Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-α, taurine and hypertonicity

Journal of Neurochemistry

Volumn 83, Issue 5, 2002, Pages 1188-1195

  Kang, Young Sook ^a,b   Ohtsuki, Sumio ^b   Takanaga, Hitomi ^b   Tomi, Masatoshi ^c   Hosoya, Ken ichi ^c   Terasaki, Tetsuya ^b  

^a Sookmyung Women's University   (South Korea)

^b TOHOKU UNIVERSITY   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Blood brain barrier; Immortalized brain capillary endothelial cell line; MRNA expression; Osmoregulation; Taurine transport; Tumor necrosis factor

Indexed keywords

AMINO ACID TRANSPORTER; BETA ALANINE; CHLORIDE; HYPERTONIC SOLUTION; LIPOPOLYSACCHARIDE; MALEIC ACID DIETHYL ESTER; MESSENGER RNA; SODIUM; TAURINE; TRITIUM; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID BRAIN LEVEL; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CELL DAMAGE; CELL LINE; CONTROLLED STUDY; IN VITRO STUDY; MALE; NEUROPROTECTION; NONHUMAN; OSMOLALITY; OSMOREGULATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; RNA TRANSCRIPTION;

ANIMALS; BETA-ALANINE; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARIES; CARRIER PROTEINS; CELL LINE; CHLORIDES; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HYPERTONIC SOLUTIONS; LIPOPOLYSACCHARIDES; MALE; MALEATES; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; RNA, MESSENGER; SODIUM; TAURINE; TUMOR NECROSIS FACTOR-ALPHA; WATER-ELECTROLYTE BALANCE;

ANIMALIA; TRITIUM;

EID: 0036892753     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01223.x     Document Type: Article

References (40)

