-
1
-
-
33749234216
-
Drugs, their targets and the nature and number of drug targets
-
Imming P., Sinning C., Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 2006, 5:821-834.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 821-834
-
-
Imming, P.1
Sinning, C.2
Meyer, A.3
-
2
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
Wells J.A., McClendon C.L. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 2007, 450:1001-1009.
-
(2007)
Nature
, vol.450
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
3
-
-
22144454687
-
Strategies for targeting protein-protein interactions with synthetic agents
-
Yin H., Hamilton A.D. Strategies for targeting protein-protein interactions with synthetic agents. Angew Chem Int Ed 2005, 44:4130-4163.
-
(2005)
Angew Chem Int Ed
, vol.44
, pp. 4130-4163
-
-
Yin, H.1
Hamilton, A.D.2
-
4
-
-
0028916599
-
A hot-spot of binding-energy in a hormone-receptor interface
-
Clackson T., Wells J.A. A hot-spot of binding-energy in a hormone-receptor interface. Science 1995, 267:383-386.
-
(1995)
Science
, vol.267
, pp. 383-386
-
-
Clackson, T.1
Wells, J.A.2
-
5
-
-
57049095821
-
Function and structure of inherently disordered proteins
-
Dunker A.K., Silman I., Uversky V.N., Sussman J.L. Function and structure of inherently disordered proteins. Curr Opin Struct Biol 2008, 18:756-764.
-
(2008)
Curr Opin Struct Biol
, vol.18
, pp. 756-764
-
-
Dunker, A.K.1
Silman, I.2
Uversky, V.N.3
Sussman, J.L.4
-
6
-
-
60349087841
-
Biophysical characterization of intrinsically disordered proteins
-
Eliezer D. Biophysical characterization of intrinsically disordered proteins. Curr Opin Struct Biol 2009, 19:23-30.
-
(2009)
Curr Opin Struct Biol
, vol.19
, pp. 23-30
-
-
Eliezer, D.1
-
8
-
-
76649114676
-
Protein dynamics and conformational disorder in molecular recognition
-
Mittag T., Kay L.E., Forman-Kay J.D. Protein dynamics and conformational disorder in molecular recognition. J Mol Recognit 2010, 23:105-116.
-
(2010)
J Mol Recognit
, vol.23
, pp. 105-116
-
-
Mittag, T.1
Kay, L.E.2
Forman-Kay, J.D.3
-
9
-
-
37749053887
-
Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions
-
Tompa P., Fuxreiter M. Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions. Trends Biochem Sci 2008, 33:2-8.
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 2-8
-
-
Tompa, P.1
Fuxreiter, M.2
-
10
-
-
48249097986
-
Intrinsically disordered proteins in human diseases: introducing the D2 concept
-
Uversky V.N., Oldfield C.J., Dunker A.K. Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu Rev Biophys 2008, 37:215-246.
-
(2008)
Annu Rev Biophys
, vol.37
, pp. 215-246
-
-
Uversky, V.N.1
Oldfield, C.J.2
Dunker, A.K.3
-
12
-
-
14644435825
-
Intrinsically unstructured proteins and their functions
-
Dyson H.J., Wright P.E. Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol 2005, 6:197-208.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 197-208
-
-
Dyson, H.J.1
Wright, P.E.2
-
13
-
-
67649635978
-
Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity
-
Vavouri T., Semple J.I., Garcia-Verdugo R., Lehner B. Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Cell 2009, 138:198-208.
-
(2009)
Cell
, vol.138
, pp. 198-208
-
-
Vavouri, T.1
Semple, J.I.2
Garcia-Verdugo, R.3
Lehner, B.4
-
14
-
-
57149116929
-
Tight regulation of unstructured proteins: from transcript synthesis to protein degradation
-
Gsponer J., Futschik M.E., Teichmann S.A., Babu M.M. Tight regulation of unstructured proteins: from transcript synthesis to protein degradation. Science 2008, 322:1365-1368.
