-
1
-
-
59649117667
-
Molecular biology of inflammation and sepsis: A primer
-
Cinel I, Opal SM. Molecular biology of inflammation and sepsis: a Primer. Crit Care Med. 2009;37(1):291-304.
-
(2009)
Crit Care Med
, vol.37
, Issue.1
, pp. 291-304
-
-
Cinel, I.1
Opal, S.M.2
-
2
-
-
84862908403
-
A genomic storm in critically injured humans
-
doi:10.1084/jem.20111354. This large study clearly demonstrates that the genes altered in acute systemic inflammation following severe injury follow similar patterns of upregulation and down regulation in patients that survive and those that do not survive. The differences in gene expression between survivors and non-survivors are primarily quantitative and not qualitative differences
-
Xiao W, Mindrinos MN, Seok J, et al. A genomic storm in critically injured humans. J Exp Med. 2011. doi:10.1084/jem.20111354. This large study clearly demonstrates that the genes altered in acute systemic inflammation following severe injury follow similar patterns of upregulation and down regulation in patients that survive and those that do not survive. The differences in gene expression between survivors and non-survivors are primarily quantitative and not qualitative differences.
-
J Exp Med
, vol.2011
-
-
Xiao, W.1
Mindrinos, M.N.2
Seok, J.3
-
3
-
-
78650915637
-
Immunodeficiency and genetic defects of pattern recognition receptors
-
This is an excellent review of the current state of knowledge about pattern recognition receptors, their microbial ligands, and the innate immune response to invasive pathogens
-
Netea MG, van der Meer JWM. Immunodeficiency and genetic defects of pattern recognition receptors. N Engl J Med. 2011;464 (1):60-70. This is an excellent review of the current state of knowledge about pattern recognition receptors, their microbial ligands, and the innate immune response to invasive pathogens.
-
(2011)
N Engl J Med
, vol.464
, Issue.1
, pp. 60-70
-
-
Netea, M.G.1
Van Der Meer, J.W.M.2
-
4
-
-
77951269392
-
The aim2 inflammasome is essential for host defense against cytosolic bacteria and dna viruses
-
Rathinam VAK, Jiang Z, Waggoner SN, et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol. 2010;11(5):395-403.
-
(2010)
Nat Immunol
, vol.11
, Issue.5
, pp. 395-403
-
-
Rathinam, V.A.K.1
Jiang, Z.2
Waggoner, S.N.3
-
5
-
-
77950349016
-
Th17 and regulatory t cells in mediating and restraining inflammation
-
Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010;140:845-58.
-
(2010)
Cell
, vol.140
, pp. 845-58
-
-
Littman, D.R.1
Rudensky, A.Y.2
-
6
-
-
3142724031
-
Toll-like receptor signaling
-
Akira S, Takeda K. Toll-like receptor signaling. Nat Rev Immunol. 2004;4:499-511.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
7
-
-
3142654210
-
Inferences, questions and possibilities in toll-like receptor signaling
-
Beutler B. Inferences, questions and possibilities in toll-like receptor signaling. Nature. 2004;430:257-63.
-
(2004)
Nature
, vol.430
, pp. 257-63
-
-
Beutler, B.1
-
8
-
-
0035142620
-
Inhibition of bacterial superantigens by peptides and antibodies
-
Visvanathan K, Charles A, Bannan J, Pugach P, Kashfi K, Zabriskie J. Inhibition of bacterial superantigens by peptides and antibodies. Infect Immun. 2001;69:875-84.
-
(2001)
Infect Immun
, vol.69
, pp. 875-84
-
-
Visvanathan, K.1
Charles, A.2
Bannan, J.3
Pugach, P.4
Kashfi, K.5
Zabriskie, J.6
-
9
-
-
80053319600
-
Binding of superantigen toxins into the cd28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock
-
This study elucidates the mechanism by which superantigens trigger the release of inflammatory cytokines resulting in septic shock
-
Arad G, Levy R, Nasie I, et al. Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock. PLoS Biology. 2011;9:e1001149. This study elucidates the mechanism by which superantigens trigger the release of inflammatory cytokines resulting in septic shock.
-
(2011)
PLoS Biology
, vol.9
-
-
Arad, G.1
Levy, R.2
Nasie, I.3
-
10
-
-
33748057490
-
Human intravenous immunoglobulin for experimental streptococcal toxic shock: Bacterial clearance and modulation of inflammation
-
Sriskandan S, Ferguson M, Elliot V, Faulkner L, Cohen J. Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation. J Antimicrob Chemother. 2006;58(1):117-24.
