Do energy drinks contain active components other than caffeine?

Nutrition Reviews

Volumn 70, Issue 12, 2012, Pages 730-744

  McLellan, Tom M ^a   Lieberman, Harris R ^b  

^a TM McLellan Research Inc   (Canada)

^b U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

Guaran ; Physical and cognitive performance; Red Bull; Taurine

Indexed keywords

ARGININE; CAFFEINE; CARNITINE; CYANOCOBALAMIN; GINSENG EXTRACT; GLUCOSE; GLUCURONOLACTONE; GLYCOGEN; GUARANA EXTRACT; HERBACEOUS AGENT; NICOTINAMIDE; PANTOTHENIC ACID; PLACEBO; PYRIDOXINE; RIBOFLAVIN; SUGAR; TAURINE; VITAMIN;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ARTICLE; BLOOD BRAIN BARRIER; CARDIOVASCULAR RISK; COGNITION; DIET SUPPLEMENTATION; ENERGY DRINK; GENE EXPRESSION; GLYCOGEN MUSCLE LEVEL; HEART OUTPUT; HEART RATE; HERBAL MEDICINE; HUMAN; ILEX PARAGUARIENSIS; LOCOMOTION; MENTAL PERFORMANCE; MOTOR PERFORMANCE; NEUROTRANSMISSION; NONHUMAN; NUTRITIONAL ASSESSMENT; NUTRITIONAL HEALTH; OXYGEN CONSUMPTION; TREADMILL EXERCISE; VASCULAR SMOOTH MUSCLE;

BEVERAGES; CAFFEINE; DIETARY SUCROSE; HUMANS; MENTAL PROCESSES; PAULLINIA; PHYSICAL ENDURANCE; PLANT EXTRACTS; PSYCHOMOTOR PERFORMANCE;

PANAX GINSENG; PAULLINIA CUPANA;

EID: 84870515611     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2012.00525.x     Document Type: Article

References (132)