-
(2008)
Science
, vol.322
, pp. 1365-1368
-
-
Gsponer, J.1
Futschik, M.E.2
Teichmann, S.A.3
Babu, M.M.4
-
15
-
-
68749093787
-
Predicting intrinsic disorder in proteins: an overview
-
He B., Wang K.J., Liu Y.L., Xue B., Uversky V.N., Dunker A.K. Predicting intrinsic disorder in proteins: an overview. Cell Res 2009, 19:929-949.
-
(2009)
Cell Res
, vol.19
, pp. 929-949
-
-
He, B.1
Wang, K.J.2
Liu, Y.L.3
Xue, B.4
Uversky, V.N.5
Dunker, A.K.6
-
16
-
-
34250815165
-
Characterization of molecular recognition features, MoRFs, and their binding partners
-
Vacic V., Oldfield C.J., Mohan A., Radivojac P., Cortese M.S., Uversky V.N., Dunker A.K. Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res 2007, 6:2351-2366.
-
(2007)
J Proteome Res
, vol.6
, pp. 2351-2366
-
-
Vacic, V.1
Oldfield, C.J.2
Mohan, A.3
Radivojac, P.4
Cortese, M.S.5
Uversky, V.N.6
Dunker, A.K.7
-
17
-
-
36749037699
-
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments
-
Cheng Y.G., Oldfield C.J., Meng J.W., Romero P., Uversky V.N., Dunker A.K. Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry 2007, 46:13468-13477.
-
(2007)
Biochemistry
, vol.46
, pp. 13468-13477
-
-
Cheng, Y.G.1
Oldfield, C.J.2
Meng, J.W.3
Romero, P.4
Uversky, V.N.5
Dunker, A.K.6
-
18
-
-
67049119327
-
Prediction of protein binding regions in disordered proteins
-
Meszaros B., Simon I., Dosztanyi Z. Prediction of protein binding regions in disordered proteins. PLoS Comput Biol 2009, 5:e1000376.
-
(2009)
PLoS Comput Biol
, vol.5
-
-
Meszaros, B.1
Simon, I.2
Dosztanyi, Z.3
-
19
-
-
23144464363
-
Transcriptional regulation and transformation by MYC proteins
-
Adhikary S., Eilers M. Transcriptional regulation and transformation by MYC proteins. Nat Rev Mol Cell Biol 2005, 6:635-645.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 635-645
-
-
Adhikary, S.1
Eilers, M.2
-
20
-
-
0034724389
-
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
-
Coller H.A., Grandori C., Tamayo P., Colbert T., Lander E.S., Eisenman R.N., Golub T.R. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A 2000, 97:3260-3265.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3260-3265
-
-
Coller, H.A.1
Grandori, C.2
Tamayo, P.3
Colbert, T.4
Lander, E.S.5
Eisenman, R.N.6
Golub, T.R.7
-
21
-
-
0032905924
-
C-Myc target genes involved in cell growth, apoptosis, and metabolism
-
Dang C.V. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999, 19:1-11.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1-11
-
-
Dang, C.V.1
-
22
-
-
0025763419
-
Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
-
Blackwood E.M., Eisenman R.N. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 1991, 251:1211-1217.
-
(1991)
Science
, vol.251
, pp. 1211-1217
-
-
Blackwood, E.M.1
Eisenman, R.N.2
-
23
-
-
0037462459
-
X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors
-
Nair S.K., Burley S.K. X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Cell 2003, 112:193-205.
-
(2003)
Cell
, vol.112
, pp. 193-205
-
-
Nair, S.K.1
Burley, S.K.2
-
24
-
-
0033551374
-
MYC oncogenes and human neoplastic disease
-
Nesbit C.E., Tersak J.M., Prochownik E.V. MYC oncogenes and human neoplastic disease. Oncogene 1999, 18:3004-3016.
