Studies on the nature of anti-platelet aggregatory factors in the seeds of the Amazonian herb guarana (Paullinia cupana)

International Journal for Vitamin and Nutrition Research

Volumn 78, Issue 2, 2008, Pages 96-101

  Ravi Subbiah, M T ^a   Yunker, Remy ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Caffeine; Catechins; Condensed tannins; Guarana extract; High performance liquid chromatography; Platelet aggregation

Indexed keywords

CAFFEINE; CATECHIN; DIMER; EPICATECHIN;

ARTICLE; BINDING AFFINITY; CARDIOVASCULAR DISEASE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; PAULLINIA; PAULLINIA CUPANA; PLANT SEED; RISK REDUCTION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; PAULLINIA; PLANT EXTRACTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET-RICH PLASMA; SEEDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THROMBOXANES;

PAULLINIA CUPANA;

EID: 54249159547     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.78.2.96     Document Type: Article

References (15)

1. Henman, A. R. (1982) Guarana (Paullinia cupana var sorbilis): Ecological and social perspectives on an economic plant of the Central Amazon Basin. J. Ethnopharmacol. 6, 311.
2. Houghton, P. (1995) Guarana. Pharmaceutical. J. 254, 435.
3. Subbiah, M. T. R. (2005) Guarana consumption. A review of health benefits and risks. Altern. Complement. Ther. 4, 212.
4. Bydlowski, S. P., Yunker, R. L. and Subbiah, M. T. R. (1988) A novel property of aqueous guarana extract (Paullinia cupana): inhibition of platelet aggregation. Braz. J. Med. Biol. Res. 21, 535.
5. Bydlowski, S. P., D'Amico, E. A. and Chamone, D. A. (1991) An aqueous extract of guarana (Paullinia cupana) decreases platelet thromboxane synthesis. Braz. J. Med. Biol. Res. 24, 421.
6. Hirsh, J. (1989) Hyperactive platelets and complications of coronary artery disease. New Engl. J. Med. 316, 1543.
7. Subbiah, M. T. R. (2002) Cardiovascular risk associated with estrogen replacement therapy: some critical questions about the type of estrogen used in most clinical trials. Atherosclerosis 173, 373.
8. Avato, P., Pesante, M. A., Fanizzi, F. P. and Santos, C. A. (2003) Seed oil composition of Paullinia cupana var. sorbilis (Mart) Ducke. Lipids 38, 773.
9. Belliardo, F., Martelli, A. and Valle, M. G. (1985) HPLC determination of caffeine and theophylline in Paullinia cupana Kunth (guarana) and cola spp. Samples. Z. Lebensm. Unters. Forrsch. 180, 398.
10. Benoni, H., Dallakian, P. and Taraz, K. (1996) Studies on the essential oil from guarana. Z. Lebensm. Unters. Forsch. 203, 95.
11. Bempong, D., Houghton, P. J. and Steadman, K. (1991) The caffeine content of guarana. J. Pharm. Pharmacol. 43 (suppl), 125.
12. Marx, F. (1990) Analysis of guarana seeds. II. Studies on the composition of tannin fraction. J. Lebensm. Unters. Forsch. 190, 429.
13. Skjaerland, J. M., Gallon, L. and Subbiah, M. T. R. (1983) Effect of ethynyl estradiol on arachidonic acid incorporation, release and conversion to prostaglandins in rabbit platelets. Biochem. Med. 30, 357.
14. Wey, H., Gallon, L. and Subbiah, M. T. R. (1982) Prostaglandin synthesis in platelets and aorta of Fawn-hooded rats with platelet storage pool disease and its response to cholesterol feeding. Thromb. Haemost. 48, 94.
15. Reuning, R. H. and Levy, G. (1988) Effect of complex formation on drug absorption. J. Pharm. Sci. 57, 1335.