1. Klineman J. Channel check: What's hot - and what's not - in stores now. Beverage Spectrum. New York: BJ Nathanson; December 2010:12-13.
2. Heckman MA, Sherry K, Gonzalez De Mejia EG. Energy drinks: An assessment of their market size, consumer demographics, ingredient profile, functionality, and regulations in the United States. Compr Rev Food Sci Food Saf. 2010;9:303-317.
3. U.S Food and Drug Administration. Overview of dietary supplements. US Food and Drug Administration. 2009; Available at: http://www.fda.gov/Food/DietarySupplements/ConsumerInformation/ucm191930.htm. Accessed 20 May 2011.
4. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: The possible role of caffeine, taurine, and inositol. Can J Psychiatry. 2001;46:454-455.
5. Berger AJ, Alford K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks." Med J Aust. 2009;190:41-43.
6. Worthley MI, Prabhu A, Sciscio PD, etal. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med. 2010;123:184-187.
7. Holmes RO, Tavee J. Vasospasm and stroke attributable to ephedra-free xenadrine: A case report. Mil Med. 2008;173:708-710.
8. Baghkhani L, Jafari M. Cardiovascular adverse reactions associated with guarana: Is there a causal effect? J Herb Pharmacother. 2002;2:57-61.
9. Iyadurai SJP, Chung SS. New-onset seizures in adults: Possible association with consumption of popular energy drinks. Epilepsy Behav. 2007;10:504-508.
10. Nasir JM, Durning SJ, Ferguson M, etal. Exercise-induced syncope associated with qt prolongation and ephedra-free xenadrine. Mayo Clin Proc. 2004;79:1059-1062.
11. Malinauskas BM, Aeby VG, Overton FRF, etal. A survey of energy drink consumption patterns among college students. Nutr J. 2007;6:35-41.
12. Oteri A, Salvo F, Caputi AP, etal. Intake of energy drinks in association with alcoholic beverages in a cohort of students of the School of Medicine of the University of Messina. Alcohol Clin Exp Res. 2007;31:1677-1680.
13. O'Brien MC, McCoy TP, Rhodes SD, etal. Caffeinated cocktails: Energy drink consumption, high-risk drinking, and alcohol-related consequences among college students. Acad Emerg Med. 2008;15:1-8.
14. Ferreira SE, Quadros IMH, Trindade AA, etal. Can energy drinks reduce the depressor effect of ethanol? An experimental study in mice. Physiol Behav. 2004;82:841-847.
15. Ferreira SE, de Mello MT, Pompeia S, etal. Effects of energy drink ingestion on alcohol intoxication. Alcohol Clin Exp Res. 2006;30:598-605.
16. Liguori A, Robinson JH. Caffeine antagonism of alcohol-induced driving impairment. Drug Alcohol Depend. 2001;63:123-129.
17. Mackay M, Tiplady B, Scholey AB. Interactions between alcohol and caffeine in relation to psychomotor speed. Hum Psychopharmacol. 2002;17:151-156.
18. Seifert SM, Schaechter JL, Hershorin ER, etal. Health effects of energy drinks on children, adolescents, and young adults. Pediatrics. 2011;127:511-528.
19. Babu KM, Church RJ, Lewander W. Energy drinks: The new eye-opener for adolescents. Clin Pediatr Emerg Med. 2008;9:35-42.
20. Clauson KA, Shields KM, McQueen CE, etal. Safety issues associated with commercially available energy drinks. Pharm Today. 2008;14:52-64.
21. Duchan E, Patel ND, Feucht C. Energy drinks: A review of use and safety. Phys Sportsmed. 2010;38:171-179.
22. Finnegan D. The health effects of stimulant drinks. Nutr Bull. 2003;28:147-155.
23. Lee SW, Chung SS. A review of the effects of vitamins and other dietary supplements on seizure activity. Epilepsy Behav. 2010;18:139-150.
24. Higgins JP, Tuttle TD, Higgins CL. Energy beverages: Content and safety. Mayo Clin Proc. 2010;85:1033-1041.
25. Spinella M. Herbal medicines and epilepsy: The potential for benefit and adverse events. Epilepsy Behav. 2001;2:524-532.
26. Lieberman HR. Cognitive methods for assessing mental energy. Nutr Neurosci. 2007;10:229-242.
27. Lieberman HR. Mental energy: Assessing the cognition dimension. Nutr Rev. 2006;64:(Suppl):S10-S13.
28. Lieberman HR. Mental energy and fatigue. Science and the consumer. In: Kanarek R, Lieberman H, eds. Diet, Brain, Behavior: Practical Implications. Boca Raton, FL: CRC Press; 2011:1-6.