-
(1999)
Oncogene
, vol.18
, pp. 3004-3016
-
-
Nesbit, C.E.1
Tersak, J.M.2
Prochownik, E.V.3
-
25
-
-
53349103292
-
Modelling Myc inhibition as a cancer therapy
-
Soucek L., Whitfield J., Martins C.P., Finch A.J., Murphy D.J., Sodir N.M., Karnezis A.N., Swigart L.B., Nasi S., Evan G.I. Modelling Myc inhibition as a cancer therapy. Nature 2008, 455:679-683.
-
(2008)
Nature
, vol.455
, pp. 679-683
-
-
Soucek, L.1
Whitfield, J.2
Martins, C.P.3
Finch, A.J.4
Murphy, D.J.5
Sodir, N.M.6
Karnezis, A.N.7
Swigart, L.B.8
Nasi, S.9
Evan, G.I.10
-
26
-
-
27544456436
-
Cancer therapeutics: targeting the dark side of Myc
-
Ponzielli R., Katz S., Barsyte-Lovejoy D., Penn L.Z. Cancer therapeutics: targeting the dark side of Myc. Eur J Cancer 2005, 41:2485-2501.
-
(2005)
Eur J Cancer
, vol.41
, pp. 2485-2501
-
-
Ponzielli, R.1
Katz, S.2
Barsyte-Lovejoy, D.3
Penn, L.Z.4
-
27
-
-
1842790378
-
C-Myc as a therapeutic target in cancer
-
Prochownik E.V. c-Myc as a therapeutic target in cancer. Expert Rev Anticancer Ther 2004, 4:289-302.
-
(2004)
Expert Rev Anticancer Ther
, vol.4
, pp. 289-302
-
-
Prochownik, E.V.1
-
28
-
-
33748192942
-
The Myc oncoprotein as a therapeutic target for human cancer
-
Vita M., Henriksson M. The Myc oncoprotein as a therapeutic target for human cancer. Sem Cancer Biol 2006, 16:318-330.
-
(2006)
Sem Cancer Biol
, vol.16
, pp. 318-330
-
-
Vita, M.1
Henriksson, M.2
-
29
-
-
56049097680
-
Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules
-
Follis A.V., Hammoudeh D.I., Wang H.B., Prochownik E.V., Metallo S.J. Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules. Chem Biol 2008, 15:1149-1155.
-
(2008)
Chem Biol
, vol.15
, pp. 1149-1155
-
-
Follis, A.V.1
Hammoudeh, D.I.2
Wang, H.B.3
Prochownik, E.V.4
Metallo, S.J.5
-
30
-
-
67650523478
-
Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc
-
Hammoudeh D.I., Follis A.V., Prochownik E.V., Metallo S.J. Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc. J Am Chem Soc 2009, 131:7390-7401.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 7390-7401
-
-
Hammoudeh, D.I.1
Follis, A.V.2
Prochownik, E.V.3
Metallo, S.J.4
-
31
-
-
0037133575
-
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
-
Berg T., Cohen S.B., Desharnais J., Sonderegger C., Maslyar D.J., Goldberg J., Boger D.L., Vogt P.K. Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Proc Natl Acad Sci U S A 2002, 99:3830-3835.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 3830-3835
-
-
Berg, T.1
Cohen, S.B.2
Desharnais, J.3
Sonderegger, C.4
Maslyar, D.J.5
Goldberg, J.6
Boger, D.L.7
Vogt, P.K.8
-
32
-
-
71749101643
-
Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation
-
Shi J., Stover J.S., Whitby L.R., Vogt P.K., Boger D.L. Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation. Bioorg Med Chem Lett 2009, 19:6038-6041.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 6038-6041
-
-
Shi, J.1
Stover, J.S.2
Whitby, L.R.3
Vogt, P.K.4
Boger, D.L.5
-
33
-
-
0142057146
-
Low molecular weight inhibitors of Myc-Max interaction and function
-
Yin X., Giap C., Lazo J.S., Prochownik E.V. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 2003, 22:6151-6159.
