Chemotherapy for gastric cancer by finely tailoring anti-Her2 anchored dual targeting immunomicelles

Biomaterials

Volumn 33, Issue 21, 2012, Pages 5349-5362

  Li, Wei ^a,b   Zhao, He ^a   Qian, Weizhu ^a,b   Li, Huafei ^a   Zhang, Li ^a   Ye, Zengwei ^a   Zhang, Ge ^a   Xia, Mao ^a   Li, Jinfeng ^a   Gao, Jie ^a,b   Li, Bohua ^a,b,c   Kou, Geng ^a,b,c   Dai, Jianxin ^a,b,c   Wang, Hao ^a,b,c   Guo, Yajun ^a,b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Engineering Research Center for Antibody Medicine   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Antibody; Block copolymer; Gastric tumor inhibition; Immunomicelles; Serum stability; Tumor accumulation

Indexed keywords

ACTIVE TARGETING; ANTIBODY FAB FRAGMENTS; CELLULAR UPTAKE; CHAIN DENSITY; CYTOTOXICITY ASSAYS; DOXORUBICIN; GASTRIC CANCER CELLS; GASTRIC CANCERS; GASTRIC TUMORS; HIGH STABILITY; IMMUNOMICELLES; IN-VIVO; INTRACELLULAR ACCUMULATION; LOADING CAPACITIES; NUDE MICE; OVER-EXPRESSION; SERUM STABILITY; STRUCTURAL DEFORMATION; THERMO SENSITIVE; TUMOR ACCUMULATION; TUMOR VOLUMES; VOLUME PHASE TRANSITION;

ACRYLIC MONOMERS; ANTIBODIES; BLOCK COPOLYMERS; BODY FLUIDS; DISEASES; LOADING; STABILITY; TUMORS;

CHEMOTHERAPY;

COPOLYMER; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; POLY(N ISOPROPYLACRYLAMIDE CO N,N DIMETHYLACRYLAMIDE)118; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL STRUCTURE; CELL TRANSPORT; CHEMICAL STRUCTURE; CYTOTOXICITY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; FAB FRAGMENT CONJUGATED IMMUNOMICELLE; HEAT SENSITIVITY; IC 50; IN VIVO STUDY; MICELLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; SYNTHESIS; TARGET CELL; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; DIALYSIS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN FAB FRAGMENTS; INTRACELLULAR SPACE; LACTIC ACID; MICE; MICE, NUDE; MICELLES; POLYGLYCOLIC ACID; RECEPTOR, ERBB-2; REPRODUCIBILITY OF RESULTS; SERUM; SOLVENTS; STOMACH NEOPLASMS; TEMPERATURE; TISSUE DISTRIBUTION;

MUS MUSCULUS;

EID: 84860916493     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.04.016     Document Type: Article

References (53)