29. O'Connor PJ. Evaluation of four highly cited energy and fatigue mood measures. J Psychosom Res. 2004;57:435-441.
30. Lieberman HR. The effects of ginseng, ephedrine, and caffeine on cognitive performance, mood and energy. Nutr Rev. 2001;59:91-102.
31. Klepacki B. Energy drinks: A review article. Strength Cond J. 2010;32:37-41.
32. Hoffmann JR. Caffeine and energy drinks. Strength Cond J. 2010;32:15-20.
33. Lieberman HR. Nutrition, brain function and cognitive performance. Appetite. 2003;40:245-254.
34. Sokmen B, Armstrong LE, Kraemer WJ, etal. Caffeine use in sports: Considerations for the athlete. J Strength Cond Res. 2008;22:978-986.
35. Glade MJ. Caffeine - not just a stimulant. Nutrition. 2010;26:932-938.
36. Ganio MS, Klau JF, Casa DJ, etal. Effect of caffeine on sport-specific endurance performance: A systematic review. J Strength Cond Res. 2009;23:315-324.
37. Reissig CJ, Strain EC, Griffiths RR. Caffeinated energy drinks - a growing problem. Drug Alcohol Depend. 2009;99:1-10.
38. Lieberman HR, Carvey CE, Thompson LA. Caffeine. In: Coates P, ed. Encyclopedia of Dietary Supplements. New York: Informa Healthcare USA, Inc.; 2010:94-104.
39. Smith AP. Caffeine, practical implications. In: Kanarek R, Lieberman H, eds. Diet, Brain, Behavior: Practical Implications. Boca Raton, FL: CRC Press; 2011:271-292.
40. Davis JK, Green JM. Caffeine and anaerobic performance: An ergogenic value and mechanisms of action. Sports Med. 2009;39:813-832.
41. Ebell MH, Siwek J, Weiss BD, etal. Strength of recommendation taxonomy (sort): A patient-centered approach to grading evidence in the medical literature. Am Fam Physician. 2004;69:548-556.
42. Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992;72:101-163.
43. Zhang M, Izumi I, Kagamimori S, etal. Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino Acids. 2004;26:203-207.
44. Ward RJ, Francaux M, Cuisinier C, etal. Chnages in plasma taurine levels after different endurance events. Amino Acids. 1999;16:71-77.
45. Galloway SDR, Talanian JL, Shoveller AK, etal. Seven days of oral taurine supplementation does not increase muscle taurine content or alter substrate metabolism during prolonged exercise in humans. J Appl Physiol. 2008;105:643-651.
46. Rutherford JA, Spriet LL, Stellingwerff T. The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists. Int J Sport Nutr Exerc Metab. 2010;20:322-329.
47. Idrissi AE. Taurine improves learning and retention in aged mice. Neurosci Lett. 2008;436:19-22.
48. Idrissi AE, Trenkner E. Taurine as a modulator of excitatory and inhibitory neurotransmission. Neurochem Res. 2004;29:189-197.
49. Benrabh H, Bourre J-M, Lefauconnier J-M. Taurine transport at the blood-brain barrier: An in vivo brain perfusion study. Brain Res. 1995;692:57-65.
50. Kang Y-S, Ohtsuki S, Takanaga H, etal. Regulation of taurine at the blood-brain barrier by tumor necrosis factor-α, taurine and hypertonicity. J Neurochem. 2002;83:1188-1195.
51. Ferreira SE, de Mello MT, Rossi MV, etal. Does an energy drink modify the effects of alcohol in a maximal effort test? Alcohol Clin Exp Res. 2004;28:1408-1412.
52. Forbes SC, Candow DG, Little JP, etal. Effect of red bull energy drink on repeated wingate cycle performance and bench-press muscle endurance. Int J Sport Nutr Exerc Metab. 2007;17:433-444.
53. Gendle MH, Smucker DM, Stafstrom JA, etal. Attention and reaction time in university students following the consumptin of Red Bull. Open Nutr J. 2009;3:8-10.
54. Warburton DM, Bersellini E, Sweeney E. An evaluation of a caffeinated taurine drink on mood, memory and information processing in healthy volunteers without caffeine abstinence. Psychopharmacology (Berl). 2001;158:322-328.
55. Ragsdale FR, Gronli TD, Batool N, etal. Effect of Red Bull energy drink on cardiovascular and renal function. Amino Acids. 2010;38:1193-1200.
56. Candow DG, Kleisinger AK, Grenier S, etal. Effect of sugar-free Red Bull energy drink on high-intensity run time-to-exhaustion in young adults. J Strength Cond Res. 2009;23:1271-1275.