-
(2003)
Oncogene
, vol.22
, pp. 6151-6159
-
-
Yin, X.1
Giap, C.2
Lazo, J.S.3
Prochownik, E.V.4
-
34
-
-
34748867198
-
Improved low molecular weight Myc-Max inhibitors
-
Wang H., Hammoudeh D.I., Follis A.V., Reese B.E., Lazo J.S., Metallo S.J., Prochownik E.V. Improved low molecular weight Myc-Max inhibitors. Mol Cancer Ther 2007, 6:2399-2408.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2399-2408
-
-
Wang, H.1
Hammoudeh, D.I.2
Follis, A.V.3
Reese, B.E.4
Lazo, J.S.5
Metallo, S.J.6
Prochownik, E.V.7
-
35
-
-
64349094802
-
Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model
-
Mustata G., Follis A.V., Hammoudeh D.I., Metallo S.J., Wang H.B., Prochownik E.V., Lazo J.S., Bahar I. Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model. J Med Chem 2009, 52:1247-1250.
-
(2009)
J Med Chem
, vol.52
, pp. 1247-1250
-
-
Mustata, G.1
Follis, A.V.2
Hammoudeh, D.I.3
Metallo, S.J.4
Wang, H.B.5
Prochownik, E.V.6
Lazo, J.S.7
Bahar, I.8
-
36
-
-
46449120133
-
Induced disorder in protein-ligand complexes as a drug-design strategy
-
Crespo A., Fernandez A. Induced disorder in protein-ligand complexes as a drug-design strategy. Mol Pharmacol 2008, 5:430-437.
-
(2008)
Mol Pharmacol
, vol.5
, pp. 430-437
-
-
Crespo, A.1
Fernandez, A.2
-
37
-
-
64849113665
-
Trapping moving targets with small molecules
-
Lee G.M., Craik C.S. Trapping moving targets with small molecules. Science 2009, 324:213-215.
-
(2009)
Science
, vol.324
, pp. 213-215
-
-
Lee, G.M.1
Craik, C.S.2
-
38
-
-
34347235156
-
Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins
-
Hilser V.J., Thompson E.B. Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins. Proc Natl Acad Sci U S A 2007, 104:8311-8315.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 8311-8315
-
-
Hilser, V.J.1
Thompson, E.B.2
-
39
-
-
33644762865
-
A credit-card library approach for disrupting protein-protein interactions
-
Xu Y., Shi J., Yamamoto N., Moss J.A., Vogt P.K., Janda K.D. A credit-card library approach for disrupting protein-protein interactions. Bioorg Med Chem 2006, 14:2660-2673.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 2660-2673
-
-
Xu, Y.1
Shi, J.2
Yamamoto, N.3
Moss, J.A.4
Vogt, P.K.5
Janda, K.D.6
-
40
-
-
33746239002
-
Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules
-
Kiessling A., Sperl B., Hollis A., Eick D., Berg T. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol 2006, 13:745-751.
-
(2006)
Chem Biol
, vol.13
, pp. 745-751
-
-
Kiessling, A.1
Sperl, B.2
Hollis, A.3
Eick, D.4
Berg, T.5
-
41
-
-
42149091567
-
Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]-pyrimidine
-
Kiessling A., Wiesinger R., Sperl B., Berg T. Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]-pyrimidine. ChemMedChem 2007, 2:627-630.
-
(2007)
ChemMedChem
, vol.2
, pp. 627-630
-
-
Kiessling, A.1
Wiesinger, R.2
Sperl, B.3
Berg, T.4
-
42
-
-
56149112178
-
Capnellenes from the soft coral Dendronephthya rubeola
-
Grote D., Hanel F., Dahse H.M., Seifert K. Capnellenes from the soft coral Dendronephthya rubeola. Chem Biodivers 2008, 5:1683-1693.
-
(2008)
Chem Biodivers
, vol.5
, pp. 1683-1693
-
-
Grote, D.1
Hanel, F.2
Dahse, H.M.3
Seifert, K.4
-
43
-
-
69549124720
-
Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function
-
Jiang H., Bower K.E., Beuscher A.E., Zhou B., Bobkov A.A., Olson A.J., Vogt P.K. Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function. Mol Pharmacol 2009, 76:491-502.