1. Kwon G.S., Kataoka K. Block copolymer micelles as long circulating drug vehicles. Adv Drug Deliv Rev 1995, 16:295-309.
2. Croy S.R., Kwon G.S. Polymer micelle for drug delivery. Curr Pharm Des 2006, 12:4669-4684.
3. Akimoto J., Nakayama M., Sakik K., Okano T. Temperature-induced intracellular uptake of thermoresponsive polymeric micelles. Biomacromolecules 2009, 10:1331-1336.
4. Kakizawa K., Kataoka K. Block copolymer micelles for delivery of gene and related compounds. Adv Drug Deliv Rev 2002, 54:203-222.
5. Rapoport N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Prog Poly Sci 2007, 32:962-990.
6. Wang Y., Gao S.J., Wen H., Yoon H.S., Yang Y.Y. Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer. Nat Mater 2006, 5:791-796.
7. Xiong X.B., Lavasanifar A. Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin. ACS Nano 2011, 5:5202-5213.
8. Zhu Z., Sukhishvili S.A. Temperature-induced swelling and small molecule release with hydrogen-bonded multilayers of block copolymer micelles. ACS Nano 2009, 3:3595-3605.
9. Nasongkla N., Bey E., Ren J., Ai H., Khemtong C., Guthi J.S., et al. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery system. Nano Lett 2006, 6(11):2427-2430.
10. Opanasopit P., Yokoyama M., Watanabe M., Kawano K., Maitani Y., Okano T. Block copolymer design for camptothecin incorporation into polymeric micelles for passive tumor targeting. Pharm Res 2004, 21:2001-2008.
11. Kwon G., Suwa S., Yokoyama M., Okano T., Sakurai Y., Kataoka K. Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxde-aspartate) block copolymer-adriamycin conjugates. J Control Release 1994, 29:17-23.
12. Bae Y., Nishiyama N., Fukushim S., Koyama H., Yasuhiro M., Kataoka K. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled cubcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem 2005, 16:122-130.
13. Quina F.H., Alonso E.O., Farah J.P.S. Incorporation of nonionic solutes into aqueous micelles: a linear solvation frees energy relationship analysis. J Phys Chem 1995, 99:11708-11714.
14. Letchford K., Liggins R., Burt H. Solubilization of hydrophobic drugs by methoxy poly(ethyleneglycol)-block-polycaprolactone diblock copolymer micelles: theoretical and experimental data and correlations. J Pharm Sci 2008, 97:1179-1190.
15. Sun T.M., Du J.Z., Yan L.F., Mao H.Q., Wang J. Self-assembled biodegradable micellar nanoparticels of amphiphilic and cationic block copolymer for SiRNA delivery. Biomaterials 2008, 29:4348-4355.
16. Win K.Y., Feng S.S. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 2005, 15:2713-2722.
17. Soo P.L., Luo L., Maysinger D., Eisenberg A. Incorporation and release of hydrophobic probes in biocompatible polycaprolactone-blcok-poly(ethylene oxide) micelles: implications for drug delivery. Langmuir 2002, 18:9996-10004.
18. Li L., Guan Y., Liu H., Hao N., Liu T., Tang F., et al. Silica nanorattle doxorubicin-anchored mesenchymal stem cells for tumor-tropic therapy. ACS Nano 2011, 5:7462-7470.
19. Kano M.R., Bae Y., Iwata C., Morishita Y., Yashiro M., Miyazono K., et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling. Proc Natl Acad Sci U S A 2007, 104:3460-3465.
20. Torchilin V.P., Lukyanov A.N., Gao Z.G., Papahadjopoulos-Sternberg B. Immunomicelles: targeted harmaceutical carriers for poorly soluble drugs. Proc Natl Acad Sci U S A 2003, 100:6039-6044.
21. Sawant R.R., Sawant R.M., Torchilin V.P. Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity. Eur J Pharm Biopharm 2008, 70:51-57.
22. Tai W., Mahato R., Cheng K. The role of HER2 in cancer therapy and targeted drug delivery. J Control Release 2010, 146:264-275.
23. Geuna E., Milani A., Redana S., Rossi V., Valabrega G., Montemurro F., et al. Hitting multiple targets in HER2-positive breast cancer: proof of principle or therapeutic opportunity?. Expert Opin Pharmacother 2011, 12(4):549-565.
24. Smith B., Lyakhov I., Loomis K., Needle D., Baxa, Puri A., et al. Hyperthermia-triggered intracellular delivery of anticancer agent to HER2(+) cells by HER2-specific affibody (ZHER2-GS-Cys)-conjugated thermosensitive liposomes (HER2(+) affisomes). J Control Release 2011, 153(2):187-194.
25. Tanner M., Hollén M., Junttila T.T., Kapanen A.I., Tommola S., Soini Y., et al. Amplification of Her-2in gastric carcinoma: association with topoisomerase ||α gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol 2005, 16:273-278.
26. Brown J.M., Giaccia A.J. The unique physiology of solid tumors: opportunities (and Problems) for cancer therapy. Cancer Res 1998, 58:1408-1416.
