Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc

Journal of the American Chemical Society

Volumn 131, Issue 21, 2009, Pages 7390-7401

  Hammoudeh, Dalia I ^a   Follis, Ariele Viacava ^a   Prochownik, Edward V ^b,c,d   Metallo, Steven J ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIXES; CIRCULAR DICHROISM; CONFORMATIONAL CHANGE; DIMERIC COMPLEXES; DRUG DISCOVERY; FLUORESCENCE POLARIZATION; GENERIC APPROACH; LEUCINE ZIPPERS; ONCOPROTEIN; PROTEIN-PROTEIN INTERACTIONS; SMALL MOLECULES; SMALL-MOLECULE BINDINGS; SMALL-MOLECULE INHIBITORS; STRUCTURAL CHANGE;

AMINES; AMINO ACIDS; BINDING ENERGY; DICHROISM; DIMERIZATION; MOLECULES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC ACIDS; TRANSCRIPTION FACTORS;

BINDING SITES;

MYC PROTEIN; MYC PROTEIN INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; 10074 G5; 10074-G5; OXADIAZOLE DERIVATIVE;

ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONTROLLED STUDY; FLUORESCENCE POLARIZATION; GENE LOCUS; GENE REPRESSION; GENE SEQUENCE; NUCLEAR MAGNETIC RESONANCE; ONCOGENE C MYC; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RECEPTOR BLOCKING; DRUG ANTAGONISM; DRUG DEVELOPMENT; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DRUG DISCOVERY; OXADIAZOLES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MYC; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67650523478     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja900616b     Document Type: Article

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