Role of generation, architecture, pH and ionic strength on successful siRNA delivery and transfection by hybrid PPV-PAMAM dendrimers

Current Medicinal Chemistry

Volumn 19, Issue 29, 2012, Pages 4929-4941

  Pavan, G M ^a   Monteagudo, S ^b   Guerra, J ^b,c   Carrion B ^b   Ocana V ^c,d   Rodriguez Lopez J ^c   Danani, A ^a   Perez Martinez F C ^b   Cena V ^c,d  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS OF SOUTHERN SWITZERLAND   (Switzerland)

^b Campus Universitario   (Spain)

^c UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Dendrimer; Ionic strength; Molecular dynamic simulation; PH; SiRNA transfection

Indexed keywords

DENDRIMER; NANOCARRIER; POLYAMIDOAMINE; POLYPHENYLENEVINYLENE DENDRIMER; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; BRAIN CELL; CELL CULTURE; DOWN REGULATION; HYBRID; IONIC STRENGTH; MOLECULAR DYNAMICS; NONHUMAN; PH; RAT; RNA BINDING; ZETA POTENTIAL;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DENDRIMERS; GENE KNOCKDOWN TECHNIQUES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NEURONS; OSMOLAR CONCENTRATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; THERMODYNAMICS; TRANSFECTION;

EID: 84870401499     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867311209024929     Document Type: Article

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