Narcoleptic episodes in orexin-deficient mice are increased by both attractive and aversive odors

Behavioural Brain Research

Volumn 222, Issue 2, 2011, Pages 397-400

  Morawska, Marta ^a,b   Buchi, Mélanie ^a   Fendt, Markus ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Cataplexy; Emotion; Narcolepsy; Odors; Orexin

Indexed keywords

OREXIN;

ANIMAL EXPERIMENT; ARTICLE; AVERSION; CATAPLEXY; CONTROLLED STUDY; COYOTE; FEMALE; MOUSE; MOUSE STRAIN; NARCOLEPSY; NONHUMAN; OLFACTORY DISCRIMINATION; PRIORITY JOURNAL; PROTEIN DEPLETION; SENSORY STIMULATION; SLEEP PATTERN; URINALYSIS;

ANIMALS; COYOTES; DISEASE MODELS, ANIMAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NARCOLEPSY; NEUROPEPTIDES; ODORS; OLFACTORY PERCEPTION;

EID: 79955972741     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.04.005     Document Type: Article

References (20)

1. Scammell T.E. The neurobiology, diagnosis, and treatment of narcolepsy. Ann Neurol 2003, 53:154-166.
2. Nishino S. Narcolepsy: pathophysiology and pharmacology. J Clin Psychiatry 2007, 68:9-15.
3. Anic-Labat S., Guilleminault C., Kraemer H.C., Meehan J., Arrigoni J., Mignot E. Validation of a cataplexy questionnaire in 983 sleep-disorders patients. Sleep 1999, 22:77-87.
4. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000, 27:469-474.
5. Matsuki T., Sakurai T. Orexins and orexin receptors: from molecules to integrative physiology. Results Probl Cell Differ 2008, 46:46-55.
6. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T.E., Lee C., et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999, 98:409-412.
7. Scammell T.E., Willie J.T., Guilleminault C., Siegel J.M. A consensus definition of cataplexy in mouse models of narcolepsy. Sleep 2009, 32:111-116.
8. Willie J.T., Chemelli R.M., Sinton C.M., Tokita S., Williams S.C., Kisanuki Y.Y., et al. Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes. Neuron 2003, 38:715-730.
9. Espana R.A., McCormack S.L., Mochizuki T., Scammell T.E. Running promotes wakefulness and increases cataplexy in orexin knockout mice. Sleep 2007, 30:1417-1425.
10. Clark E.L., Baumann C.R., Cano G., Scammell T.E., Mochizuki T. Feeding-elicited cataplexy in orexin knockout mice. Neuroscience 2009, 161:970-977.
11. Apfelbach R., Blanchard C.D., Blanchard R.J., Hayes R.A., McGregor I.S. The effects of predator odors in mammalian prey species: a review of field and laboratory studies. Neurosci Biobehav Rev 2005, 29:1123-1144.
12. Fendt M. Exposure to urine of canids and felids but not of herbivores induces defensive behavior in laboratory rats. J Chem Ecol 2006, 32:2617-2627.
13. Roullet F.I., Wohr M., Crawley J.N. Female urine-induced male mice ultrasonic vocalizations, but not scent-marking, is modulated by social experience. Behav Brain Res 2011, 216:19-28.
14. Kobayakawa K., Kobayakawa R., Matsumoto H., Oka Y., Imai T., Ikawa M., et al. Innate versus learned odour processing in the mouse olfactory bulb. Nature 2007, 450:503-508.
15. Lin J.S., Dauvilliers Y., Arnulf I., Bastuji H., Anaclet C., Parmentier R., et al. An inverse agonist of the histamine H-3 receptor improves wakefulness in narcolepsy: Studies in orexin(-/-) mice and patients. Neurobiol Dis 2008, 30:74-83.
16. Hohoff C. Anxiety in mice and men: a comparison. J Neural Transm 2009, 116:679-687.
17. Berridge K.C. Pleasures of the brain. Brain Cogn 2003, 52:106-128.
18. Blanchard D.C., Griebel G., Blanchard R.J. Conditioning and residual emotionality effects of predator stimuli: some reflections on stress and emotion. Prog Neuropsychopharmacol Biol Psychiatry 2003, 27:1177-1185.
19. Dielenberg R.A., McGregor I.S. Defensive behavior in rats towards predatory odors: a review. Neurosci Biobehav Rev 2001, 25:597-609.
20. Malkesman O., Scattoni M.L., Paredes D., Tragon T., Pearson B., Shaltiel G., et al. The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents. Biol Psychiatry 2010, 67:864-871.