27. Yahara T., Koga T., Yoshida S., Nakagawa S., Geguchi H., Shirouzu K. Relationship between microvessel density and thermographic hot area in breast cancer. Surg Today 2003, 33:243-248.
28. Trédan O., Galmarini C.M., Patel K., Tannock I.F. Drug resistance and the solid tumor microenviroment. J Natl Cancer Inst 2007, 99:1141-1154.
29. Nishiyama N., Bae Y., Miyata K., Fukushima S., Kataoka K. Smart polymeric micelles for gene and drug delivery. Drug Discov Today: Tech 2005, 2:21-26.
30. Nakayama M., Okano T., Miyazaki T., Kohori F., Sakai K., Yokoyama M. Molecular design of biodegradable polymeric micelles for temperature-responsive drug release. J Control Release 2006, 115:46-56.
31. Takae S., Miyata K., Oba M., Ishii T., Nishiyama N., Kataoka K., et al. PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J Am Chem Soc 2008, 130(18):6001-6009.
32. Li W., Li J.F., Gao J., Li B., Xia Y., Guo Y., et al. The fine-tuning thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors. Biomaterials 2011, 32(15):3832-3844.
33. Thang S.H., Chong Y.K., Mayadunne R.T.A., Moad G., Rizzardo E. A novel synthesis of functional dithioesters, dithiocarbamates, xanthates and trithiocarbonates. Tetrahedron Lett 1999, 40:2435-2438.
34. Valencia P.M., Basto P.A., Zhang L.F., Rhee M., Langer R., Karnik R., et al. Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. ACS Nano 2010, 4(3):1671-1679.
35. Gao J., kou G., Wang H., Chen H., Li B., Guo Y., et al. PE38KDEL-loaded anti-Her2 nanoparticles inhibit breast tumor progression with refuced toxicity and immunogenicity. Breast Cancer Res 2009, 115:29-41.
36. Oba M., Miyata K., Osada K., Christie R.J., Sanjoh M., Li W., et al. Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials 2011, 32:652-663.
37. Kabanov A.V., Nazarova I.R., Astafieva I.V., Bastrakova E.V., Alakhov V.Y., Kabanov V.A. Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions. Macromolecules 1995, 28:2303-2314.
38. Li W., Nakayama M., Akimoto J., Okano T. Effect of block compositions of amphiphilic block copolymers on the physicochemical properties of polymeric micelles. Polymer 2011, 52:3783-3790.
39. Nagarajan R. Molecular packing parameter and surfactant self-assembly: the neglected role of the surfactant tail. Langmuir 2002, 18:31-38.
40. Hadjichristidis N., Pispas S., Floudas G. Block copolymers, synthesis strategies, physical properties and applications 2003, John Wiley & Sons Inc, [Chapter 11-13].
41. Chan J.M., Zhang L., Yuet K.P., Liao G., Rhee J.W., Langer R., et al. PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery. Biomaterials 2009, 30:1627-1634.
42. Reichardt C. Solvents and solvent effects in organic chemistry 2004, John Wiley & Sons Inc, pp. 418-442. 3rd ed.
43. Wu C., Li W., Zhu X.X. Viscoelastic effect on the formation of mesoglobular phase in dilute solutions. Macromolecules 2004, 37(13):4989-4992.
44. Cheng H., Wu C., Winnik M.A. Kinetics of reversible aggregation of soft polymeric particles in dilute dispersion. Macromolecules 2004, 37(13):5127-5129.
45. Schild H.G. Poly(N-isopropylacrylamide): experiments, theory and application. Prog Poly Sci 1992, 17:163-249.
46. Hu H., Wu C. Clustering induced collapse of a polymer brush. Phys Rev Lett 1999, 83(20):4105.
47. Khougaz K., Zhong X.F., Eisenberg A. Aggregation and critical micelle concentrations of polystyrene-b-poly(sodium acrylate) and polystyrene-b-poly(acrylic acid) micelles in organic media. Macromolecules 1996, 29:3937-3949.
48. Wohlfart S., Khalansky A.S., Gelperina S., Maksimenko O., Bernreuther C., Glatzel M., et al. Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers. PloS One 2011, 6. e19121.
49. 2O/DMF solvent mixtures. Macromolecules 1997, 30:7143-7150.
50. Dunn S.E., Brindley A., Davis S.S., Davies M.C., Illum L. Polystyrene-poly(ethylene glycol) (PS-PEG2000) particles as model systems for site specific drug delivery. 2. the effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution. Pharm Res 1994, 11:1016-1022.
51. Israelachvili J., Wennerström H. Role of hydration and water structure in biological and colloid interactions. Nature 1996, 379:219-225.
52. Poon Z., Chang D., Zhao X., Hammond P.T. Layer-by Layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia. ACS Nano 2011, 5:4284-4292.
53. Hapca A.C., Buchegger F., Lange N., Bossy L., Gurny B., Delie F. Benefit of anti-Her2-coated paclitaxil-loaded immno-nanoparticles in the treatment of disseminated ovarian cancer: therapeutic efficiency and biodistribution in mice. J Control Release 2010, 144:324-331.