Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia

Neuropsychopharmacology

Volumn 37, Issue 5, 2012, Pages 1224-1233

  Bettica, Paolo ^a   Squassante, Lisa ^a   Groeger, John A ^c,d   Gennery, Brian ^b   Winsky Sommerer, Raphaelle ^c   Dijk, Derk Jan ^b,c  

^a GSK   (Italy)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

circadian; GABA9; hypnotics; hypocretin; insomnia; SB 649868

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; HYPNOTIC AGENT; PLACEBO; SB 649868; ZOLPIDEM;

ADULT; ARTICLE; ATTENTION DISTURBANCE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ELECTROENCEPHALOGRAM; FEMALE; HALLUCINATION; HEADACHE; HUMAN; INSOMNIA; MALE; MEMORY CONSOLIDATION; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REM SLEEP; SINGLE DRUG DOSE; SLEEP PARAMETERS; SLEEP TIME; SLOW WAVE SLEEP; SOMNOLENCE; TRAFFIC NOISE;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; BENZOFURANS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ELECTROENCEPHALOGRAPHY; GABA-A RECEPTOR AGONISTS; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYSOMNOGRAPHY; PSYCHOMOTOR PERFORMANCE; PYRIDINES; QUESTIONNAIRES; REACTION TIME; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SLEEP INITIATION AND MAINTENANCE DISORDERS; SLEEP, REM; THIAZOLES; WAKEFULNESS; YOUNG ADULT;

EID: 84858341874     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.310     Document Type: Article

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