Saponins in yerba mate tea (Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFκB pathways

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 19, 2009, Pages 8873-8883

  Puangpraphant, Sirima ^a   De Mejia, Elvira Gonzalez ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cyclooxygenase 2 (COX 2); NF B; Prostaglandin E2 (PGE2); Quercetin; RAW264.7 macrophages; Saponins; Yerba mate tea phytochemicals

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; QUERCETIN; SAPONIN;

ANIMAL; ARTICLE; BEVERAGE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; ILEX PARAGUARIENSIS; MACROPHAGE; METABOLISM; MOUSE;

ANIMALS; BEVERAGES; CELL LINE; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DRUG SYNERGISM; ENZYME INHIBITORS; ILEX PARAGUARIENSIS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; QUERCETIN; SAPONINS;

CROTON OVALIFOLIUS; ILEX PARAGUARIENSIS;

EID: 70349912042     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf902255h     Document Type: Article

References (37)

1. Heck, C. I.; Gonzalez de Mejia, E. Yerba mate tea (Ilex paraguartensis): a comprehensive review on chemistry, health implications, and technological considerations. J. Food Sci. 2007, 72, 138-151.
2. Lafuente, A. G.; Guillamon, E.; Villares, A.; Rostagno, A.; Martinez, J. A. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflammation Res. 2009, 58, 537-552.
3. Agarwal, S.; Reddy, G. V.; Reddanna, P. Eicosanoids in inflammation and cancer: the role of COX-2. Expert review. Clin. Immunol. 2009, 5, 145-165.
4. Kundu, J. K.; Surh, Y. Inflammation: gearing the journey to cancer. Mutat. Res. Rev. Mutat. Res. 2008, 659, 15-30.
5. Granic, I.; Dolga, A. M.; Nijholt, I. M.; van Dijk, G.; Eisel, U. L. M. Inflammation and NF-κB in Alzheimer's disease and diabetes. J. Alzheimer's Dis. 2009, 16, 809-821.
6. Ramirez-Mares, M. V.; Chandra, S.; de Mejia, E. G. In vitro chetnopreventive activity of Camellia sinesis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols. Mutat. Res. 2004, 554, 53-65.
7. de Mejia, E. G.; Song, Y.; Ramirez-Mares, M. V.; Kobayashi, H. Effect of yerba mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral carcinoma cell proliferation. J. Agric. Food Chem. 2005, 53, 1966-1973. (Pubitemid 40403053)
8. Gnoatto, S. C. B.; Dassonville-Klimpt, A.; Da Nascimento, S.; Galera, P.; et al. Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. Eur. J. Med. Chem. 2008, 43, 1865-1877.
9. Itzkowitz, S. H.; Yio, X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 287, G7-17.
10. Mu, M. M.; Chakravortty, D.; Sugiyama, T.; Koide, N.; et al. The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. J. Endotoxin Res. 2001, 7, 431-438. (Pubitemid 34048526)
11. Liang, Y. C.; Huang, Y. T.; Tsai, S. H.; Lin-Shiau, S. Y.; et al. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 1999, 20, 1945-1952. (Pubitemid 29476121)
12. Raso, G. M.; Meli, R.; Di Carlo, G.; Pacilio, M.; Di Carlo, R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 2001, 68, 921-931. (Pubitemid 32168067)
13. Warren, C. A.; Paulhill, K. J.; Davidson, L. A.; Lupton, J. R.; et al. Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. J. Nutr. 2009, 139, 101-105.
14. Sur, P.; Chaudhuri, T.; Vedasiromoni, J. R.; Gomes, A.; Ganguly, D. K. Antiinflammatory and antioxidant property of saponins of tea Camellia sinensis root extract. Phytother. Res. 2001, 15, 174-176.
15. Aggarwal, B. B.; Shishodia, S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71, 1397-1421.
16. Dixit, V.; Mak, T. W. NF-κB Signaling: many roads lead to Madrid. Cell 2002, 111, 615-619.
17. Shishodia, S.; Majumdar, S.; Banerjee, S.; Aggarwal, B. B. Ursolic acid inhibits nuclear factor-κB activation induced by carcinogenic agents through suppression of IκBα kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res. 2003, 63, 4375-4383.
