  Traversari, Catia ^a   Russo, Vincenzo ^b  

^a MOLMED S P A   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR7; LIVER X RECEPTOR; OXYSTEROL;

ARTICLE; B LYMPHOCYTE; CANCER CELL; CANCER GROWTH; CANCER IMMUNOLOGY; CARCINOGENESIS; CELL FUNCTION; CELL PROLIFERATION; CELLULAR IMMUNITY; CHOLESTEROL METABOLISM; DISEASE ACTIVITY; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; TH1 CELL; TH17 CELL; TUMOR IMMUNITY;

EID: 84870546132     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2012.07.003     Document Type: Review

References (59)

1. X. Yang, K.A. Lamia, and R.m. Evans Nuclear receptors, metabolism, and the circadian clock Cold Spring Harb Symp Quant Biol 72 2007 387 394
2. N.Y. Kalaany, D.J. Mangelsdorf, and F.X.R. LXRs The Yin and Yang of cholesterol and fat metabolism Annu Rev Physiol 68 2006 159 191
3. N. Mitro, P.A. Mak, L. Vargas, C. Godio, E. Hampton, V. Molteni, A. Kreusch, and E. Saez The nuclear receptor LXR is a glucose sensor Nature 445 2007 219 223
4. J.J. Repa, and D.J. Mangelsdorf The role of orphan nuclear receptors in the regulation of cholesterol homeostasis Annu Rev Cell Dev Biol 16 2000 459 481
5. D.J. Peet, B.A. Janowski, and D.J. Mangelsdorf The LXRs: a new class of oxysterol receptors Curr Opin Genetics Dev 8 1998 571 575
6. I. Bjorkhem Do oxysterols control cholesterol homeostasis? J Clin Invest 110 2002 725 730
7. W.L. Smith, and R.C. Murphy Oxidized lipids formed non-enzymatically by reactive oxygen species J Biol Chem 283 2008 15513 15514
8. C.K. Glass, and M.G. Rosenfeld The coregulator exchange in transcriptional functions of nuclear receptors Genes Dev 14 2000 121 141
9. B.L. Wagner, A.F. Valledor, G. Shao, C.L. Daige, E.D. Bischoff, M. Petrowski, K. Jepsen, S.H. Baek, R.A. Heyman, and M.G. Rosenfeld Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of abca1 and srebp1 gene expression Mol Cell Biol 23 2003 5780 5789
10. V. Perissi, K. Jepsen, C.K. Glass, and M.G. Rosenfeld Deconstructing repression: evolving models of co-repressor action Nat Rev Genet 11 2010 109 123
11. T. Jakobsson, N. Venteclef, G. Toresson, A.E. Damdimopoulos, A. Ehrlund, X. Lou, S. Sanyal, K.R. Steffensen, J.A. Gustafsson, and E. Treuter GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus Mol Cell 34 2009 510 518
12. S.B. Joseph, A. Castrillo, B.A. Laffitte, D.J. Mangelsdorf, and P. Tontonoz Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nat Med 9 2003 213 219
13. C.K. Glass, and Saijo K Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells Nat Rev Immunol 10 2010 365 376
14. G. Pascual, A.L. Fong, S. Ogawa, A. Gamliel, A.C. Li, V. Perissi, D.W. Rose, T.M. Willson, M.G. Rosenfeld, and C.K. Glass A sumoylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma Nature 437 2005 759 763
15. S.B. Joseph, M.N. Bradley, A. Castrillo, K.W. Bruhn, P.A. Mak, L. Pei, J. Hogenesch, R.M. O'connell, G. Cheng, and E. Saez LXR-dependent gene expression is important for macrophage survival and the innate immune response Cell 119 2004 299 309
16. A.F. Valledor, L.C. Hsu, S. Ogawa, D. Sawka-Verhelle, M. Karin, and C.K. Glass Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis Proc Natl Acad Sci U S A 101 2004 17813 17818
17. K. Smoak, J. Madenspacher, S. Jeyaseelan, B. Williams, D. Dixon, K.R. Poch, J.A. Nick, G.S. Worthen, and M.B. Fessler Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense J Immunol 180 2008 3305 3312
18. H. Korf, S. Vander Beken, M. Romano, K.R. Steffensen, B. Stijlemans, J.A. Gustafsson, J. Grooten, and K. Huygen Liver X receptors contribute to the protective immune response against mycobacterium tuberculosis in mice J Clin Invest 119 2009 1626 1637