-
(2006)
J Antimicrob Chemother
, vol.58
, Issue.1
, pp. 117-24
-
-
Sriskandan, S.1
Ferguson, M.2
Elliot, V.3
Faulkner, L.4
Cohen, J.5
-
11
-
-
34247623265
-
Coagulation abnormalities in critically ill patients
-
Levi M, Opal SM. Coagulation abnormalities in critically ill patients. Crit Care. 2006;10:222-8.
-
(2006)
Crit Care
, vol.10
, pp. 222-8
-
-
Levi, M.1
Opal, S.M.2
-
12
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein c pathway
-
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002;296(5574):1880-2.
-
(2002)
Science
, vol.296
, Issue.5574
, pp. 1880-2
-
-
Riewald, M.1
Petrovan, R.J.2
Donner, A.3
Mueller, B.M.4
Ruf, W.5
-
13
-
-
0034648757
-
Thrombin signaling and protease-Activated receptors
-
Coughlin SR. Thrombin signaling and protease-Activated receptors. Nature. 2000;407(6801):258-64.
-
(2000)
Nature
, vol.407
, Issue.6801
, pp. 258-64
-
-
Coughlin, S.R.1
-
14
-
-
79960076322
-
A matrix metalloprotease-par1 system regulates vascular integrity, systemic inflammation and death in sepsis
-
Tressel SL, Kaneider NC, Foley C, et al. A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis. EMBO Mol Med. 2011;3:1-15.
-
(2011)
EMBO Mol Med
, vol.3
, pp. 1-15
-
-
Tressel, S.L.1
Kaneider, N.C.2
Foley, C.3
-
15
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348:138-50.
-
(2003)
N Engl J Med
, vol.348
, pp. 138-50
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
16
-
-
66749164669
-
Tilting toward immunosuppression
-
This is a superb review of the problem of sepsis-induced immune suppression and the potential therapeutic options to restore immune function in these vulnerable patients
-
Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA. Tilting toward immunosuppression. Nat Med. 2009;15(5):496-7. This is a superb review of the problem of sepsis-induced immune suppression and the potential therapeutic options to restore immune function in these vulnerable patients.
-
(2009)
Nat Med
, vol.15
, Issue.5
, pp. 496-7
-
-
Hotchkiss, R.S.1
Coopersmith, C.M.2
McDunn, J.E.3
Ferguson, T.A.4
-
17
-
-
33750288937
-
Apoptosis and caspases regulate death and inflammation in sepsis
-
Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol. 2006;6:813-22.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 813-822
-
-
Hotchkiss, R.S.1
Nicholson, D.W.2
-
18
-
-
77954183132
-
Immunotherapy for sepsis-A new approach against an ancient foe
-
Hotchkiss RS, Opal SM. Immunotherapy for sepsis-A new approach against an ancient foe. N Engl J Med. 2010;361(1):87-9.
-
(2010)
N Engl J Med
, vol.361
, Issue.1
, pp. 87-9
-
-
Hotchkiss, R.S.1
Opal, S.M.2
-
19
-
-
84255194001
-
Immunosuppression in patients who die of sepsis and multiple organ failure
-
This study provides compelling pathologic and immunologic evidence that sepsis-induced immune suppression is commonplace in septic patients and the dominant finding in human lethal septic shock
-
Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. 2011;306(23):2594-605. This study provides compelling pathologic and immunologic evidence that sepsis-induced immune suppression is commonplace in septic patients and the dominant finding in human lethal septic shock.
-
(2011)
JAMA
, vol.306
, Issue.23
, pp. 2594-605
-
-
Boomer, J.S.1
To, K.2
Chang, K.C.3
-
20
-
-
84856655455
-
Innate response activator b cells protect against microbial sepsis
-
doi:10.1126/science.1215173
-
Rauch PJ, Chudnovskiy A, Robbins CS, et al. Innate response activator B cells protect against microbial sepsis. Science. 2012. doi:10.1126/science. 1215173.
