Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock

PLoS Biology

Volumn 9, Issue 9, 2011, Pages

  Arad, Gila ^a   Levy, Revital ^a   Nasie, Iris ^a   Hillman, Dalia ^a   Rotfogel, Ziv ^a   Barash, Uri ^a   Supper, Emmanuelle ^a   Shpilka, Tomer ^a   Minis, Adi ^a   Kaempfer, Raymond ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; GAMMA INTERFERON; HOMODIMER; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; BACTERIAL TOXIN; CYTOKINE; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL; ENTEROTOXIN F, STAPHYLOCOCCAL; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ALPHA HELIX; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; BETA STRAND; BINDING SITE; CELL SURFACE; CONTROLLED STUDY; CYTOKINE STORM; FEMALE; GENE EXPRESSION; GENE INDUCTION; HINGE REGION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN STRUCTURE; SEPTIC SHOCK; STRUCTURE ANALYSIS; T LYMPHOCYTE; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; CELLULAR IMMUNITY; CYTOLOGY; EPITOPE MAPPING; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MONONUCLEAR CELL; PROTEIN BINDING; STAPHYLOCOCCUS AUREUS; SURFACE PLASMON RESONANCE; TUMOR CELL LINE;

BACTERIA (MICROORGANISMS); MUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD28; BACTERIAL TOXINS; CELL LINE, TUMOR; CYTOKINES; ENTEROTOXINS; EPITOPE MAPPING; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION REGULATION; GENETIC VECTORS; HUMANS; IMMUNITY, CELLULAR; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SHOCK, SEPTIC; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS; SURFACE PLASMON RESONANCE;

EID: 80053319600     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001149     Document Type: Article

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