19. N. A-Gonzalez, S.J. Bensinger, C. Hong, S. Beceiro, M.N. Bradley, N. Zelcer, J. Deniz, C. Ramirez, M. Diaz, and G. Gallardo Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR Immunity 31 2009 245 258
20. L. Mukundan, J.I. Odegaard, C.R. Morel, J.E. Heredia, J.W. Mwangi, R.R. Ricardo-Gonzalez, Y.P. Goh, A.R. Eagle, S.E. Dunn, and J.U. Awakuni PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance Nat Med 15 2009 1266 1272
21. C. Hong, Y. Kidani, A.G. N-Gonzalez, T. Phung, A. Ito, X. Rong, K. Ericson, H. Mikkola, S.W. Beaven, and L.S. Miller Coordinate regulation of neutrophil homeostasis by liver X receptors in mice J Clin Invest 122 2012 337 347
22. M.A. Stark, Y. Huo, T.L. Burcin, M.A. Morris, T.S. Olson, and K. Ley Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17 Immunity 22 2005 285 294
23. R. Geyeregger, M. Zeyda, W. Bauer, E. Kriehuber, M.D. Saemann, G.J. Zlabinger, D. Maurer, and T.M. Stulnig Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin Blood 109 2007 4288 4295
24. D. Torocsik, M. Barath, S. Benko, L. Szeles, B. Dezso, S. Poliska, Z. Hegyi, L. Homolya, I. Szatmari, and A. Lanyi Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli J Immunol 184 2010 5456 5465
25. E.J. Villablanca, L. Raccosta, D. Zhou, R. Fontana, D. Maggioni, A. Negro, F. Sanvito, M. Ponzoni, B. Valentinis, and M. Bregni Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses Nat Med 16 2010 98 105
26. R.M. Steinman Dendritic cells: understanding immunogenicity Eur J Immunol 37 Suppl. 1 2007 S53 S60
27. Q. Huang, D. Liu, P. Majewski, L.C. Schulte, J.m. Korn, R.a. Young, E.S. Lander, and N. Hacohen The plasticity of dendritic cell responses to pathogens and their components Science 294 2001 870 875
28. F. Le Naour, L. Hohenkirk, A. Grolleau, D.e. Misek, P. Lescure, J.D. Geiger, S. Hanash, and L. Beretta Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics J Biol Chem 276 2001 17920 17931
29. R.M. Steinman, and J. Banchereau Taking dendritic cells into medicine Nature 449 2007 419 426
30. R.M. Steinman Lasker basic medical research award. Dendritic cells: versatile controllers of the immune system Nat Med 13 2007 1155 1159
31. L. Ohl, M. Mohaupt, N. Czeloth, G. Hintzen, Z. Kiafard, J. Zwirner, T. Blankenstein, G. Henning, and R. Forster CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions Immunity 21 2004 279 288
32. G.J. Randolph, J. Ochando, and S. Partida-Sanchez Migration of dendritic cell subsets and their precursors Annu Rev Immunol 26 2008 293 316
33. F. Sallusto, and A. Lanzavecchia Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression Immunol Rev 177 2000 134 140
34. T.M. Hanley, W. Blay Puryear, S. Gummuluru, and G.A. Viglianti PPAR-gamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection PLoS Pathog 6 2010 E1000981
35. J.E. Feig, I. Pineda-Torra, M. Sanson, M.N. Bradley, Y. Vengrenyuk, D. Bogunovic, E.L. Gautier, D. Rubinstein, C. Hong, and J. Liu LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression J Clin Invest 120 2010 4415 4424
36. A. Nencioni, F. Grunebach, A. Zobywlaski, C. Denzlinger, W. Brugger, and P. Brossart Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma J Immunol 169 2002 1228 1235
37. E.J. Villablanca, D. Zhou, B. Valentinis, A. Negro, L. Raccosta, L. Mauri, A. Prinetti, S. Sonnino, C. Bordignon, and C. Traversari Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo J Leukoc Biol 84 2008 871 879
38. S.J. Bensinger, M.N. Bradley, S.B. Joseph, N. Zelcer, E.m. Janssen, M.A. Hausner, R. Shih, J.S. Parks, P.A. Edwards, and B.D. Jamieson LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell 134 2008 97 111
39. R. Geyeregger, M. Shehata, M. Zeyda, F.W. Kiefer, K.M. Stuhlmeier, E. Porpaczy, G.J. Zlabinger, U. Jager, and T.M. Stulnig Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes J Leukoc Biol 86 2009 1039 1048