-
(2012)
Science
-
-
Rauch, P.J.1
Chudnovskiy, A.2
Robbins, C.S.3
-
21
-
-
77957863618
-
Tlr-mediated b cell activation results in ectopic clip expression that promotes b celldependent inflammation
-
Newell MK, Tobin RP, Cabrera JH, et al. TLR-mediated B cell activation results in ectopic CLIP expression that promotes B celldependent inflammation. J Leuk Biol. 2010;88:779-89.
-
(2010)
J Leuk Biol
, vol.88
, pp. 779-89
-
-
Newell, M.K.1
Tobin, R.P.2
Cabrera, J.H.3
-
22
-
-
77950365906
-
Non-resolving inflammation
-
This is an excellent review of the critical elements that regulate the host response to human septic and sterile inflammatory processes. The mechanisms of immune and tissue-specific restoration of structure and function are examined in detail
-
Nathan C, Ding A. Non-resolving inflammation. Cell. 2010;140:871-82. This is an excellent review of the critical elements that regulate the host response to human septic and sterile inflammatory processes. The mechanisms of immune and tissue-specific restoration of structure and function are examined in detail.
-
(2010)
Cell
, vol.140
, pp. 871-82
-
-
Nathan, C.1
Ding, A.2
-
23
-
-
33644982044
-
Regulation of immune responses by t cells
-
Jiang H, Chess L. Regulation of immune responses by T cells. N Engl J Med. 2006;354(11):1166-76.
-
(2006)
N Engl J Med
, vol.354
, Issue.11
, pp. 1166-76
-
-
Jiang, H.1
Chess, L.2
-
24
-
-
77957698207
-
T cells are potent early mediators of the host response to sepsis
-
Kasten KR, Tschop J, Adediran SG, Hideman DA, Caldwell CC. T cells are potent early mediators of the host response to sepsis. Shock. 2010;34(4):327-36.
-
(2010)
Shock
, vol.34
, Issue.4
, pp. 327-36
-
-
Kasten, K.R.1
Tschop, J.2
Adediran, S.G.3
Hideman, D.A.4
Caldwell, C.C.5
-
25
-
-
78549283981
-
Novel lipid mediators promote resolution of acute inflammation: Impact of aspirin and statins
-
Spite M, Serhan CN. Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res. 2010;107:1170-84.
-
(2010)
Circ Res
, vol.107
, pp. 1170-84
-
-
Spite, M.1
Serhan, C.N.2
-
26
-
-
30044449982
-
Resolution of inflammation: The beginning programs the end
-
Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol. 2005;6:1191-7.
-
(2005)
Nat Immunol
, vol.6
, pp. 1191-7
-
-
Serhan, C.N.1
Savill, J.2
-
27
-
-
34250357688
-
Resolvin e1 and protectin d1 activate inflammation-resolution programmes
-
Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 2007; 869-74.
-
(2007)
Nature
, pp. 869-874
-
-
Schwab, J.M.1
Chiang, N.2
Arita, M.3
Serhan, C.N.4
-
28
-
-
80053593864
-
Acetylcholinesynthesizing t cells relay neural signals in a vagus nerve circuit
-
This work points out the intricate interactions between Vagus nerve signals and anti-inflammatory signals within the spleen that regulate cellular immune function
-
Ballina-Rosas M, Olofsson PS, Ochanni M, et al. Acetylcholinesynthesizing T Cells relay neural signals in a vagus nerve circuit. Science. 2011;334:98-101. This work points out the intricate interactions between Vagus nerve signals and anti-inflammatory signals within the spleen that regulate cellular immune function.
-
(2011)
Science
, vol.334
, pp. 98-101
-
-
Ballina-Rosas, M.1
Olofsson, P.S.2
Ochanni, M.3
-
29
-
-
80053604734
-
Functional innervation of hepatic inkt cells is immunosuppressive following stroke
-
This remarkable study identifies the role of the sympathetic nervous system in regulating the function of NKT cells and the important contribution of these uncommon T cells to bacterial clearance
-
Wong CHY, Jenne CN, Lee W-Y, Léger C, Kubes P. Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science. 2011;334:101-5. This remarkable study identifies the role of the sympathetic nervous system in regulating the function of NKT cells and the important contribution of these uncommon T cells to bacterial clearance.
