Efficient intracellular gene delivery using the formulation composed of poly (L-glutamic acid) grafted polyethylenimine and histone

Pharmaceutical Research

Volumn 28, Issue 4, 2011, Pages 812-826

  Deng, Jingjing ^a,b   Wen, Yuting ^a   Wang, Cuifeng ^a,b   Pan, Shirong ^a   Gu, Huaiyu ^c   Zeng, Xin ^a,b   Han, Lina ^a,b   Zhao, Yuefang ^a,b   Feng, Min ^a,b   Wu, Chuanbin ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b Research and Development Center of Pharmaceutics of Guangdong Province   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

chloroquine; gene delivery formulation; histone; poly (L glutamic acid); polyethylenimine; transfection efficiency

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CHLOROQUINE; GREEN FLUORESCENT PROTEIN; HISTONE; LIPOFECTAMINE; PLASMID DNA; POLYCATION; POLYETHYLENEIMINE; POLYGLUTAMIC ACID;

AMINOLYSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DNA HISTONE INTERACTION; DROSOPHILA MELANOGASTER; DRUG FORMULATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPE; GENE VECTOR; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO GENE TRANSFER; IN VIVO STUDY; MOLECULAR WEIGHT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ZETA POTENTIAL;

ANIMALS; CELL NUCLEUS; CELL SURVIVAL; CHLOROQUINE; DNA; DROSOPHILA MELANOGASTER; DRUG CARRIERS; ENDOSOMES; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HELA CELLS; HISTONES; HUMANS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; NUCLEAR LOCALIZATION SIGNALS; PARTICLE SIZE; PLASMIDS; POLYETHYLENEIMINE; POLYGLUTAMIC ACID; SPECTROMETRY, FLUORESCENCE; SURFACE PROPERTIES; TRANSFECTION;

EID: 79955612438     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0335-z     Document Type: Article

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