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Volumn 61, Issue 12, 2012, Pages 3285-3293

PPARδ activation protects endothelial function in diabetic mice

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; GW 1516; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 84870370269     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0117     Document Type: Article
Times cited : (61)

References (49)
  • 4
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • DOI 10.1016/S0092-8674(03)00269-1
    • Wang YX, Lee CH, Tiep S, et al. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 2003;113:159-170 (Pubitemid 36514968)
    • (2003) Cell , vol.113 , Issue.2 , pp. 159-170
    • Wang, Y.-X.1    Lee, C.-H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5    Kang, H.6    Evans, R.M.7
  • 7
    • 80755152865 scopus 로고    scopus 로고
    • Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion
    • Cohen G, Riahi Y, Shamni O, et al. Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion. Diabetes 2011;60:2830-2842
    • (2011) Diabetes , vol.60 , pp. 2830-2842
    • Cohen, G.1    Riahi, Y.2    Shamni, O.3
  • 8
    • 80052090426 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes
    • Serrano-Marco L, Rodríguez-Calvo R, El Kochairi I, et al. Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes. Diabetes 2011;60:1990-1999
    • (2011) Diabetes , vol.60 , pp. 1990-1999
    • Serrano-Marco, L.1    Rodríguez-Calvo, R.2    El Kochairi, I.3
  • 9
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity
    • DOI 10.1016/j.cmet.2008.04.002, PII S1550413108001125
    • Kang K, Reilly SM, Karabacak V, et al. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab 2008;7:485-495 (Pubitemid 351729204)
    • (2008) Cell Metabolism , vol.7 , Issue.6 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5    Hatano, B.6    Lee, C.-H.7
  • 11
    • 49649129066 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
    • Qin X, Xie X, Fan Y, et al. Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology 2008;48:432-441
    • (2008) Hepatology , vol.48 , pp. 432-441
    • Qin, X.1    Xie, X.2    Fan, Y.3
  • 12
    • 79952400627 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor delta inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice
    • Matsushita Y, Ogawa D, Wada J, et al. Activation of peroxisome proliferator-activated receptor delta inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice. Diabetes 2011; 60:960-968
    • (2011) Diabetes , vol.60 , pp. 960-968
    • Matsushita, Y.1    Ogawa, D.2    Wada, J.3
  • 14
    • 39649101196 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
    • Risérus U, Sprecher D, Johnson T, et al. Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes 2008;57:332-339
    • (2008) Diabetes , vol.57 , pp. 332-339
    • Risérus, U.1    Sprecher, D.2    Johnson, T.3
  • 17
    • 77953810264 scopus 로고    scopus 로고
    • Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress
    • Georgiadi A, Lichtenstein L, Degenhardt T, et al. Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. Circ Res 2010;106:1712-1721
    • (2010) Circ Res , vol.106 , pp. 1712-1721
    • Georgiadi, A.1    Lichtenstein, L.2    Degenhardt, T.3
  • 19
    • 48049084162 scopus 로고    scopus 로고
    • Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells
    • He T, Lu T, d'Uscio LV, Lam CF, Lee HC, Katusic ZS. Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells. Circ Res 2008;103:80-88
    • (2008) Circ Res , vol.103 , pp. 80-88
    • He, T.1    Lu, T.2    D'Uscio, L.V.3    Lam, C.F.4    Lee, H.C.5    Katusic, Z.S.6
  • 20
    • 80051470205 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-delta enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin
    • He T, Smith LA, Lu T, Joyner MJ, Katusic ZS. Activation of peroxisome proliferator-activated receptor-delta enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin. Hypertension 2011;58:287-294
    • (2011) Hypertension , vol.58 , pp. 287-294
    • He, T.1    Smith, L.A.2    Lu, T.3    Joyner, M.J.4    Katusic, Z.S.5
  • 21
    • 52149086346 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway
    • Han JK, Lee HS, Yang HM, et al. Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway. Circulation 2008;118:1021-1033
    • (2008) Circulation , vol.118 , pp. 1021-1033
    • Han, J.K.1    Lee, H.S.2    Yang, H.M.3
  • 22
    • 33745968479 scopus 로고    scopus 로고
    • Protection of endothelial survival by peroxisome proliferator-activated receptor-δ mediated 14-3-3 upregulation
    • DOI 10.1161/01.ATV.0000223875.14120.93, PII 0004360520060700000012
    • Liou JY, Lee S, Ghelani D, Matijevic-Aleksic N, Wu KK. Protection of endothelial survival by peroxisome proliferator-activated receptor-delta mediated 14-3-3 upregulation. Arterioscler Thromb Vasc Biol 2006;26:1481-1487 (Pubitemid 44288972)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.7 , pp. 1481-1487
    • Liou, J.-Y.1    Lee, S.2    Ghelani, D.3    Matijevic-Aleksic, N.4    Wu, K.K.5
  • 25
  • 27
    • 76749129634 scopus 로고    scopus 로고
    • Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway
    • Jiménez R, Sánchez M, Zarzuelo MJ, et al. Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway. J Pharmacol Exp Ther 2010;332:554-561
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 554-561
    • Jiménez, R.1    Sánchez, M.2    Zarzuelo, M.J.3
  • 28
    • 80053575772 scopus 로고    scopus 로고
    • Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats
    • Zarzuelo MJ, Jiménez R, Galindo P, et al. Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats. Hypertension 2011;58:733-743
    • (2011) Hypertension , vol.58 , pp. 733-743
    • Zarzuelo, M.J.1    Jiménez, R.2    Galindo, P.3
  • 30
    • 77951454070 scopus 로고    scopus 로고
    • Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation
    • Chan YC, Leung FP, Wong WT, et al. Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation. Arterioscler Thromb Vasc Biol 2010;30:992-999
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 992-999
    • Chan, Y.C.1    Leung, F.P.2    Wong, W.T.3
  • 31
    • 77958496539 scopus 로고    scopus 로고
    • Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension
    • Wong WT, Tian XY, Chen Y, et al. Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circ Res 2010;107:984-991
    • (2010) Circ Res , vol.107 , pp. 984-991
    • Wong, W.T.1    Tian, X.Y.2    Chen, Y.3
  • 32
    • 50349102094 scopus 로고    scopus 로고
    • Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries
    • Tang Z, Wang Y, Fan Y, Zhu Y, Chien S, Wang N. Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries. Circulation 2008;118:764-772
    • (2008) Circulation , vol.118 , pp. 764-772
    • Tang, Z.1    Wang, Y.2    Fan, Y.3    Zhu, Y.4    Chien, S.5    Wang, N.6
  • 33
    • 61949165795 scopus 로고    scopus 로고
    • AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
    • Chen Z, Peng IC, Sun W, et al. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res 2009; 104:496-505
    • (2009) Circ Res , vol.104 , pp. 496-505
    • Chen, Z.1    Peng, I.C.2    Sun, W.3
  • 34
    • 0037072826 scopus 로고    scopus 로고
    • Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells
    • Wang N, Verna L, Chen NG, et al. Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells. J Biol Chem 2002; 277:34176-34181
    • (2002) J Biol Chem , vol.277 , pp. 34176-34181
    • Wang, N.1    Verna, L.2    Chen, N.G.3
  • 36
    • 0034711278 scopus 로고    scopus 로고
    • The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in rhabdomyosarcoma-derived RD cells
    • DOI 10.1074/jbc.M005030200
    • Xu Q, Wu Z. The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in rhabdomyosarcoma-derived RD cells. J Biol Chem 2000; 275:36750-36757 (Pubitemid 32002082)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.47 , pp. 36750-36757
    • Xu, Q.1    Wu, Z.2
  • 38
    • 77951197658 scopus 로고    scopus 로고
    • The natural protective mechanism against hyperglycemia in vascular endothelial cells: Roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta
    • Riahi Y, Sin-Malia Y, Cohen G, et al. The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta. Diabetes 2010;59:808-818
    • (2010) Diabetes , vol.59 , pp. 808-818
    • Riahi, Y.1    Sin-Malia, Y.2    Cohen, G.3
  • 39
    • 0037076294 scopus 로고    scopus 로고
    • Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: Role of peroxisome proliferator- activated receptor-γ
    • DOI 10.1161/01.CIR.0000016049.86468.23
    • Diep QN, El Mabrouk M, Cohn JS, et al. Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma. Circulation 2002;105:2296-2302 (Pubitemid 34535341)
    • (2002) Circulation , vol.105 , Issue.19 , pp. 2296-2302
    • Diep, Q.N.1    Mabrouk, M.E.2    Cohn, J.S.3    Endemann, D.4    Amiri, F.5    Virdis, A.6    Neves, M.F.7    Schiffrin, E.L.8
  • 40
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit thrombin- induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
    • Delerive P, Martin-Nizard F, Chinetti G, et al. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ Res 1999;85:394-402 (Pubitemid 29409616)
    • (1999) Circulation Research , vol.85 , Issue.5 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3    Trottein, F.4    Fruchart, J.-C.5    Najib, J.6    Duriez, P.7    Staels, B.8
  • 41
    • 70350433697 scopus 로고    scopus 로고
    • Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production
    • Kleinhenz JM, Kleinhenz DJ, You S, et al. Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production. Am J Physiol Heart Circ Physiol 2009;297:H1647-H1654
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Kleinhenz, J.M.1    Kleinhenz, D.J.2    You, S.3
  • 42
    • 33847413743 scopus 로고    scopus 로고
    • Nitric oxide activation of peroxisome proliferator-activated receptor gamma through a p38 MAPK signaling pathway
    • DOI 10.1096/fj.06-6822com
    • Ptasinska A, Wang S, Zhang J, Wesley RA, Danner RL. Nitric oxide activation of peroxisome proliferator-activated receptor gamma through a p38 MAPK signaling pathway. FASEB J 2007;21:950-961 (Pubitemid 46348267)
    • (2007) FASEB Journal , vol.21 , Issue.3 , pp. 950-961
    • Ptasinska, A.1    Wang, S.2    Zhang, J.3    Wesley, R.A.4    Danner, R.L.5
  • 44
    • 33644853793 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activation with pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors
    • Campia U, Matuskey LA, Panza JA. Peroxisome proliferator-activated receptor-gamma activation with pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors. Circulation 2006;113:867-875
    • (2006) Circulation , vol.113 , pp. 867-875
    • Campia, U.1    Matuskey, L.A.2    Panza, J.A.3
  • 45
    • 18144386859 scopus 로고    scopus 로고
    • Effect of a peroxisome proliferator-activated receptor-γ agonist on myocardial blood flow in type 2 diabetes
    • DOI 10.2337/diacare.28.5.1145
    • McMahon GT, Plutzky J, Daher E, Bhattacharyya T, Grunberger G, DiCarli MF. Effect of a peroxisome proliferator-activated receptor-gamma agonist on myocardial blood flow in type 2 diabetes. Diabetes Care 2005;28:1145-1150 (Pubitemid 40616626)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1145-1150
    • McMahon, G.T.1    Plutzky, J.2    Daher, E.3    Bhattacharyya, T.4    Grunberger, G.5    DiCarli, M.F.6
  • 46
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356: 2457-2471 (Pubitemid 46919772)
    • (2007) New England Journal of Medicine , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 48
    • 0036771764 scopus 로고    scopus 로고
    • Antiapoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 signaling pathway
    • DOI 10.1016/S1097-2765(02)00646-9
    • Di-Poï N, Tan NS, Michalik L, Wahli W, Desvergne B. Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 2002;10:721-733 (Pubitemid 35335629)
    • (2002) Molecular Cell , vol.10 , Issue.4 , pp. 721-733
    • Di-Po, N.1    Tan, N.S.2    Michalik, L.3    Wahli, W.4    Desvergne, B.5
  • 49
    • 0037192764 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells
    • DOI 10.1074/jbc.M110580200
    • Zhang J, Fu M, Zhu X, et al. Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes postconfluent cell proliferation in vascular smooth muscle cells. J Biol Chem 2002;277:11505-11512 (Pubitemid 34952920)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.13 , pp. 11505-11512
    • Zhang, J.1    Fu, M.2    Zhu, X.3    Xiao, Y.4    Mou, Y.5    Zheng, H.6    Akinbami, M.A.7    Wang, Q.8    Chen, Y.E.9


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