-
(2011)
Science
, vol.334
, pp. 101-5
-
-
Wong, C.H.Y.1
Jenne, C.N.2
Lee, W.-Y.3
Léger, C.4
Kubes, P.5
-
30
-
-
79959935289
-
Affinity aphaeresis for treatment of bacteremia caused by staphylococcus aureus and/or methicillin-resistant s. Aureus (mrsa)
-
Mattsby-Baltzer I, Bergstrom T, McCrea K, et al. Affinity aphaeresis for treatment of bacteremia caused by Staphylococcus aureus and/or methicillin-resistant S. aureus (MRSA). J Microbiol Biotechnol. 2011;21(6):659-64.
-
(2011)
J Microbiol Biotechnol
, vol.21
, Issue.6
, pp. 659-64
-
-
Mattsby-Baltzer, I.1
Bergstrom, T.2
McCrea, K.3
-
31
-
-
34249296716
-
Effectiveness of polymyxin b-immobilized fiber column in sepsis: A systematic review
-
This is a well performed meta-Analysis of the randomized and non-randomized studies of the Polymyxin B immobilized filter. These results are the basis for the need for adequately powered, randomized, controlled clinical trial
-
Cruz DN, Perazella MA, Bellomo R, et al. Effectiveness of Polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care. 2007;11:R47. This is a well performed meta-Analysis of the randomized and non-randomized studies of the Polymyxin B immobilized filter. These results are the basis for the need for adequately powered, randomized, controlled clinical trial.
-
(2007)
Crit Care
, vol.11
-
-
Cruz, D.N.1
Perazella, M.A.2
Bellomo, R.3
-
32
-
-
67649219652
-
Early use of polymyxin b hemoperfusion in abdominal septic shock, the euphas randomized controlled trial
-
Cruz DN, Antonelli M, Fumagalli R, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock, the EUPHAS randomized controlled trial. JAMA. 2009;301:2445-52.
-
(2009)
JAMA
, vol.301
, pp. 2445-52
-
-
Cruz, D.N.1
Antonelli, M.2
Fumagalli, R.3
-
33
-
-
0030777121
-
Dephosphorylation of endotoxin by alkaline phophatase in vivo
-
Poelstra K, Bakker WW, Klok PA, et al. Dephosphorylation of endotoxin by alkaline phophatase in vivo. Am J Pathol. 1997;151:1163-9.
-
(1997)
Am J Pathol
, vol.151
, pp. 1163-9
-
-
Poelstra, K.1
Bakker, W.W.2
Klok, P.A.3
-
35
-
-
13644253879
-
Protection against an escherichia coli-induced sepsis by alkaline phosphatase in mice
-
Verweij WR, Bentala H, van der Vlag AH, et al. Protection against an Escherichia coli-induced sepsis by alkaline phosphatase in mice. Shock. 2004;22:174-9.
-
(2004)
Shock
, vol.22
, pp. 174-9
-
-
Verweij, W.R.1
Bentala, H.2
Van Der Vlag, A.H.3
-
36
-
-
21544480563
-
Bovine intestinal alkaline phosphatase attenuates the inflammatory response in secondary peritonitis in mice
-
Van Veen SQ, van Vliet AK, Wulferink M, et al. Bovine intestinal alkaline phosphatase attenuates the inflammatory response in secondary peritonitis in mice. Infect Immun. 2005;73:4309-14.
-
(2005)
Infect Immun
, vol.73
, pp. 4309-14
-
-
Van Veen, S.Q.1
Van Vliet, A.K.2
Wulferink, M.3
-
37
-
-
67650361713
-
Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients
-
Heemskerk S, Masereeuw R, Moesker O, et al. Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit Care Med. 2009;37:417-23.
-
(2009)
Crit Care Med
, vol.37
, pp. 417-23
-
-
Heemskerk, S.1
Masereeuw, R.2
Moesker, O.3
-
38
-
-
84856047126
-
Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: A prospective randomized double-blind placebo-controlled trial
-
This recently completed trial of alkaline phosphatase suggests that the benefit may be due to nephroprotective properties
-
Pickkers P, Heemskerk S, Schouten J, et al. Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Crit Care. 2012;16:R14. This recently completed trial of alkaline phosphatase suggests that the benefit may be due to nephroprotective properties.
-
(2012)
Crit Care
, vol.16
-
-
Pickkers, P.1
Heemskerk, S.2
Schouten, J.3
-
39
-
-
84969404981
-
Ab103, a cd28 antagonist peptide: A new therapeutic agent in a model of severe sepsis
-
Teleman D, Chung CS, Ayala A, et al. AB103, a CD28 antagonist peptide: a new therapeutic agent in a model of severe sepsis. Crit Care. 2011;15(3):35.
