-
2
-
-
72849127046
-
A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death
-
Choi K.C., Kim S.H., Ha J.Y., Kim S.T., Son J.H. A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. Journal of Neurochemistry 2010, 112:366-376.
-
(2010)
Journal of Neurochemistry
, vol.112
, pp. 366-376
-
-
Choi, K.C.1
Kim, S.H.2
Ha, J.Y.3
Kim, S.T.4
Son, J.H.5
-
3
-
-
77957766233
-
Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells
-
Edelstein J., Hao T., Cao Q., Morales L., Rockwell P. Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells. Cellular Signalling 2011, 23:239-248.
-
(2011)
Cellular Signalling
, vol.23
, pp. 239-248
-
-
Edelstein, J.1
Hao, T.2
Cao, Q.3
Morales, L.4
Rockwell, P.5
-
4
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman M.E., Apsel B., Uotila A., Loewith R., Knight Z.A., Ruggero D., Shokat K.M. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biology 2009, 7:e38.
-
(2009)
PLoS Biology
, vol.7
-
-
Feldman, M.E.1
Apsel, B.2
Uotila, A.3
Loewith, R.4
Knight, Z.A.5
Ruggero, D.6
Shokat, K.M.7
-
5
-
-
31644439543
-
VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells
-
Feliers D., Chen X., Akis N., Choudhury G.G., Madaio M., Kasinath B.S. VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells. Kidney International 2005, 68:1648-1659.
-
(2005)
Kidney International
, vol.68
, pp. 1648-1659
-
-
Feliers, D.1
Chen, X.2
Akis, N.3
Choudhury, G.G.4
Madaio, M.5
Kasinath, B.S.6
-
6
-
-
79955751138
-
Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium
-
Harston R.K., McKillop J.C., Moschella P.C., Van Laer A., Quinones L.S., Baicu C.F., Balasubramanian S., Zile M.R., Kuppuswamy D. Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium. American Journal of Physiology - Heart and Circulatory Physiology 2011, 300:1696-1706.
-
(2011)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.300
, pp. 1696-1706
-
-
Harston, R.K.1
McKillop, J.C.2
Moschella, P.C.3
Van Laer, A.4
Quinones, L.S.5
Baicu, C.F.6
Balasubramanian, S.7
Zile, M.R.8
Kuppuswamy, D.9
-
7
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N., Sonenberg N. Upstream and downstream of mTOR. Genes and Development 2004, 18:1926-1945.
-
(2004)
Genes and Development
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
8
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
Hsu P.P., Kang S.A., Rameseder J., Zhang Y., Ottina K.A., Lim D., Peterson T.R., Choi Y., Gray N.S., Yaffe M.B., Marto J.A., Sabatini D.M. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 2011, 332:1317-1322.
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
Zhang, Y.4
Ottina, K.A.5
Lim, D.6
Peterson, T.R.7
Choi, Y.8
Gray, N.S.9
Yaffe, M.B.10
Marto, J.A.11
Sabatini, D.M.12
-
9
-
-
59749091850
-
A complex interplay between Akt, TSC2 and the two mTOR complexes
-
Huang J., Manning B.D. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochemical Society Transactions 2009, 37:217-222.
-
(2009)
Biochemical Society Transactions
, vol.37
, pp. 217-222
-
-
Huang, J.1
Manning, B.D.2
-
10
-
-
0035252894
-
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
-
Janssens V., Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochemical Journal 2001, 353:417-439.
-
(2001)
Biochemical Journal
, vol.353
, pp. 417-439
-
-
Janssens, V.1
Goris, J.2
-
11
-
-
0035853707
-
Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress
-
Kondo M., Oya-Ito T., Kumagai T., Osawa T., Uchida K. Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. Journal of Biological Chemistry 2001, 276:12076-12083.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 12076-12083
-
-
Kondo, M.1
Oya-Ito, T.2
Kumagai, T.3
Osawa, T.4
Uchida, K.5
-
12
-
-
38349190654
-
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt
-
Kuo Y.C., Huang K.Y., Yang C.H., Yang Y.S., Lee W.Y., Chiang C.W. Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. Journal of Biological Chemistry 2008, 283:1882-1892.
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 1882-1892
-
-
Kuo, Y.C.1
Huang, K.Y.2
Yang, C.H.3
Yang, Y.S.4
Lee, W.Y.5
Chiang, C.W.6
-
13
-
-
79956317900
-
Enhanced phosphatase activity attenuates alpha-Synucleinopathy in a mouse model
-
Lee K.W., Chen W., Junn E., Im J.Y., Grosso H., Sonsalla P.K., Feng X., Ray N., Fernandez J.R., Chao Y., Masliah E., Voronkov M., Braithwaite S.P., Stock J.B., Mouradian M.M. Enhanced phosphatase activity attenuates alpha-Synucleinopathy in a mouse model. Journal of Neuroscience 2011, 31:6963-6971.