57. Alford C, Cox H, Wescott R. The effects of Red Bull energy drink on human performance and mood. Amino Acids. 2001;21:139-150.
58. Rahnama N, Gaeini AA, Kazemi F. The effectiveness of two energy drinks on selected indices of maximal cardiorespiratory fitness and blood lactate levels in male athletes. J Res Med Sci. 2010;15:127-132.
59. Deixelberger-Fritz D, Tischler MA, Kallus KW. Changes in performance, mood state and workload due to energy drinks in pilots. Int J Appl Aviat Stud. 2003;3:195-205.
60. Horne JA, Reyner LA. Beneficial effects of an "energy drink" given to sleepy drivers. Amino Acids. 2001;20:83-89.
61. Reyner LA, Horne JA. Efficacy of a "functional energy drink" in counteracting driver sleepiness. Physiol Behav. 2002;75:331-335.
62. Mets MAJ, Ketzer S, Blom C, etal. Positive effects of Red Bull energy drink on driving performance during prolonged driving. Psychopharmacology (Berl). 2011;214:737-745.
63. Bichler A, Swenson A, Harris MA. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids. 2006;31:471-476.
64. Seidl R, Peyrl A, Nicham R, etal. A taurine and caffeine-containing drink stimulates cognitive performance and well-being. Amino Acids. 2000;19:635-642.
65. Geiß K-R, Jester I, Falke W, etal. The effect of a taurine-containing drink on performance in 10 endurance-athletes. Amino Acids. 1994;7:45-56.
66. Bell DG, McLellan TM. Exercise endurance 1, 3 and 6h after caffeine ingestion in caffeine users and nonusers. J Appl Physiol. 2002;93:1227-1234.
67. Baum M, Weiß M. The influence of a taurine containing drink on cardiac parameters before and after exercise measured by echocardiography. Amino Acids. 2001;20:75-82.
68. Barthel T, Mechau D, Wehr T, etal. Readiness potential in different states of physical activation and after ingestion of taurine and/or caffeine drinks. Amino Acids. 2001;20:63-73.
69. Imagawa TF, Hirano I, Utsuki K, etal. Caffeine and taurine enhance endurance performance. Int J Sports Med. 2009;30:485-488.
70. Kimura M, Ushijima I, Hiraki M, etal. Enhancement of caffeine-induced locomotor hyperactivity produced by combination with l-arginine or taurine in mice: Possible involvement of nitric oxide. Methods Find Exp Clin Pharmacol. 2009;31:585-589.
71. Riesenhuber A, Boehm M, Posch M, etal. Diruetic potential of energy drinks. Amino Acids. 2006;31:81-83.
72. Storey IDE. The synthesis of glucuronides by liver slices. Biochem J. 1950;47:212-222.
73. Dowben RM. The fate of sodium glucuronate glucuronolactone in man. J Clin Invest. 1956;35:277-280.
74. Tamura S, Tsutsumi S, Ito H, etal. Effects of glucuronolactone and the other carbohydrates on the biochemical changes produced in the living body of rats by hard exercise. Jpn J Pharmacol. 1968;18:30-38.
75. Coyle EF, Hagberg JM, Hurley BF, etal. Carbohydrate feeding during prolonged strenuous exercise can delay fatigue. J Appl Physiol. 1983;55:230-235.
76. Coyle EF, Coggan AR, Hemmert MK, etal. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol. 1986;61:165-172.
77. Coyle EF. Fluid and fuel intake during exercise. J Sport Sci. 2004;22:39-55.
78. Hulston CJ, Jeukendrup AE. Substrate metabolism and exercise performance with caffeine and carbohydrate intake. Med Sci Sports Exerc. 2008;40:2096-2104.
79. Ganio MS, Klau JF, Lee EC, etal. Effect of various carbohydrate-electrolyte fluids on cycling performance and maximal voluntary contraction. Int J Sport Nutr Exerc Metab. 2010;20:104-114.
80. Conger SA, Warren GL, Hardy MA, etal. Does caffeine added to carbohydrate provide additional ergogenic benefit for endurance? Int J Sport Nutr Exerc Metab. 2011;21:71-84.
81. Pedersen DJ, Lessard SJ, Coffey VG, etal. High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. J Appl Physiol. 2008;105:7-13.
82. Horne JA, Anderson C. Effects of a high sugar content "energy" drink on driver sleepiness. London: Department for Transport; Behavioural Research in Road Safety 2005. 2005; Fifteenth Seminar: 147-155.
83. Scholey AB, Kennedy DO. Cognitive and physiological effects of an "energy drink": An evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions. Psychopharmacology (Berl). 2004;176:320-330.