-
(2009)
Mol Pharmacol
, vol.76
, pp. 491-502
-
-
Jiang, H.1
Bower, K.E.2
Beuscher, A.E.3
Zhou, B.4
Bobkov, A.A.5
Olson, A.J.6
Vogt, P.K.7
-
44
-
-
33646551232
-
Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation
-
Mo H., Henriksson M. Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation. Proc Natl Acad Sci U S A 2006, 103:6344-6349.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 6344-6349
-
-
Mo, H.1
Henriksson, M.2
-
45
-
-
33749599777
-
Myc overexpression enhances apoptosis induced by small molecules
-
Mo H., Vita M., Crespin M., Henriksson M. Myc overexpression enhances apoptosis induced by small molecules. Cell Cycle 2006, 5:2191-2194.
-
(2006)
Cell Cycle
, vol.5
, pp. 2191-2194
-
-
Mo, H.1
Vita, M.2
Crespin, M.3
Henriksson, M.4
-
46
-
-
54549098184
-
Target flexibility: an emerging consideration in drug discovery and design
-
Cozzini P., Kellogg G.E., Spyrakis F., Abraham D.J., Costantino G., Emerson A., Fanelli F., Gohlke H., Kuhn L.A., Morris G.M., et al. Target flexibility: an emerging consideration in drug discovery and design. J Med Chem 2008, 51:6237-6255.
-
(2008)
J Med Chem
, vol.51
, pp. 6237-6255
-
-
Cozzini, P.1
Kellogg, G.E.2
Spyrakis, F.3
Abraham, D.J.4
Costantino, G.5
Emerson, A.6
Fanelli, F.7
Gohlke, H.8
Kuhn, L.A.9
Morris, G.M.10
-
47
-
-
45149105232
-
Substrate-targeting gamma-secretase modulators
-
Kukar T.L., Ladd T.B., Bann M.A., Fraering P.C., Narlawar R., Maharvi G.M., Healy B., Chapman R., Welzel A.T., Price R.W., et al. Substrate-targeting gamma-secretase modulators. Nature 2008, 453:925-929.
-
(2008)
Nature
, vol.453
, pp. 925-929
-
-
Kukar, T.L.1
Ladd, T.B.2
Bann, M.A.3
Fraering, P.C.4
Narlawar, R.5
Maharvi, G.M.6
Healy, B.7
Chapman, R.8
Welzel, A.T.9
Price, R.W.10
-
48
-
-
70349249705
-
Structural disorder in amyloid fibrils: its implication in dynamic interactions of proteins
-
Tompa P. Structural disorder in amyloid fibrils: its implication in dynamic interactions of proteins. FEBS J 2009, 276:5406-5415.
-
(2009)
FEBS J
, vol.276
, pp. 5406-5415
-
-
Tompa, P.1
-
49
-
-
69149103558
-
Intrinsic disorder in proteins associated with neurodegenerative diseases
-
Uversky V.N. Intrinsic disorder in proteins associated with neurodegenerative diseases. Front Biosci 2009, 14:5188-5238.
-
(2009)
Front Biosci
, vol.14
, pp. 5188-5238
-
-
Uversky, V.N.1
-
50
-
-
0036388876
-
Inhibition of proteolysis and other posttranslational modifications with substrate-targeted inhibitors
-
Kodadek T. Inhibition of proteolysis and other posttranslational modifications with substrate-targeted inhibitors. Biopolymers 2002, 66:134-140.
-
(2002)
Biopolymers
, vol.66
, pp. 134-140
-
-
Kodadek, T.1
-
51
-
-
33747784240
-
The development of molecular clamps as drugs
-
Weiss S.T., McIntyre N.R., McLaughlin M.L., Merkler D.J. The development of molecular clamps as drugs. Drug Discov Today 2006, 11:819-824.