-
(2011)
Journal of Neuroscience
, vol.31
, pp. 6963-6971
-
-
Lee, K.W.1
Chen, W.2
Junn, E.3
Im, J.Y.4
Grosso, H.5
Sonsalla, P.K.6
Feng, X.7
Ray, N.8
Fernandez, J.R.9
Chao, Y.10
Masliah, E.11
Voronkov, M.12
Braithwaite, S.P.13
Stock, J.B.14
Mouradian, M.M.15
-
15
-
-
56849118516
-
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
-
Nogueira V., Park Y., Chen C.C., Xu P.Z., Chen M.L., Tonic I., Unterman T., Hay N. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008, 14:458-470.
-
(2008)
Cancer Cell
, vol.14
, pp. 458-470
-
-
Nogueira, V.1
Park, Y.2
Chen, C.C.3
Xu, P.Z.4
Chen, M.L.5
Tonic, I.6
Unterman, T.7
Hay, N.8
-
16
-
-
3042572347
-
Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells
-
Riesterer O., Zingg D., Hummerjohann J., Bodis S., Pruschy M. Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells. Oncogene 2004, 23:4624-4635.
-
(2004)
Oncogene
, vol.23
, pp. 4624-4635
-
-
Riesterer, O.1
Zingg, D.2
Hummerjohann, J.3
Bodis, S.4
Pruschy, M.5
-
17
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov D.D., Ali S.M., Sengupta S., Sheen J.H., Hsu P.P., Bagley A.F., Markhard A.L., Sabatini D.M. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Molecular Cell 2006, 22:159-168.
-
(2006)
Molecular Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
18
-
-
71649104466
-
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
-
Suizu F., Hiramuki Y., Okumura F., Matsuda M., Okumura A.J., Hirata N., Narita M., Kohno T., Yokota J., Bohgaki M., Obuse C., Hatakeyama S., Obata T., Noguchi M. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Developmental Cell 2009, 17:800-810.
-
(2009)
Developmental Cell
, vol.17
, pp. 800-810
-
-
Suizu, F.1
Hiramuki, Y.2
Okumura, F.3
Matsuda, M.4
Okumura, A.J.5
Hirata, N.6
Narita, M.7
Kohno, T.8
Yokota, J.9
Bohgaki, M.10
Obuse, C.11
Hatakeyama, S.12
Obata, T.13
Noguchi, M.14
-
19
-
-
79954600448
-
Su, mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif
-
Wu Y.T., W.Ouyang A.S., Lazorchak D., Liu H.M., Shen B. Su, mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif. Journal of Biological Chemistry 2011, 286:14190-14198.
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 14190-14198
-
-
Wu, Y.T.1
W.Ouyang, A.S.2
Lazorchak, D.3
Liu, H.M.4
Shen, B.5
-
20
-
-
33745845126
-
Autophagy contributes to caspase-independent macrophage cell death
-
Xu Y., Kim S.O., Li Y., Han J. Autophagy contributes to caspase-independent macrophage cell death. Journal of Biological Chemistry 2006, 281:19179-19187.
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 19179-19187
-
-
Xu, Y.1
Kim, S.O.2
Li, Y.3
Han, J.4
-
21
-
-
77955654403
-
Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development
-
Yang W.L., Zhang X., Lin H.K. Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene 2010, 29:4493-4503.
-
(2010)
Oncogene
, vol.29
, pp. 4493-4503
-
-
Yang, W.L.1
Zhang, X.2
Lin, H.K.3
-
22
-
-
58149328523
-
Mechanism of okadaic acid-induced neuronal death and the effect of estrogens
-
Yi K.D., Covey D.F., Simpkins J.W. Mechanism of okadaic acid-induced neuronal death and the effect of estrogens. Journal of Neurochemistry 2009, 108:732-740.
-
(2009)
Journal of Neurochemistry
, vol.108
, pp. 732-740
-
-
Yi, K.D.1
Covey, D.F.2
Simpkins, J.W.3
-
23
-
-
57049094384
-
Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease
-
Yoon S.Y., Choi J.E., Kweon H.S., Choe H., Kim S.W., Hwang O., Lee H., Lee J.Y., Kim D.H. Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease. Journal of Neuroscience Research 2008, 86:3230-3239.
-
(2008)
Journal of Neuroscience Research
, vol.86
, pp. 3230-3239
-
-
Yoon, S.Y.1
Choi, J.E.2
Kweon, H.S.3
Choe, H.4
Kim, S.W.5
Hwang, O.6
Lee, H.7
Lee, J.Y.8
Kim, D.H.9
-
24
-
-
33847394119
-
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
-
Zhang H., Bajraszewski N., Wu E., Wang H., Moseman A.P., Dabora S.L., Griffin J.D., Kwiatkowski D.J. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. Journal of Clinical Investigation 2007, 117:730-738.
-
(2007)
Journal of Clinical Investigation
, vol.117
, pp. 730-738
-
-
Zhang, H.1
Bajraszewski, N.2
Wu, E.3
Wang, H.4
Moseman, A.P.5
Dabora, S.L.6
Griffin, J.D.7
Kwiatkowski, D.J.8
-
25
-
-
78650510609
-
Sabatini, mTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R., A.Efeyan D.M. Sabatini, mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Reviews Molecular Cell Biology 2011, 12:21-35.
-
(2011)
Nature Reviews Molecular Cell Biology
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
A.Efeyan, D.M.2
|