84. Adan A, Serra-Grabulosa JM. Effects of caffeine and glucose, alone and combined, on cognitive performance. Hum Psychopharmacol. 2010;25:310-317.
85. Williams MH. Dietary supplements and sports performance: Introduction and vitamins. J Int Soc Sports Nutr. 2004;1:1-6.
86. Rosenbloom C. Can vitamins and mineral supplements improve sports performance? Nutr Today. 2007;42:74-80.
87. Milunsky A, Jick H, Jick SS, etal. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. J Am Med Assoc. 1989;262:2847-2852.
88. Durga J, van Boxtel MPJ, Shouten EG, etal. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: A randomised, double blind, controlled trial. Lancet. 2007;369:208-216.
89. Smith N, Atroch AL. Guarana's journey from regional tonic to aphrodisiac and global energy drink. Evid Based Complement Alternat Med. 2010;7:279-282.
90. Weckerle CS, Stutz MA, Baumann TW. Purine alkaloids in paullinia. Phytochemistry. 2003;64:735-742.
91. Lima WP, Carnevali LC, Eder R, etal. Lipid metabolism in trained rats: Effect of guarana (Paullinia cupana mart.) supplementation. Clin Nutr. 2005;24:1019-1028.
92. Espinola EB, Dias RF, Mattei R, etal. Pharmacological activity of guarana (Paullinia cupana mart.) in laboratory animals. J Ethnopharmacol. 1997;55:223-229.
93. Mattei R, Dias RF, Espinola EB, etal. Guarana (Paullinia cupana): Toxic behavioral effects in laboratory animals and antioxidant activity in vitro. J Ethnopharmacol. 1998;60:111-116.
94. Subbiah MTR, Yunker R. Studies on the nature of anti-platelet aggregatory factors in the seeds of the Amazonian herb guarana (Paullinia cupana). Int J Vitam Nutr Res. 2008;78:96-101.
95. Campos AR, Barros AIS, Albuquerque FAA, etal. Acute effects of guarana (Paullinia cupana mart.) on mouse behaviour in forced swimming and open field tests. Phytother Res. 2005;19:441-443.
96. Otobone FJ, Sanches ACC, Nagae R, etal. Effect of lyophilized extracts from guaraná seeds [paullinia cupana var. Sorbilis (mart.) ducke] on behavioral profiles in rats. Phytother Res. 2007;21:531-535.
97. Galduroz JCF, Carlini EA. Acute effects of the Paullinia cupana, "guarana" on the cognition of normal volunteers. Sao Paulo Med J. 1994;112:607-611.
98. Galduroz JCF, Carlini EA. The effects of long-term administration of guarana on the cognition of normal, elderly volunteers. Sao Paulo Med J. 1996;114:1073-1078.
99. Lieberman HR, Wurtman RJ, Emde GG, etal. The effects of low doses of caffeine on human performance and mood. Psychopharmacology (Berl). 1987;92:308-312.
100. Bérubé S, Pelletier C, Doré J, etal. Effects of encapsulated green tea and guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24h energy expenditure and fat oxidation in men. Br J Nutr. 2005;94:432-436.
101. Kennedy DO, Haskell CF, Robertson B, etal. Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guaraná (Paullinia cupana). Appetite. 2008;50:506-513.
102. Meyer K, Ball P. Psychological and cardiovascular effects of guaraná and yerba maté: A comparison with coffee. Interam J Psychol. 2004;38:87-94.
103. Kennedy DO, Haskell CF, Wesnes KA, etal. Improved cognition performance in human volunteers following administration of guarana (Paullinia cupana) extract: Comparison and interaction with Panax ginseng. Pharmacol Biochem Behav. 2004;79:401-411.
104. Haskell CF, Kennedy DO, Wesnes KA, etal. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. J Psychopharmacol. 2007;21:65-70.
105. McLellan TM, Bell DG. The impact of prior coffee consumption on the subsequent ergogenic effect of anyhydrous caffeine. Int J Sport Nutr Exerc Metab. 2004;14:698-708.
106. Heck CI, Meji EG. Yerba mate tea (Ilex paraguariensis): A comprehensive review on chemistry, health implications, and technological considerations. J Food Sci. 2007;72:138-151.
107. Meinhart AD, Bizzotto CS, Ballus CA, etal. Methylxanthines and phenolics content extracted during the consumption of mate (Ilex paraguariensis st. Hil) beverages. J Agric Food Chem. 2010;58:2188-2193.
