Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 4661-4677

  Li, Wei ^a,b   Li, Huafei ^a   Li, Jinfeng ^a   Wang, Huajing ^a   Zhao, He ^a   Zhang, Li ^a   Xia, Yu ^a   Ye, Zengwei ^a   Gao, Jie ^a,b   Dai, Jianxin ^a,b,c   Wang, Hao ^a,b,c   Guo, Yajun ^a,b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Engineering Research Center for Antibody Medicine   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Block copolymer; Gene transfection; Intra tumor accumulation; Nano vesicle; Serum stability

Indexed keywords

COPOLYMER; DEOXYRIBONUCLEASE I; ENHANCED GREEN FLUORESCENT PROTEIN; NANOCARRIER; PLASMID DNA; POLY(N BUTYLMETHACRYLATE) B POLY(N ACRYLOYLMORPHOLINE); POLYETHYLENEIMINE; QUANTUM DOT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG SAFETY; ENZYME DEGRADATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; KIDNEY TUBULE EPITHELIUM; LIGHT SCATTERING; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; POLYMERIZATION; REPORTER GENE; SOLID TUMOR; TRANSMISSION ELECTRON MICROSCOPY;

ACRYLIC RESINS; CRYSTALLIZATION; DNA; HEK293 CELLS; HEP G2 CELLS; HUMANS; NANOCAPSULES; NEOPLASMS, EXPERIMENTAL; POLYMETHACRYLIC ACIDS; TRANSFECTION;

BOVINAE;

EID: 84870322730     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S34675     Document Type: Article

References (53)

