Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 5, 2011, Pages

  Harston, Rebecca K ^a   McKillop, John C ^a   Moschella, Phillip C ^a   van Laer, An ^a   Quinones, Lakeya S ^a   Baicu, Catalin F ^a   Balasubramanian, Sundaravadivel ^a   Zile, Michael R ^a,b   Kuppuswamy, Dhandapani ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Cell survival; Hypertrophy; Mammalian target of rapamycin; Signal transduction

Indexed keywords

CASPASE 3; INHIBITOR OF APOPTOSIS PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HEART PROTECTION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN VITRO STUDY; LIFESPAN; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; CALPAIN; CASPASE 3; HYPERTROPHY; IMMUNOSUPPRESSIVE AGENTS; INHIBITOR OF APOPTOSIS PROTEINS; MALE; MODELS, ANIMAL; MYOCARDIUM; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED F344; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES; UBIQUITINATION;

EID: 79955751138     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00545.2010     Document Type: Article

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