-
(2011)
Crit Care
, vol.15
, Issue.3
, pp. 35
-
-
Teleman, D.1
Chung, C.S.2
Ayala, A.3
-
40
-
-
33747502519
-
Safety and efficacy of affinity-purified, anti-tumor necrosis factor-Alpha, ovine fab for injection (cytofab) in severe sepsis
-
Rice TW, Wheeler AP, Morris PE, et al. Safety and efficacy of affinity-purified, anti-tumor necrosis factor-Alpha, ovine Fab for injection (CytoFab) in severe sepsis. Crit Care Med. 2006;34:2271-81.
-
(2006)
Crit Care Med
, vol.34
, pp. 2271-81
-
-
Rice, T.W.1
Wheeler, A.P.2
Morris, P.E.3
-
42
-
-
84870482137
-
-
Effect of Multiple Dose Levels of SRT2379 on Endotoxin-Induced Inflammation. Available at Accessed 11 April 2012
-
Effect of Multiple Dose Levels of SRT2379 on Endotoxin-Induced Inflammation. Available at http://clinicaltrials.gov/ct2/show/NCT01416376. Accessed 11 April 2012.
-
-
-
-
43
-
-
17644405062
-
Peroxisome proliferator-Activated receptorgamma is a new therapeutic target in sepsis and inflammation
-
Zingarelli B, Cook JA. Peroxisome proliferator-Activated receptorgamma is a new therapeutic target in sepsis and inflammation. Shock. 2005;23:393-9.
-
(2005)
Shock
, vol.23
, pp. 393-9
-
-
Zingarelli, B.1
Cook, J.A.2
-
44
-
-
33645808481
-
Peroxisome proliferatoractivated receptor-gamma antagonists gw9662 and t0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia
-
Collin M, Murch O, Thiemermann C. Peroxisome proliferatoractivated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia. Crit Care Med. 2006;34:1131-8.
-
(2006)
Crit Care Med
, vol.34
, pp. 1131-8
-
-
Collin, M.1
Murch, O.2
Thiemermann, C.3
-
45
-
-
76549084049
-
Changes in peroxisome proliferator-Activated receptor-gamma activity in children with septic shock
-
Kaplan JM, Denenberg A, Monaco M, et al. Changes in peroxisome proliferator-Activated receptor-gamma activity in children with septic shock. Intensive Care Med. 2010;36:123-30.
-
(2010)
Intensive Care Med
, vol.36
, pp. 123-30
-
-
Kaplan, J.M.1
Denenberg, A.2
Monaco, M.3
-
46
-
-
78650212702
-
Protective role of peroxisome proliferator-Activated receptor-β/in septic shock
-
Kapoor A, Shintani Y, Collino M, et al. Protective role of peroxisome proliferator-Activated receptor-β/in septic shock. Am J Respir Crit Care Med. 2010;182:1506-15.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 1506-15
-
-
Kapoor, A.1
Shintani, Y.2
Collino, M.3
-
47
-
-
84861665800
-
Drotrecogin alfa activated in adults with septic shock
-
This follow up study with recombinant human activated protein C failed to replicate improved survival in treated patients as observed in the original phase 3 trial. This drug has been taken off the market as a result of this study
-
Ranieri VM, Thompson BT, Barie PS, et al. Drotrecogin alfa activated in adults with septic shock. N Engl J Med. 2012;366:2055-64. This follow up study with recombinant human activated protein C failed to replicate improved survival in treated patients as observed in the original phase 3 trial. This drug has been taken off the market as a result of this study.
-
(2012)
N Engl J Med
, vol.366
, pp. 2055-64
-
-
Ranieri, V.M.1
Thompson, B.T.2
Barie, P.S.3
-
48
-
-
0032746547
-
The inhibitory effect of recombinant human soluble thrombomodulin on initiation and extension of coagulation-A comparison with other anticoagulants
-
Mohri M, Sugimoto E, Sata M, et al. The inhibitory effect of recombinant human soluble thrombomodulin on initiation and extension of coagulation-A comparison with other anticoagulants. Thromb Haemost. 1999;82:1687-93.