1. Putnam D. Polymers for gene delivery across length scales. Nat Mat. 2006;5:439-451.
2. Friedmann T. Human gene therapy-an immature genie, but certainly out of the bottle. Nat Med. 1996;2(2):144-147.
3. Pack DW, Hoffman AS, Pun S, Stayton PS. Design and development of polymers for gene delivery. Nat Rev Drug Discov. 2005;4(7): 581-593.
4. Crystal RG. Transfer of genes to humans: early lessons and obstacles to success. Science. 1995;270(5235):404-410.
5. Escoffre JM, Portet T, Favard C, Teissié J, Dean DS, Rols MP. Electromediated formation of DNA complexes with cell membranes and its consequences for gene delivery. Biochim Biophys Acta. 2011;1808(6):1538-1543.
6. Check E. A Tragic setback. Nature. 2002;420(6912):116-118.
7. Boussif O, Lezoualc'h F, Zanta MA, etal. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A. 1995;92(16):7297-7301.
8. Park TG, Jeong JH, Kim SW. Current status of polymeric gene delivery systems. Adv Drug Deliv Rev. 2006;58(4):467-486.
9. Guo X, Huang L. Recent advances in nonviral vectors for gene delivery. Acc Chem Res. 2012;45(7):971-979.
10. Un K, Kawakami S, Suzuki R, Maruyama K, Yamashita F, Hashida M. Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy. Biomaterials. 2010;31(30): 7813-7826.
11. Männistö M, Vanderkerken S, Toncheva V, etal. Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery. J Control Release. 2002;83(1):169-182.
12. Leong KW, Mao HQ, Truong-Le VL, Roy K, Walsh SM, August JT. DNA-polycation nanospheres as non-viral gene delivery vehicles. J Control Release. 1998;53(1-3):183-193.
13. Moghimi SM, Symonds P, Murray JC, Hunter AC, Debska G, Szewczyk A. A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Mol Ther. 2005;11(6):990-995.
14. Germershaus O, Neu M, Behe M, Kissel T. HER2 targeted polyplexes: the effect of polyplex composition and conjugation chemistry on in vitro and in vivo characteristics. Bioconjug Chem. 2008;19(1):244-253.
15. Breunig M, Lungwitz U, Liebl R, Goepferich A. Breaking up the correlation between efficacy and toxicity for nonviral gene delivery. Proc Natl Acad Sci U S A. 2007;104(36):14454-14459.
16. Ogris M, Brunner S, Schüller S, Kircheis R, Wagner E. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 1999;6(4):595-605.
17. Neu M, Fischer D, Kissel T. Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. J Gene Med. 2005;7(8):992-1009.
18. Deng J, Wen Y, Wang C, etal. Efficient intracellular gene delivery using the formulation composed of poly (L-glutamic acid) grafted polyethylenimine and histone. Pharm Res. 2011;28(4):812-826.
19. Cook SE, Park IK, Kim EM, etal. Galactosylated polyethylenimine-graft-poly(vinyl pyrrolidone) as a hepatocyte-targeting gene carrier. J Control Release. 2005;105(1-2):151-163.
20. Mastrobattista E, van der Aa MA, Hennink WE, Crommelin DJ. Artificial viruses: a nanotechnological approach to gene delivery. Nat Rev Drug Discov. 2006;5(2):115-121.
21. Edinger D, Wagner E. Bioresponsive polymers for the delivery of therapeutic nucleic acids. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011;3(1):33-46.
22. Wagner E. Strategies to improve DNA polyplexes for in vivo gene transfer: will "artificial viruses" be the answer? Pharm Res. 2004;21(1): 8-14.
23. Discher DE, Eisenberg A. Polymer vesicles. Science. 2002;297(5583): 967-973.
24. Lemieux P, Vinogradov SV, Gebhart CL, etal. Block and graft copolymers and nanogel copolymer networks for DNA delivery into cell. J Drug Target. 2000;8(2):91-105.
25. Thomas M, Ge Q, Lu JJ, Chen J, Klibanov AM. Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharm Res. 2005;22(3): 373-380.
26. Zhong Z, Feijen J, Lok MC, etal. Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, characterization, and in vitro gene transfer properties. Biomacromolecules. 2005;6(6):3440-3448.
27. Kwon G, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K. Block copolymer micelles for drug delivery: loading and release of doxorubicin. J Control Release. 1997;48(2-3):195-201.
28. Nakayama M, Okano T, Miyazaki T, Kohori F, Sakai K, Yokoyama M. Molecular design of biodegradable polymeric micelles for temperature-responsive drug release. J Control Release. 2006;115(1):46-56.
29. Moad G, Mayadunne RT, Rizzardo E, Skidmore M, Thang SH. Synthesis of novel architectures by radical polymerization with reversible addition fragmentation chain transfer (RAFT polymerization). Macromol Symp. 2003;192(1):1-12.
30. Nagarajan R. Molecular packing parameter and surfactant self-assembly: the neglected role of the surfactant tail. Langmuir. 2002;18(1):31-38.
31. Li W, Li J, Gao J, etal. The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors. Biomaterials. 2011;32(15):3832-3844.
32. Nakayama M, Okano T. Unique thermoresponsive polymeric micelle behavior via cooperative polymer corona phase transitions. Macromolecules. 2008;41(3):504-507.
33. Li W, Nakayama M, Okano T. Effect of block compositions of amphiphilic block copolymers on the physicochemical properties of polymeric micelles. Polymer. 2011;52(17):3783-3790.
34. Akimoto J, Nakayama M, Sakai K, Okano T. Thermally controlled intracellular uptake system of polymeric micelles possessing poly(n-isopropylacrylamide)-based outer coronas. Mol Pharm. 2010;7(4): 926-935.
35. Li W, Zhao H, Qian W, etal. Chemotherapy for gastric cancer by finely tailoring anti-Her2 anchored dual targeting immunomicelles. Biomaterials. 2012;33(21):5349-5362.
36. Bates FS, Fredrickson GH. Block copolymers-designer soft materials. Physics Today. 1999;52:32.
37. Guo Z, Zhang G, Qiu F, Zhang H, Yang Y, Shi AC. Discovering ordered phases of block copolymers: new results from a generic Fourier-space approach. Phys Rev Lett. 2008;101(2):028301.
38. Zetterlund PB, Kagawa Y, Okubo M. Controlled/living radical polymerization in dispersed systems. Chem Rev. 2008;108(9): 3747-3794.
39. Nakayama M, Okano T. Polymer terminal group effects on properties of thermoresponsive polymeric micelles with controlled outer-shell chain lengths. Biomacromolecules. 2005;6(4):2320-2327.
40. Zhu J, Tang A, Law LP, etal. Amphiphilic core-shell nanoparticles with poly(ethylenimine) shells as potential gene delivery carriers. Bioconjug Chem. 2005;16(1):139-146.
41. Fu Y, Kao WJ. Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems. Expert Opin Drug Deliv. 2010;7(4):429-444.
42. Yue Y, Jin F, Deng R, etal. Revisit complexation between DNA and polyethylenimine-Effect of uncomplexed chains free in the solution mixture on gene transfection. J Control Release. 2011;155(1):67-76.
43. Yang Z, Sahay G, Sriadibhatla S, Kabanov AV. Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA. Bioconjug Chem. 2008;19(10):1987-1994.
44. Akinc A, Thomas M, Klibanov AM, Langer R. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med. 2005;7(5):657-663.
45. Uchegbu IF. Pharmaceutical nanotechnology: polymeric vesicles for drug and gene delivery. Expert Opin Drug Deliv. 2006;3(5):629-640.
46. Bates FS, Fredrickson GH. Block copolymer thermodynamics: theory and experiment. Annu Rev Phys Chem. 1990;41:525-557.
47. Hadjichristidis N, Pispas S, Floudas G. Dilute solutions of block copolymers in selective solvents. Block Copolymers: Synthetic Strategies, Physical Properties and Applications. New York NY: Wiley; 2003:203-231.
48. Hadjichristidis N, Pispas S, Floudas G. Adsorption of block copolymers at solid-liquid interfaces. Block Copolymers: Synthetic Strategies, Physical Properties and Applications. New York NY: Wiley; 2003: 232-254.
49. Hadjichristidis N, Pispas S, Floudas G. Theory. Block Copolymers: Synthetic Strategies, Physical Properties and Applications. New York NY: Wiley; 2003:257-267.
50. Han L, Miyasaka K, Terasaki O, Che S. Evolution of packing parameters in the structural changes of silica mesoporous crystals: cage-type, 2D cylindrical, bicontinuous diamond and gyroid, and lamellar. J Am Chem Soc. 2011;133(30):11524-11533.
51. Ma L, Eisenberg A. Relationship between wall thickness and size in block copolymer vesicles. Langmuir. 2009;25(24):13730-13736.
52. Sonntag Y, Musgaard M, Olesen C, etal. Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes. Nat Commun. 2011;2:304.
53. Teraoka I. Dynamics of dilute polymer solutions. Polymer Solution: An Introduction to Physical Properties. New York, NY: Wiley; 2002: 167-276.