18. Assis Jacques, R.; dos Santos Freitas, L.; Flores Peres, V.; Dariva, C.; et al. Chemical composition of mate tea leaves (Ilex paraguariensis): a study of extraction methods. J. Sep. Sci. 2006, 18, 2780-2784.
19. Gnoatto, S.; Schenkel, E. P.; Bassani, V. L. HPLC method to assay total saponins in Ilex paraguariensis aqueous extract. J. Braz. Chem. Soc. 2005, 4, 723-726.
20. Gessner, P. K. Isobolographic analysis of interactions: an update on applications and utility. Toxicology 1995, 105, 161-179.
21. Bracesco, N.; Dell, M.; Rocha, A.; Behtas, S.; et al. Antioxidant activity of a botanical extract preparation of Ilex paraguariensis: prevention of DNA double-strand breaks in Saccharomyces cerevisiae and human low-density lipoprotein oxidation. J. Altern. Complement. Med. 2003, 9, 379-387.
22. Lunceford, N.; Gugliucci, A. Ilex paraguariensis inhibit AGE formation more efficiently than green tea. Fitoterapia 2005, 76, 419-427. (Pubitemid 40922601)
23. Chandra, S.; de Mejia, E. G. Polyphenols compounds, antioxidant capacity, and reductase activity of an aqueous extract of Ardisia compressa in comparison to mate (Ilex paraguariensis) and green (Camellia sinensis) teas. J. Agric. Food Chem. 2004, 52, 3583-3589.
24. Bastos, D. H. M.; Ishimoto, E. Y.; Marques, M. O. M.; Ferri, A. F.; Torres, E. A. F. S. Essential oil and antioxidant activity of green mate and mate tea (Ilex paraguariensis) infusions. J. Food Compos. Anal. 2006, 19, 538-543.
25. Menini, T.; Heck, C.; Shulze, J.; de Mejia, E.; Gugliucci, A. Protective action of Ilex paraguariensis extract against free radical inactivation of paraoxonase-1 in high density lipoprotein. Planta Med. 2007, 73, 1141-1147. (Pubitemid 47572347)
26. 2-induced DNA damage and DNA repair in mice. Mutagenesis 2008, 23, 261-265.
27. Oliveira, D. M.; Freitas, H. S.; Souza, M. F.; Arçari, D. P.; et al. Yerba maté (Ilex paraguariensis) aqueous extract decreases intestinal SGLT1 gene expression but does not affect other biochemical parameters in alloxan-diabetic Wistar rats. J. Agric, Food Chem. 2008, 56, 10527-10532.
28. Pang, J.; Choi, Y.; Park, T. Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissue. Arch. Biochem. Biophys. 2008, 476, 178-185.
29. Lanzetti, M.; Bezerra, F. S.; Romana-Souza, B.; Brando-Lima, A. C.; et al. Mate tea reduced acute lung inflammation in mice exposed to cigarette smoke. Nutrition 2008, 24 (4), 375-381.
30. Fernández-Dueñas, V.; Sánchez, S.; Planas, E.; Poveda, R. Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. Eur. J. Pain 2008, 12, 157-163. (Pubitemid 350186120)
31. Gepdiremen, A.; Mshvildadze, V.; Suleyman, H.; Elias, R. Acute and chronic anti-inflammatory effects of Hedera colchica in rats. J. Ethnopharmacol. 2004, 94, 191-195. (Pubitemid 38942852)
32. Suh, N.; Honda, T.; Finlay, H. J.; Barchowsky, A.; et al. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res. 1998, 58, 717-723.
33. Wang, J.; Mazza, G. Effects of anthocyanins and other phenolic compounds on the production of tumor necrosis factor in LPS/IFN-γ-activated RAW 264.7 macrophages. J. Agric. Food Chem. 2002, 50, 4183-4189. (Pubitemid 34756012)
34. Shan, J.; Fu, J.; Zhao, Z.; Kong, X.; Huang, H.; Luo, L.; Yin, Z. Chlorogenic acid inhibits lipopolysaccharide-induced cycloxygenase-2 expression in RAW 264.7 cells through suppressing NF-κB and JNK/AP-1 activation. Int. Immunopharmacol. 2009, 9, 1042-1048.
35. Heck, C. I.; Schmalko, M.; de Mejia, E. G. Effect of growing and drying conditions on the phenolic composition of mate teas (Ilex paraguariensis). J. Agric. Food Chem. 2008, 56, 8394-8403.
36. Peyrat-Maillard, M.; Cuvelier, M.; Berset, C. Antioxidant activity of phenolic compounds in 2,2′-azobis(2-amidinopropane) diliydrochloride (AAPH)-induced oxidation: synergistic and antagonistic effects. J. Am. Oil Chem. Soc 2003, 80, 1007-1012.
37. Lambert, J. D.; Sang, S.; Yang, C. S. Possible controversy over dietary polyphenols: benefits vs risks. Chem. Res. Toxicol. 2007, 20, 583-585.