108. Milioli EM, Cologni P, Santos CC, etal. Effect of acute administration of hydroalcohol extract of Ilex paraguariensis St. Hilaire (aquifoliaceae) in animal models of Parkinson's disease. Phytother Res. 2007;21:771-776.
109. Vieira MA, Maraschin M, Pagliosa CM, etal. Phenolic acids and methylxanthines composition and antioxidant properties of mate (Ilex paraguariensis) residue. J Food Sci. 2010;75:280-285.
110. Puangpraphant S, de Mejia EG. Saponins in yerba mate tea (Ilex paraguariensis a. St.-hil) and quercetin synergistically inhibit inos and cox-2 in lipopolysaccharide-induced macrophages through NFK{green}β pathways. J Agric Food Chem. 2009;57:8873-8883.
111. Prediger RDS, Fernandes MS, Rial D, etal. Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory. J Ethnopharmacol. 2008;120:465-473.
112. Murosaki S, Lee TR, Muroyama K, etal. A combination of caffeine, arginine, soy isoflavones, and l-carnitine enhances both lipolysis and fatty acid oxidation in 3T3-L1 and HepG2 cells in vitro and in KK mice in vivo. J Nutr. 2007;137:2252-2257.
113. Cha Y-S, Choi S-K, Suh H, Lee S-N, Cho D, Lim K. Effects of carnitine coingested caffeine on carnitine metabolism and endurance capacity in athletes. J Nutr Sci Vitaminol (Tokyo). 2001;47:378-384.
114. Brouns F, van der Vusse GJ. Utilization of lipids during exercise in human subjects: Metabolic and dietary constraints. Br J Nutr. 1998;79:117-128.
115. Graham TE, Battram DS, Dela F, etal. Does caffeine alter muscle carbohydrate and fat metabolism during exercise? Appl Physiol Nutr Metab. 2008;33:1311-1318.
116. Hadjicharalambous MP, Kilduff LP, Pitsiladis YP. Brain serotonergic and dopaminergic modulators, perceptual responses and endurance exercise performance following caffeine co-ingested with a high fat meal in trained humans. J Int Soc Sports Nutr. 2010;7:22-31.
117. Linde K, Berner MM, Kriston L. St. John's wort for major depression. Cochrane Database Syst Rev. 2008;(4):CD000448.
118. Shelton RC, Keller MB, Gelenberg A, etal. Effectiveness of St. John's wort in major depression. J Am Med Assoc. 2001;285:1978-1986.
119. Uzbay IT, Coskun I, Kayir H, etal. Extract of Hypericum perforatum blocks caffeine-induced locomotor activity in mice: A possible role of nitric oxide. Phytother Res. 2007;21:415-419.
120. Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr. 2000;72(Suppl):S624-S636.
121. Lieberman HR. The effects of ginseng, ephedrine, and caffeine on cognitive performance, mood and energy. Int J Sport Nutr Exerc Metab. 2001;15:75-83.
122. Geng J, Dong J, Ni H, etal. Ginseng for cognition. Cochrane Database Syst Rev. 2010;(8):CD007769.
123. Goulet ED. Assessment of the effects of Eleutherococcus senticosus on endurance performance. Int J Sport Nutr Exerc Metab. 2005;15:75-83.
124. Bahrke MS, Morgan WP, Stegner A. Is ginseng an ergogenic aid? Int J Sport Nutr Exerc Metab. 2009;19:298-322.
125. Armstrong LE, Casa DJ, Maresh etal. Caffeine, fluid-electrolyte balance, temperature regulation, and exercise-heat tolerance. Exerc Sport Sci Rev. 2007;35:135-140.
126. Fredholm BB, Bättig K, Holmén J, etal. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51:83-133.
127. Smith AP, Sturgess W, Gallagher J. Effects of a low dose of caffeine given in different drinks on mood and performance. Hum Psychopharmacol. 1999;14:473-482.
128. Durlach PJ. The effects of a low dose of caffeine on cognitive performance. Psychopharmacology (Berl). 1999;140:116-119.
129. Graham TE, Spriet LL. Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. J Appl Physiol. 1995;78:867-874.
130. Cox GR, Desbrow B, Montgomery PG, etal. Effect of different protocols of caffeine intake on metabolism and endurance performance. J Appl Physiol. 2002;93:990-999.
131. Bell DG, McLellan TM. Effect of repeated caffeine ingestion on repeated exhaustive exercise endurance. Med Sci Sports Exerc. 2003;35:1348-1354.
132. Andrews KW, Schweitzer A, Zhao C, etal. The caffeine contents of dietary supplements commonly purchased in the US: Analysis of 53 products with caffeine-containing ingredients. Anal Bioanal Chem. 2007;389:231-239.