40. J. Xu, G. Wagoner, J.C. Douglas, and P.D. Drew Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity J Leukoc Biol 86 2009 401 409
41. G. Cui, X. Qin, L. WU, Y. Zhang, X. Sheng, Q. Yu, H. Sheng, B. Xi, J.Z. Zhang, and Y.Q. Zang Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation J Clin Invest 121 2011 658 670
42. F.J. Quintana, A.S. Basso, A.H. Iglesias, T. Korn, M.F. Farez, E. Bettelli, M. Caccamo, M. Oukka, and H.L. Weiner Control of T(Reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor Nature 453 2008 65 71
43. M. Veldhoen, K. Hirota, A.M. Westendorf, J. Buer, L. Dumoutier, J.C. Renauld, and B. Stockinger The aryl hydrocarbon receptor links Th17-cell-mediated autoimmunity to environmental toxins Nature 453 2008 106 109
44. D. Walcher, A. Kummel, B. Kehrle, H. Bach, M. Grub, R. Durst, V. Hombach, and N. Marx LXR activation reduces proinflammatory cytokine expression in human CD4-positive lymphocytes Arterioscler Thromb Vasc Biol 26 2006 1022 1028
45. G. Heine, A. Dahten, K. Hilt, D. Ernst, M. Milovanovic, B. Hartmann, and M. Worm Liver X receptors control ige expression in B cells J Immunol 182 2009 5276 5282
46. J.P. Pereira, L.M. Kelly, Y. Xu, and J.G. Cyster Ebi2 mediates B cell segregation between the outer and centre follicle Nature 460 2009 1122 1126
47. S. Hannedouche, J. Zhang, T. Yi, W. Shen, D. Nguyen, J.P. Pereira, D. Guerini, B.U. Baumgarten, S. Roggo, and B. Wen Oxysterols direct immune cell migration via EBI2 Nature 475 2011 524 527
48. C. Liu, X.V. Yang, J. Wu, C. Kuei, N.S. Mani, L. Zhang, J. Yu, S.W. Sutton, N. Qin, and H. Banie Oxysterols direct B-cell migration through EBI2 Nature 475 2011 519 523
49. B.A. Janowski, P.J. Willy, T.R. Devi, J.R. Falck, and D.J. Mangelsdorf An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha Nature 383 1996 728 731
50. J.M. Lehmann, S.A. Kliewer, L.B. Moore, T.A. Smith-Oliver, B.B. Oliver, J.L. Su, S.S. Sundseth, D.A. Winegar, D.E. Blanchard, and T.A. Spencer Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway J Biol Chem 272 1997 3137 3140
51. L.P. Sun, J. Seemann, J.L. Goldstein, and M.S. Brown Sterol-regulated transport of srebps from endoplasmic reticulum to golgi: insig renders sorting signal in scap inaccessible to COPII proteins Proc Natl Acad Sci U S A 104 2007 6519 6526
52. S. Nachtergaele, L.K. Mydock, K. Krishnan, J. Rammohan, P.H. Schlesinger, D.F. Covey, and R. Rohatgi Oxysterols are allosteric activators of the oncoprotein smoothened Nat Chem Biol 8 2012 211 220
53. D. Guo, F. Reinitz, M. Youssef, C. Hong, D. Nathanson, D. Akhavan, D. Kuga, A.N. Amzajerdi, H. Soto, and S. Zhu An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway Cancer Discov 1 2011 442 456
54. J. Fukuchi, J.M. Kokontis, R.A. Hiipakka, C.P. Chuu, and S. Liao Antiproliferative effect of liver X receptor agonists on lncap human prostate cancer cells Cancer Res 64 2004 7686 7689
55. C.P. Chuu, and H.P. Lin Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines Anticancer Res 30 2010 3643 3648
56. C.P. Chuu, R.A. Hiipakka, J.M. Kokontis, J. Fukuchi, R.Y. Chen, and S. Liao Inhibition of tumor growth and progression of lncap prostate cancer cells in athymic mice by androgen and liver X receptor agonist Cancer Res 66 2006 6482 6486
57. C.P. Chuu Modulation of liver X receptor signaling as a prevention and therapy for colon cancer Med Hypotheses 76 2011 697 699
58. H. Fuda, N.B. Javitt, K. Mitamura, S. Ikegawa, and C.A. Strott Oxysterols are substrates for cholesterol sulfotransferase J Lipid Res 48 2007 1343 1352
59. C.A. Strott Sulfonation and molecular action Endocr Rev 23 2002 703 732