Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

Journal of Medicinal Chemistry

Volumn 51, Issue 24, 2008, Pages 8012-8018

  Jiang, Jian Kang ^a   Ghoreschi, Kamran ^b   Deflorian, Francesca ^b   Chen, Zhi ^b   Perreira, Melissa ^a   Pesu, Marko ^b   Smith, Jeremy ^c   Nguyen, Dac Trung ^a   Liu, Eric H ^b   Leister, William ^a   Costanzi, Stefano ^b   O'Shea, John J ^b   Thomas, Craig J ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c Kelly Services   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; JANUS KINASE 2; JANUS KINASE 3; STAT5 PROTEIN;

ARTICLE; BINDING AFFINITY; CHIRALITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; ENANTIOMER; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; JANUS KINASE 2; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONTE CARLO METHOD; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRIMIDINES; PYRROLES; STEREOISOMERISM;

EID: 58149092616     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801142b     Document Type: Article

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