Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Chemistry and Biology

Volumn 15, Issue 11, 2008, Pages 1149-1155

  Follis, Ariele Viacava ^a   Hammoudeh, Dalia I ^a   Wang, Huabo ^b   Prochownik, Edward V ^b,c,d   Metallo, Steven J ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

CHEMBIO

Indexed keywords

10074 G5; 10074-G5; 5 (4 ETHYLBENZYLIDENE) 2 THIOXOTHIAZOLIDIN 4 ONE; 5-(4-ETHYLBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE; MYC PROTEIN; MYC PROTEIN, HUMAN; OXADIAZOLE DERIVATIVE; THIAZOLE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION;

AMINO ACID SEQUENCE; BINDING SITES; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; OXADIAZOLES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-MYC; THIAZOLES;

EID: 56049097680     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2008.09.011     Document Type: Article

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