-
(2006)
Drug Discov Today
, vol.11
, pp. 819-824
-
-
Weiss, S.T.1
McIntyre, N.R.2
McLaughlin, M.L.3
Merkler, D.J.4
-
52
-
-
33847783298
-
Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins
-
Xie H.B., Vucetic S., Iakoucheva L.M., Oldfield C.J., Dunker A.K., Obradovic Z., Uversky V.N. Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res 2007, 6:1917-1932.
-
(2007)
J Proteome Res
, vol.6
, pp. 1917-1932
-
-
Xie, H.B.1
Vucetic, S.2
Iakoucheva, L.M.3
Oldfield, C.J.4
Dunker, A.K.5
Obradovic, Z.6
Uversky, V.N.7
-
53
-
-
6344280796
-
Recombinant EWS-FLI1 oncoprotein activates transcription
-
Uren A., Tcherkasskaya O., Toretsky J.A. Recombinant EWS-FLI1 oncoprotein activates transcription. Biochemistry 2004, 43:13579-13589.
-
(2004)
Biochemistry
, vol.43
, pp. 13579-13589
-
-
Uren, A.1
Tcherkasskaya, O.2
Toretsky, J.A.3
-
54
-
-
67650447477
-
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
-
Erkizan H.V., Kong Y.L., Merchant M., Schlottmann S., Barber-Rotenberg J.S., Yuan L.S., Abaan O.D., Chou T.H., Dakshanamurthy S., Brown M.L., et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med 2009, 15:750-758.
-
(2009)
Nat Med
, vol.15
, pp. 750-758
-
-
Erkizan, H.V.1
Kong, Y.L.2
Merchant, M.3
Schlottmann, S.4
Barber-Rotenberg, J.S.5
Yuan, L.S.6
Abaan, O.D.7
Chou, T.H.8
Dakshanamurthy, S.9
Brown, M.L.10
-
55
-
-
0034787192
-
Identification of small molecule binding sites within proteins using phage display technology
-
Rodi D.J., Agoston G.E., Manon R., Lapcevich R., Green S.J., Makowski L. Identification of small molecule binding sites within proteins using phage display technology. Comb Chem High Throughput Screen 2001, 4:553-572.
-
(2001)
Comb Chem High Throughput Screen
, vol.4
, pp. 553-572
-
-
Rodi, D.J.1
Agoston, G.E.2
Manon, R.3
Lapcevich, R.4
Green, S.J.5
Makowski, L.6
-
56
-
-
0033534641
-
Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein
-
Rodi D.J., Janes R.W., Sanganee H.J., Holton R.A., Wallace B.A., Makowski L. Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein. J Mol Biol 1999, 285:197-203.
-
(1999)
J Mol Biol
, vol.285
, pp. 197-203
-
-
Rodi, D.J.1
Janes, R.W.2
Sanganee, H.J.3
Holton, R.A.4
Wallace, B.A.5
Makowski, L.6
-
57
-
-
36849030422
-
Screening of paclitaxel-binding molecules from a library of random peptides displayed on t7 phage particles using paclitaxel-photoimmobilized resin
-
Aoki S., Morohashi K., Sunoki T., Kuramochi K., Kobayashi S., Sugawara F. Screening of paclitaxel-binding molecules from a library of random peptides displayed on t7 phage particles using paclitaxel-photoimmobilized resin. Bioconjugate Chem 2007, 18:1981-1986.
-
(2007)
Bioconjugate Chem
, vol.18
, pp. 1981-1986
-
-
Aoki, S.1
Morohashi, K.2
Sunoki, T.3
Kuramochi, K.4
Kobayashi, S.5
Sugawara, F.6
-
58
-
-
20444364906
-
Identification of a drug target motif: an anti-tumor drug NK109 interacts with a PNxxxxP
-
Morohashi K., Yoshino A., Yoshimori A., Saito S., Tanuma S., Sakaguchi K., Sugawara F. Identification of a drug target motif: an anti-tumor drug NK109 interacts with a PNxxxxP. Biochem Pharmacol 2005, 70:37-46.
