Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives

Journal of Medicinal Chemistry

Volumn 39, Issue 12, 1996, Pages 2302-2312

  Barth, Martine M ^a   Binet, Jean L ^a   Thomas, Didier M ^a   De Fornel, Daniel C ^a   Samreth, Soth ^a   Schuber, Francis J ^b   Renaut, Patrice P ^a  

^a Laboratoires Fournier SA   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DECAHYDRO 5,8A DIMETHYL 2 (1,5,9 TRIMETHYLDECYL) 6 ISOQUINOLINOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOQUINOLINE DERIVATIVE; LANOSTEROL SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; DRUG MECHANISM; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; DRUG DESIGN; ENZYME INHIBITORS; INTRAMOLECULAR TRANSFERASES; ISOMERASES; ISOQUINOLINES; KINETICS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PROTEIN BINDING; RATS; SQUALENE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029998404     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9504621     Document Type: Article

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