1. Benrabh H., Bourre J. M. and Lefauconnier J. M. (1995) Taurine transport at the blood-brain barrier: An in vivo brain perfusion study. Brain Res. 692, 57-65.
2. Bitoun M. and Tappaz M. (2000) Gene expression of the transporters and biosynthetic enzymes of the osmolytes in astrocyte primary cultures exposed to hyperosmotic conditions. Glia 32, 165-176.
3. Boldyrev A. A., Johnson P., Wei Y., Tan Y. and Carpenter D. O. (1999) Camosine and taurine protect rat cerebellar granular cells from free radical damage. Neurosci. Lett. 263, 169-172.
4. Chen W. Q., Jin H., Nguyen M., Carr J., Lee Y. J., Hsu C. C., Faiman M. D., Schloss J. V. and Wu J. Y. (2001) Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons. J. Neurosci. Res. 66, 612-619.
5. De Petris L., Luchetti A. and Emma F. (2001) Cell volume regulation and transport mechanisms across the blood-brain barrier: Implications for the management of hypematraemic states. Eur. J. Pediatr. 160, 71-77.
6. French E. D., Vezzani A., Whetsell W. O. Jr and Schwarcz R. (1986) Anti-excitotoxic actions of taurine in the rat hippocampus studied in vivo and in vitro. Adv. Exp. Med. Biol. 203, 349-362.
7. Han X., Chesney R. W., Budreau A. M. and Jones D. P. (1996) Regulation of expression of taurine transport in two continuous renal epithelial cell lines and inhibition of taurine transporter by a site-directed antibody. Adv. Exp. Med. Biol. 403, 173-191.
8. Han X., Budreau A. M. and Chesney R. W. (1997) Functional expression of rat renal cortex taurine transporter in Xenopus laevis oocytes: Adaptive regulation by dietary manipulation. Pediatr Res. 41, 624-631.
9. Han X., Budreau A. M. and Chesney R. W. (1999) Ser-322 is a critical site for PKC regulation of the MDCK cell taurine transporter (pNCT). J. Am. Soc. Nephrol. 10, 1874-1879.
10. Han X., Budreau A. M. and Chesney R. W. (2000) Cloning and characterization of the promoter region of the rat taurine transporter (TauT) gene. Adv. Exp. Med. Biol. 483, 97-108.
11. Heller-Stilb B., van Roeyen C., Rascher K., Hartwig H. G., Huth A., Seeliger M. W., Warskulat U. and Haussinger D. (2002) Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J. 16, 231-233.
12. Hosoya K., Takashima T., Tetsuka K., Nagura T., Ohtsuki S., Takanaga H., Ueda M., Yanai N., Obinata M. and Terasaki T. (2000) mRNA expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting. J. Drug Target. 8, 357-370.
13. Huxtable R. J. (1992) Physiological actions of taurine. Physiol. Rev. 72, 101-163.
14. Huxtable R. J. and Lippincott S. E. (1982) Relative contribution of diet and biosynthesis to the taurine content of the adult rat. Drug Nutr. Interact. 1, 153-168.
15. Kang Y. S. (2000) Taurine transport mechanism through the blood-brain barrier in spontaneously hypertensive rats. Adv. Exp. Med. Biol. 483, 321-324.
16. Loo D. D., Hirsch J. R., Sarkar H. K. and Wright E. M. (1996) Regulation of the mouse retinal taurine transporter (TAUT) by protein kinases in Xenopus oocytes. FEBS Lett. 392, 250-254.
17. Matsumoto K., Lo E. H., Pierce A. R., Halpern E. F. and Newcomb R. (1996) Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16, 114-124.
18. Meistrell M. E., 3rd Botchkina G. I., Wang H., Di Santo E., Cockroft K. M., Bloom O., Vishnubhakat J. M., Ghezzi P. and Tracey K. J. (1997) Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia. Shock 8, 341-348.
19. Miyakawa H., Woo S. K., Dahl S. C., Handler J. S. and Kwon H. M. (1999) Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc. Natl. Acad. Sci. USA 96, 2538-2542.
20. Miyamoto Y., Liou G. I. and Sprinkle T. J. (1996) Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium. Curr. Eye Res. 15, 345-349.
21. Miyasaka T., Kaminogawa S., Shimizu M., Hisatsune T., Reinach P. S. and Miyamoto Y. (2001) Characterization of human taurine transporter expressed in insect cells using a recombinant baculovirus. Protein Expr. Purif. 23, 389-397.
22. Mochizuki T., Satsu H. and Shimizu M. (2002) Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells. FEBS Lett. 517, 92-96.
23. Nakane H., Yao H., Ibayashi S., Kitazono T., Ooboshi H., Uchimura H. and Fujishima M. (1998) Protein kinase C modulates ischemia-induced amino acids release in the striatum of hypertensive rats. Brain Res. 782, 290-296.
24. Oja S. S. and Saransaari P. (1996) Taurine as osmoregulator and neuromodulator in the brain. Metab. Brain Dis. 11, 153-164.
25. Rim J. S., Atta M. G., Dahl S. C., Berry G. T., Handler J. S. and Kwon H. M. (1998) Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5′-flanking region. J. Biol. Chem. 273, 20615-20621.
26. Saransaari P. and Oja S. S. (1997) Enhanced taurine release in cell-damaging conditions in the developing and ageing mouse hippocampus. Neuroscience 79, 847-854.
27. Saransaari P. and Oja S. S. (2000) Taurine and neural cell damage. Amino Acids 19, 509-526.
28. Satsu H., Miyamoto Y. and Shimizu M. (1999) Hypertonicity stimulates taurine uptake and transporter gene expression in Caco-2 cells. Biochim. Biophys. Acta 1419, 89-96.
29. Shohami E., Novikov M., Bass R., Yamin A. and Gallily R. (1994) Closed head injury triggers early production of TNF-α and IL-6 by brain tissue. J. Cereb. Blood Flow Metab. 14, 615-619.
30. Shohami E., Ginis I. and Hallenbeck J. M. (1999) Dual role of tumor necrosis factor alpha in brain injury. Cytokine Growth Factor Rev. 10, 119-130.
31. Smith K. E., Borden L. A., Wang C. H., Hartig P. R., Branchek T. A. and Weinshank R. L. (1992) Cloning and expression of a high affinity taurine transporter from rat brain. Mol. Pharmacol. 42, 563-569.
32. Takanaga H., Ohtsuki S., Hosoya K. and Terasaki T. (2001) GAT2/BGT-1 as a system responsible for the transport of γ-aminobutyric acid at the mouse blood-brain barrier. J. Cereb. Blood Flow Metab. 21, 1232-1239.
33. Takanaga H., Tokuda N., Ohtsuki S., Hosoya K. and Terasaki T. (2002) ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline. Mol. Pharmacol. 61, 1289-1296.
34. +- and Cl-dependent transport of taurine at the blood-brain barrier. Biochem. Pharmacol. 50, 1783-1793.
35. Terasaki T. and Hosoya K. (2001) Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions. Biol. Pharm. Bull. 24, 111-118.
36. Tsuji A. and Tamai I. (1996) Sodium- and chloride-dependent transport of taurine at the blood-brain barrier. Adv. Exp. Med. Biol. 403, 385-391.
37. Tuz K., Ordaz B., Vaca L., Quesada O. and Pasantes-Morales H. (2001) Isovolumetric regulation mechanisms in cultured cerebellar granule neurons. J. Neurochem. 79, 143-151.
38. --dependent taurine transporter that is regulated by hypertonicity. Proc. Natl. Acad. Sci. USA 89, 8230-8234.
39. Uchiyama-Tsuyuki Y., Araki H., Yae T. and Otomo S. (1994) Changes in the extracellular concentrations of amino acids in the rat striatum during transient focal cerebral ischemia. J. Neurochem. 62, 1074-1078.
40. Vinnakota S., Qian X., Egal H., Sarthy V. and Sarkar H. K. (1997) Molecular characterization and in situ localization of a mouse retinal taurine transporter. J. Neurochem. 69, 2238-2250.