The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors

Biomaterials

Volumn 32, Issue 15, 2011, Pages 3832-3844

  Li, Wei ^a,b   Li, Jinfeng ^a   Gao, Jie ^a,b   Li, Bohua ^a,b,c   Xia, Yu ^a   Meng, Yanchun ^a   Yu, Yongsheng ^a   Chen, Huaiwen ^a   Dai, Jianxin ^a,b,c   Wang, Hao ^a,b,c   Guo, Yajun ^a,b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Engineering Research Center for Antibody Medicine   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Block copolymer; Drug delivery; Fine synthesis and characterization; Polymer micelle

Indexed keywords

ADRIAMYCIN; AGGREGATION NUMBERS; CANCER CELLS; CAPROLACTONE; CELLULAR UPTAKE; CONFOCAL LASER SCANNING MICROSCOPY; CORE SHELL STRUCTURE; CORE-SHELL; CRITICAL MICELLIZATION CONCENTRATION; DEGRADABLE POLYMERS; DIALYSIS METHOD; DIBLOCK COPOLYMER; DRUG RELEASE; FINE SYNTHESIS AND CHARACTERIZATION; FLUORESCENT MICROSCOPY; HIGH TEMPERATURE; HYDROPHOBIC BLOCKS; IN-VITRO; INTER-MICELLAR; INTRACELLULAR UPTAKE; LASER LIGHT SCATTERING; N ,N-DIMETHYLACRYLAMIDE; N-ISOPROPYLACRYLAMIDES; PH-RESPONSIVE; POLYMER MICELLE; POLYMERIC MICELLE; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER; SECOND VIRIAL COEFFICIENTS; TAXOTERE; TEM; THERMO SENSITIVE; TUMOR TISSUES; VOLUME PHASE TRANSITION;

ACRYLIC MONOMERS; AMIDES; BLOCK COPOLYMERS; CONFOCAL MICROSCOPY; COPOLYMERIZATION; DIALYSIS; DRUG DELIVERY; FLOW CYTOMETRY; FUNCTIONAL POLYMERS; LIGHT SCATTERING; MICELLES; PHASE TRANSITIONS; TUMORS;

PHARMACODYNAMICS;

DOCETAXEL; DOXORUBICIN; POLY(N ISOPROPYLACRYLAMIDE CO N,N DIMETHYLACRYLAMIDE B EPSILON CAPROLACTONE); POLY(N ISOPROPYLACRYLAMIDE CO N,N DIMETHYLACRYLAMIDE B LACITDE); POLYMER; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADABILITY; CANCER CELL; DRUG DELIVERY SYSTEM; DRUG RELEASE; HEAT SENSITIVITY; HUMAN; HUMAN CELL; MICELLE; PH MEASUREMENT; PRIORITY JOURNAL;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; HUMANS; HYDROGEN-ION CONCENTRATION; MICELLES; NEOPLASMS; POLYMERS; TEMPERATURE;

EID: 79952750426     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.01.075     Document Type: Article

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