-
(1999)
Thromb Haemost
, vol.82
, pp. 1687-93
-
-
Mohri, M.1
Sugimoto, E.2
Sata, M.3
-
49
-
-
33845513582
-
Efficacy and safety of recombinant human soluble thrombomodulin (art-123) in disseminated intravascular coagulation: Results of a phase iii, randomized, double-blind clinical trial
-
Saito H, Maruyama I, Shimazaki S, et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost. 2007;5:31-41.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 31-41
-
-
Saito, H.1
Maruyama, I.2
Shimazaki, S.3
-
50
-
-
0037248345
-
Therapeutic potential of targeting the complement cascade in critical care medicine
-
Bhole D, Stahl GL. Therapeutic potential of targeting the complement cascade in critical care medicine. Crit Care Med. 2003;31(1 Suppl):S97-104.
-
(2003)
Crit Care Med
, vol.31
, Issue.1 SUPPL.
-
-
Bhole, D.1
Stahl, G.L.2
-
51
-
-
11844295677
-
Role of c5a-c5ar interaction in sepsis
-
Guo RF, Riedemann NC, Ward PA. Role of C5a-C5aR interaction in sepsis. Shock. 2004;21:1-7.
-
(2004)
Shock
, vol.21
, pp. 1-7
-
-
Guo, R.F.1
Riedemann, N.C.2
Ward, P.A.3
-
52
-
-
84867875229
-
Pathophysiology, staging and therapy of severe sepsis in baboon models
-
This recently completed animal model of sepsis elucidates a second stage in sepsis whereby organ failure may be mediated by complement activation
-
Taylor FB, Kinasewitz GT, Lupu F. Pathophysiology, staging and therapy of severe sepsis in baboon models. J Cell Mol Med. 2012;16(4):672-82. This recently completed animal model of sepsis elucidates a second stage in sepsis whereby organ failure may be mediated by complement activation.
-
(2012)
J Cell Mol Med
, vol.16
, Issue.4
, pp. 672-82
-
-
Taylor, F.B.1
Kinasewitz, G.T.2
Lupu, F.3
-
53
-
-
77955901581
-
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of escherichia coli sepsis
-
Silasi-Mansat R, Zhu H, Popescu NI, et al. Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood. 2010;116:1002-10.
-
(2010)
Blood
, vol.116
, pp. 1002-10
-
-
Silasi-Mansat, R.1
Zhu, H.2
Popescu, N.I.3
-
54
-
-
0033052453
-
Protective effects of c5a blockade in sepsis
-
Czermak BJ, Sarma V, Pierson CL, et al. Protective effects of C5a blockade in sepsis. Nat Med. 1999;5:788-92.
-
(1999)
Nat Med
, vol.5
, pp. 788-92
-
-
Czermak, B.J.1
Sarma, V.2
Pierson, C.L.3
-
55
-
-
84857570115
-
C1-esterase inhibitor infusion increases survival rates for patients with sepsis
-
Igonin AA, Protsenko DN, Gennadiy GM, et al. C1-esterase inhibitor infusion increases survival rates for patients with sepsis. Crit Care Med. 2012;40:770-7.
-
(2012)
Crit Care Med
, vol.40
, pp. 770-7
-
-
Igonin, A.A.1
Protsenko, D.N.2
Gennadiy, G.M.3
-
56
-
-
3442885900
-
Improved survival in experimental sepsis with an orally administered inhibitor of apoptosis
-
Weaver JG, Rouse MS, Steckelberg JM, Badley AD. Improved survival in experimental sepsis with an orally administered inhibitor of apoptosis. FASEB J. 2004;18:1185-91.
-
(2004)
FASEB J
, vol.18
, pp. 1185-91
-
-
Weaver, J.G.1
Rouse, M.S.2
Steckelberg, J.M.3
Badley, A.D.4
-
57
-
-
77951648850
-
Il-7 promotes t cell viability, trafficking, and functionality and improves survival in sepsis
-
Unsinger J, McGlynn M, Kasten KR, et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol. 2010;184:3768-79.
-
(2010)
J Immunol
, vol.184
, pp. 3768-79
-
-
Unsinger, J.1
McGlynn, M.2
Kasten, K.R.3
-
58
-
-
77949317183
-
Il-15 prevents apoptosis, reverses innate and adaptive immune dysfunction and improves survival in sepsis
-
201
-
Inoue S, Unsinger J, Davis CG, et al. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction and improves survival in sepsis. J Immunol. 201;184 (3):1401-1409.