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 37-46
-
-
Morohashi, K.1
Yoshino, A.2
Yoshimori, A.3
Saito, S.4
Tanuma, S.5
Sakaguchi, K.6
Sugawara, F.7
-
59
-
-
57649155506
-
Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device
-
Nishiyama K., Takakusagi Y., Kusayanagi T., Matsumoto Y., Habu S., Kuramochi K., Sugawara F., Sakaguchi K., Takahashi H., Natsugari H., et al. Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device. Bioorg Med Chem 2009, 17:195-202.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 195-202
-
-
Nishiyama, K.1
Takakusagi, Y.2
Kusayanagi, T.3
Matsumoto, Y.4
Habu, S.5
Kuramochi, K.6
Sugawara, F.7
Sakaguchi, K.8
Takahashi, H.9
Natsugari, H.10
-
60
-
-
25144477048
-
Camptothecin binds to a synthetic peptide identified by a T7 phage display screen
-
Takakusagi Y., Kobayashi S., Sugawara F. Camptothecin binds to a synthetic peptide identified by a T7 phage display screen. Bioorg Med Chem Lett 2005, 15:4850-4853.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 4850-4853
-
-
Takakusagi, Y.1
Kobayashi, S.2
Sugawara, F.3
-
61
-
-
33646570598
-
Small molecule inhibitors of alpha-synuclein filament assembly
-
Masuda M., Suzuki N., Taniguchi S., Oikawa T., Nonaka T., Iwatsubo T., Hisanaga S., Goedert M., Hasegawa M. Small molecule inhibitors of alpha-synuclein filament assembly. Biochemistry 2006, 45:6085-6094.
-
(2006)
Biochemistry
, vol.45
, pp. 6085-6094
-
-
Masuda, M.1
Suzuki, N.2
Taniguchi, S.3
Oikawa, T.4
Nonaka, T.5
Iwatsubo, T.6
Hisanaga, S.7
Goedert, M.8
Hasegawa, M.9
-
62
-
-
77449112107
-
Detergent-like interaction of Congo red with the amyloid beta peptide
-
Lendel C., Bolognesi B., Wahlstrom A., Dobson C.M., Graslund A. Detergent-like interaction of Congo red with the amyloid beta peptide. Biochemistry 2010, 49:1358-1360.
-
(2010)
Biochemistry
, vol.49
, pp. 1358-1360
-
-
Lendel, C.1
Bolognesi, B.2
Wahlstrom, A.3
Dobson, C.M.4
Graslund, A.5
-
63
-
-
39349094523
-
Small-molecule aggregates inhibit amyloid polymerization
-
Feng B.Y., Toyama B.H., Wille H., Colby D.W., Collins S.R., May B.C.H., Prusiner S.B., Weissman J., Shoichet B.K. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol 2008, 4:197-199.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 197-199
-
-
Feng, B.Y.1
Toyama, B.H.2
Wille, H.3
Colby, D.W.4
Collins, S.R.5
May, B.C.H.6
Prusiner, S.B.7
Weissman, J.8
Shoichet, B.K.9
-
64
-
-
56249101714
-
Malleable machines take shape in eukaryotic transcriptional regulation
-
Fuxreiter M., Tompa P., Simon I., Uversky V.N., Hansen J.C., Asturias F.J. Malleable machines take shape in eukaryotic transcriptional regulation. Nat Chem Biol 2008, 4:728-737.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 728-737
-
-
Fuxreiter, M.1
Tompa, P.2
Simon, I.3
Uversky, V.N.4
Hansen, J.C.5
Asturias, F.J.6
-
65
-
-
68949119585
-
The topology of drug-target interaction networks: implicit dependence on drug properties and target families
-
Mestres J., Gregori-Puigjane E., Valverde S., Sole R.V. The topology of drug-target interaction networks: implicit dependence on drug properties and target families. Mol BioSyst 2009, 5:1051-1057.
-
(2009)
Mol BioSyst
, vol.5
, pp. 1051-1057
-
-
Mestres, J.1
Gregori-Puigjane, E.2
Valverde, S.3
Sole, R.V.4
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