-
J Immunol
, vol.184
, Issue.3
, pp. 1401-1409
-
-
Inoue, S.1
Unsinger, J.2
Davis, C.G.3
-
59
-
-
77956403940
-
Delayed administration of anti-pd-1 antibody reverses immune dysfunction and improves survival during sepsis
-
Brahmamdam P, Inoue S, Unsinger J, Chang KC, McDunn JE, Hotchkiss RS. Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol. 2010;88:233-40.
-
(2010)
J Leukoc Biol
, vol.88
, pp. 233-40
-
-
Brahmamdam, P.1
Inoue, S.2
Unsinger, J.3
Chang, K.C.4
McDunn, J.E.5
Hotchkiss, R.S.6
-
60
-
-
78649394507
-
Targeting of b and t lymphocyte associated (btla) prevents graft-versus-host disease without global immunosuppression
-
Albring JC, Sandau MM, Rapaport AS, et al. Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression. J Exp Med. 2010;207 (12):2551-9.
-
(2010)
J Exp Med
, vol.207
, Issue.12
, pp. 2551-9
-
-
Albring, J.C.1
Sandau, M.M.2
Rapaport, A.S.3
-
61
-
-
65249151257
-
Pynttttgt prototype oligonucleotide imt504, a novel effective adjuvant of the fmdv dna vaccine
-
Zhao G, Jin H, Li J, et al. PyNTTTTGT prototype oligonucleotide IMT504, a novel effective adjuvant of the FMDV DNA vaccine. Viral Immunol. 2009;22(2):131-8.
-
(2009)
Viral Immunol
, vol.22
, Issue.2
, pp. 131-8
-
-
Zhao, G.1
Jin, H.2
Li, J.3
-
62
-
-
79956225209
-
Pharmacological characterization of fe 202158, a novel, potent, selective, and short acting peptidic vasopressin v1a receptor full agonist for the treatment of vasodilatory hypotension
-
Laporte R, Kohan A, Heitzmann J, et al. Pharmacological characterization of FE 202158, a novel, potent, selective, and short acting peptidic vasopressin V1a receptor full agonist for the treatment of vasodilatory hypotension. JPET. 2011;337(3):786-96.
-
(2011)
JPET
, vol.337
, Issue.3
, pp. 786-96
-
-
Laporte, R.1
Kohan, A.2
Heitzmann, J.3
-
63
-
-
78650310959
-
Stem cells in sepsis and acute lung injury
-
An excellent review of the multiple mechanisms of action of adult human stem cells. The paper further summarizes the experience to date with adult stem cells in animal models of sepsis and acute lung injury
-
Cribbs S, Matthay MA, Martin GS. Stem cells in sepsis and acute lung injury. Crit Care Med. 2010;38:2379-85. An excellent review of the multiple mechanisms of action of adult human stem cells. The paper further summarizes the experience to date with adult stem cells in animal models of sepsis and acute lung injury.
-
(2010)
Crit Care Med
, vol.38
, pp. 2379-85
-
-
Cribbs, S.1
Matthay, M.A.2
Martin, G.S.3
-
64
-
-
77956246824
-
Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis
-
Mei SHJ, Haitsma JJ, Dos Santos CC, et al. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med. 2010;182:1047-57.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 1047-57
-
-
Mei, S.H.J.1
Haitsma, J.J.2
Dos Santos, C.C.3
-
65
-
-
84861162374
-
Human mesenchymal stem cells reduce mortality and bacteremia in gram negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
-
in press
-
Krasnodembskaya A, Samarani G, Song Y, et al. Human mesenchymal stem cells reduce mortality and bacteremia in gram negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Am J Physiol Lung Cell Mol Physiol 2012; in press.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
-
-
Krasnodembskaya, A.1
Samarani, G.2
Song, Y.3
-
66
-
-
84856158984
-
Generic atorvastatin and health care costs
-
Jackevicius CA, Chou MM, Ross JS, Shah ND, Krumholz HM. Generic atorvastatin and health care costs. N Engl J Med. 2012;366(3):201-4.
-
(2012)
N Engl J Med
, vol.366
, Issue.3
, pp. 201-4
-
-
Jackevicius, C.A.1
Chou, M.M.2
Ross, J.S.3
Shah, N.D.4
Krumholz, H.M.5
|